Terbium-doped gadolinium oxide nanoparticles prepared by laser ablation in liquid for use as a fluorescence and magnetic resonance imaging dual-modal contrast agent

Abstract

Dual-modal lanthanide-doped gadolinium nanoparticles (NPs), which exhibit an excellent magnetic resonance imaging (MRI) spatial resolution and high fluorescence imaging (FI) sensitivity, have attracted tremendous attention in biotechnology and nanomedicine applications. In this paper, terbium (Tb) ion doped gadolinium oxide (Gd2O3:Tb) NPs with varied Tb concentrations were synthesized by a laser ablation in liquid (LAL) method. The characterization of the structure, morphology, and composition shows that these NPs are spherical with excellent crystallinity. The effects of Tb ion concentration on the visible green fluorescence and longitudinal relaxivity were investigated, indicating that the fluorescence properties were significantly influenced by the Tb ion concentration, but all samples were still efficient T1-weighted contrast agents. Furthermore, the optimum Tb doping concentration was determined to be 1%. The cell viability, cellular fluorescence imaging and in vivo MRI of this dual-modal nano-probe were studied, with the results revealing that the Gd2O3:Tb NPs did not have a significant cytotoxic effect, making them good candidates for use as a dual-modal contrast agent for MRI and fluorescence imaging.

Magnetic and fluorescent Gd₂O₃:Yb³⁺/Ln³⁺ nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy

“…32 Our recent work has focused on the synthesis and development of ultra-small (sub-10 nm) lanthanide-doped Gd 2 O 3 nanoparticles for MR/fluorescence dual-modal imaging. [33][34][35][36] However, to the best of our knowledge, the ability of lanthanide-doped Gd 2 O 3 UCNs for theranostics application, which combines the diagnosis and treatment of cancer, has not previously been reported. In this contribution, the aim was to synthesis magnetic and fluorescent lanthanide-doped Gd 2 O 3 UCNs and simultaneously achieve MR/UCL dual-modal imaging and PDT.…”

Process Chain for the Fabrication of Nanoparticle Polymer Composites by Laser Ablation Synthesis

“…This coexistence of properties can be used for imaging techniques such as multimodal SERS-MRI-CT [62]. It is also possible to combine magnetic resonance and fluorescence properties for dual-modal imaging agents [79,80]. For this purpose, Gd 2 O 3 , the magnetic resonance imaging contrast agent, can be doped with Eu 3+ [79] or Tb 3+ [80] as a fluorescence-emitting center.…”

“…It is also possible to combine magnetic resonance and fluorescence properties for dual-modal imaging agents [79,80]. For this purpose, Gd 2 O 3 , the magnetic resonance imaging contrast agent, can be doped with Eu 3+ [79] or Tb 3+ [80] as a fluorescence-emitting center. Doping is easily carried out by mixing both oxide powders, their milling, target pressing, and sintering [79].…”

Silica-Coated Europium-Doped Gadolinium Oxide Nanorods for Dual-Modal Imaging of Cancer Cells

“…The optical properties of rare earth dopant ions combine with the magnetic property of the Gd 2 O 3 nanoparticles to produce dual modal images. 5 A single nanoparticle can be used to detect cancer cells with high spatial resolution and very high sensitivity. Therefore, rare earthdoped gadolinium oxide nanoparticles serve as a potential candidate for dual modal imaging.…”

“…The sensitivity of optical imaging is about 10 À12 moles of label detected, whereas the sensitivity of MRI ranges from 10 À9 to 10 À6 moles of label detected. 4,5 MRI is a noninvasive three-dimensional imaging of soft tissues, especially cancer cells. The advantage of using MRI is its high spatial resolution.…”