Terbium-Based Coordination Polymer Nanoparticles for Detection of Ciprofloxacin in Tablets and Biological Fluids

Abstract

The metal-organic coordination polymers with tunable structures and properties have been rapidly emerging as very important functional materials. In this work, we prepared terbium (Tb(3+))-based coordination polymer nanoparticles (CPNPs) by employing adenine (Ad) as bridging ligands. The CPNPs was further used as a receptor reagent for ciprofloxacin (CF) detection in aqueous solution. Addition of CF induces a typical emission of Tb(3+) due to the formation of Ad/Tb-CF complex and the sensitization of CF. The fluorescent intensity of Tb(3+) was enhanced linearly with increasing the CF concentration from 60 nM to 14 μM. The detection limit for CF in aqueous solution is 60 nM. The Ad/Tb CPNPs was successfully applied to detect CF in tablet and urine samples and showed a satisfactory result. Compared with other methods, the proposed method is advantageous because that it provides a very simple strategy for CF detection, which does not require complicated sample pretreatment processes or special reaction media. The proposed strategy could be contributed to expand the potential applications of lanthanide coordination polymers in biological and environmental fields.

Detection of Ciprofloxacin in Urine through Sensitized Lanthanide Luminescence

“…Nevertheless, only a few Ln 3+ -based fluorescent methods for Cipro detection are reported up to date, and those are often performed in conjunction with sample separating techniques [13,21,23,24]. There are two reports on the terbium-sensitized luminescence detection of ciprofloxacin or quinolone drugs, in which such sample extraction or separation procedures are not performed [25,26]. One of the methods used a mixture of TbCl 3 and a surfactant (SDBS: sodium dodecylbenzene sulfonate) that enhanced terbium luminescence most effectively in its critical micelle concentration [25].…”

“…A background signal, that is, the Tb(III) emission, in the absence of a quinolone (norfloxacin) drug is also observed. The other method used a polymeric nanoparticle system generated from Tb(NO 3 ) 3 ·6H 2 O and adenine to detect Cipro in tablet and urine samples without complicated sample pretreatment processes, but the luminescence measurement was performed in the time-gated mode to avoid the autofluorescence/background signals from the samples [26]. For time-gated luminescence measurement a special fluorimeter that uses a nitrogen laser source is needed.…”

Supramolecular self-assembly of nucleotide–metal coordination complexes: From simple molecules to nanomaterials

“…29). CNPs formed from adenine (Ad) and Tb 3+ were used as a receptor reagent for ciprofloxacin (CF) detection in aqueous solution based on the formation of the Ad/Tb-CF complex and the sensitization of CF[228]. After introducing dipicolinic acid (DPA) as an auxiliary linking molecule, an Ad-Tb 3+ -DPA coordination polymer NP was obtained, which can serve as a form of Hg 2+ nanosensor, with excellent selectivity and ultrahigh sensitivity up to the 0.2 nM detection limit.…”

Surfactant-mediated morphology and fluorescent properties of amino acids-based lanthanide coordination polymers

“…1a, the Phe/Tb CPs are spindle-like particles with an average length of 27.7 mm and average thickness of 17.58 mm. [18][19][20] The chemical compositions of these as-prepared particles were determined using energy dispersive spectroscopy (EDS). S2 †).…”