Teratomas of the cranial vault: a systematic analysis of clinical outcomes stratified by histopathological subtypes

Lagman, Carlito; Bui, Timothy T.; Voth, Brittany; Chung, Lawrance K.; Seo, David J.; Duong, Courtney; Libowitz, Mark R.; Walker, Nicole; Nagasawa, Daniel T.; Yang, Isaac

doi:10.1007/s00701-016-3064-1

Cited by 5 publications

(5 citation statements)

References 85 publications

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“…Radiation therapy remains an important accepted treatment for intracranial teratoma ( 8 ). Mature teratoma is considered to have limited benefit from radiotherapy, but relapsed mature teratoma is sensitive to radiotherapy ( 9 ). However, no consensus has been reached on the dose and volume of radiotherapy ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

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Genomic characterization of intracranial teratomas using whole genome sequencing

et al. 2022

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BackgroundIntracranial teratoma is a rare neoplasm of the central nervous system, often classified into mature and immature types and occurs mainly in children and adolescents. To date, there has been no comprehensive genomic characterization analysis of teratoma due to its rarity of the cases.MethodsForty-six patients with intracranial teratomas were collected and 22 of them underwent whole-exome sequencing, including 8 mature teratomas and 14 immature teratomas. A comprehensive analysis was performed to analyze somatic mutations, copy number variants (CNVs), mutational signatures, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway in our cohort.ResultsThe most common somatic mutated gene in intracranial teratomas was CARD11 (18%) and IRS1 (18%), followed by PSMD11, RELN, RRAS2, SMC1A, SYNE1 and ZFHX3, with mutation rates of 14% for the latter six genes. Copy number variation was dominated by amplification, among which ARAF (50%), ATP2B3 (41%), GATA1 (41%), ATP6AP1 (36%), CCND2 (36%) and ZMYM3 (36%) were the most frequently amplified genes. Copy number deletion of SETDB2 and IL2 only appeared in immature teratoma (43% and 36%, respectively), but not in mature teratoma (p = 0.051 and 0.115, respectively). Prognostic analysis showed that TP53 mutations might be associated with poor prognosis of intracranial teratomas patients.ConclusionsOur study revealed the genetic characteristics of intracranial teratoma which might be valuable for guiding future targeted therapies.

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Section: Introductionmentioning

confidence: 99%

“…However, no consensus has been reached on the dose and volume of radiotherapy ( 10 , 11 ). Moreover, platinum-based chemotherapy has different efficacy for various subtypes ( 9 ). Therapeutic strategy aimed to improve quality of life and prolong progression-free and overall survival are ongoing.…”

Section: Introductionmentioning

confidence: 99%

Genomic characterization of intracranial teratomas using whole genome sequencing

et al. 2022

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“…Germ cell tumors (GCTs) of the central nervous system are relatively rare, comprising 0.5 to 3% of all intracranial tumors. 1 Germ cell tumors are divided into the following classes: germinomas, nongerminomatous (teratoma, embryonic carcinoma, endodermal sinus tumor, and choriocarcinoma), and mixed GCT. Teratomas are a subtype of GCTs characterized by the presence of somatic tissues derived from two or three germ layers (the ectoderm, the endoderm, and the mesoderm), which commonly affect the child population 2 and, when they affect adults, they are commonly derived from gonadal tissues.…”

Section: Introductionmentioning

confidence: 99%

“…2 5 6 7 These tumors tend to appear in the midline structures of the brain, mainly in the pineal and suprasellar regions, possibly due to the great potential of these areas for displacement of progenitor germ cells. 1 8…”

Section: Introductionmentioning

confidence: 99%

“…2,[5][6][7] These tumors tend to appear in the midline structures of the brain, mainly in the pineal and suprasellar regions, possibly due to the great potential of these areas for displacement of progenitor germ cells. 1,8 Reports of the image pattern of teratomas are scarce in the literature. Most of the knowledge we have are from case reports or from a few small series.…”

Section: Introductionmentioning

confidence: 99%

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Intracranial Teratoma in Young Adult Female: Case Report

Marques

Haag

Buffara

et al. 2022

Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery

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Intracranial teratoma corresponds to a type of germ cell tumor (GCT) of the central nervous system which is characterized by the presence of tissues derived from the germinal layers, which may have hair and adipose tissue inside, for example. The literature on the subject is scarce, and the T2 magnetic resonance imaging (MRI) pattern commonly found is that of a heterogeneously hyperintense mass and, after contrast, teratoma presents heterogeneous enhancement. Therefore, the present case report aims to present atypical results of a GCT in a young adult woman. Data analysis and compilation were performed from medical records, as well as the neuroimaging study. Thus, the present case report demonstrates neuroimaging findings with homogeneous postcontrast enhancement in an adult patient, with an unusual age profile when compared with most of the studies published so far. This demonstrates that it is possible to have atypical neuroimaging findings for mature teratomas and that they can behave in a less aggressive way, not requiring adjuvant postoperative therapies.

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