Terbinafine Induced Liver Injury: A Case Report

Imidazolium salts with antifungal potential against multidrug-resistant dermatophytes

“…The most effective and commercially available antifungals are mostly expensive and cause side effects, discouraging the patients to fully perform prolonged therapeutic treatments (Choudhary et al . ). Withal, the dermatophytic fungi are associated with an even more serious problem, which is their frequent multidrug‐resistance to conventional antifungal treatments.…”

“…The treatment of dermatophytoses is carried out, generally, with the use of topical and/or systemic antifungal agents associated or not with keratolytic substances (Lakshmipathy and Kannabiran 2010;Bikowski 2014). The most effective and commercially available antifungals are mostly expensive and cause side effects, discouraging the patients to fully perform prolonged therapeutic treatments (Choudhary et al 2014). Withal, the dermatophytic fungi are associated with an even more serious problem, which is their frequent multidrug-resistance to conventional antifungal treatments.…”

“…Withal, the dermatophytic fungi are associated with an even more serious problem, which is their frequent multidrug-resistance to conventional antifungal treatments. This causes a large variation in susceptibility among species, decreasing the favourable response necessary for a progressive improvement and subsequent cure (Mukherjee et al 2003;Choudhary et al 2014).…”

Concurrent terbinafine-induced acute generalised exanthematous pustulosis and hepatitis

“…A previously reported case showed a skin rash on sun-exposed areas on the fifth day of treatment with terbinafine and was diagnosed as photosensitisation induced by the treatment 9. Terbinafine has also been related with drug induced hepatitis 10 11. A concurrent diagnosis of AGEP and hepatitis is reported in our patient secondary to terbinafine.…”

In Vitro Triple Combination of Antifungal Drugs against Clinical Scopulariopsis and Microascus Species

“…However, they may also induce liver injury. TRB may cause hepatotoxicity, with an incidence of 0.5 to 3/100,000 exposed, while CAS may cause an increase in alanine aminotransferase (ALT), aspartate transaminase (AST), and alkaline phosphatase (AKP) levels (32)(33)(34). Patient liver function should be regularly assessed during treatment.…”