Teratomas in central nervous system: A clinico-morphological study with review of literature

Agrawal, Manindra; Uppin, Megha S; Patibandla, Mohana Rao; Bhattacharjee, Suchanda; Panigrahi, Manas; Saradhi, Vijay; Rani, Jyotsna; Purohit, A K; Challa, Sundaram

doi:10.4103/0028-3886.73740

Cited by 36 publications

(40 citation statements)

References 15 publications

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“…Teratomas in the central nervous system are typically located in midline structures, supporting the theory that they originate from pluripotent cell rests at the sites of early neural tube closure [9,10,12,13,14]. Well-known associations of teratomas in the spinal cord with dysraphic congenital spinal malformations such as spina bifida, syrinx, dermal sinus, split cord, meningomyelocele and lipomeningomyelocele suggest an embryogenetic error related to dysfunction of genetic and cellular inductive mechanisms [12,13,14].…”

Section: Discussionmentioning

confidence: 99%

“…Common sites of predilection include the pineal, suprasellar and hypothalamic regions. It is classified into mature, immature and malignant types based on histology [9,10]. Amongst the unusual pathologies reported to have occurred concomitantly with a teratoma are an interparietal encephalocele [11] and spinal dysraphism [12,13,14].…”

Section: Discussionmentioning

confidence: 99%

“…Another rare dysembryonic lesion, the teratoma, represents 0.5% of all intracranial tumors [9]. Common sites of predilection include the pineal, suprasellar and hypothalamic regions.…”

Section: Discussionmentioning

confidence: 99%

“…There have been anecdotal reports of its association with other congenital lesions like Rathke’s cleft cyst [4] and arachnoid cysts in the suprasellar [5] and temporo-sylvian [6,7,8] regions. Our report discusses a hitherto undescribed synchronous association of this lesion with a teratoma, another congenital lesion with a predilection for the suprasellar region [9,10]. Such an occurrence helps in clarifying its dysontogenetic pathogenesis [4,5,6,7,8].…”

Section: Introductionmentioning

confidence: 99%

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Synchronous Occurrence of a Hemorrhagic Hypothalamic Hamartoma and a Suprasellar Teratoma

Kiran

Ghosal²,

Thakar³

et al. 2011

Pediatr Neurosurg

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Hypothalamic hamartomas have been reported to coexist with lesions like Rathke’s cleft cyst and arachnoid cysts in the suprasellar or temporo-sylvian regions. This is the first report in indexed literature describing its association with a suprasellar teratoma. A 7-year-old girl presented with long-standing precocious puberty and generalized tonic-clonic seizures and recent-onset raised intracranial pressure. MRI done prior to the onset of symptomatic raised intracranial pressure revealed 2 distinct lesions in the suprasellar region. One was a midline, pedunculated lesion arising from the hypothalamus, with evidence of an old bleed within it. A separate lesion, with a wide base near the tuberculum sellae and a posteriorly directed conical tip, was noted in an adjacent sagittal cut. CT scan done at the time of admission demonstrated a re-bleed in the suprasellar region with blood in the lateral and third ventricles and gross hydrocephalus. The child was taken up for a ventriculoperitoneal shunt followed by complete excision of the lesions. Histopathologic examination confirmed the pedunculated lesion to be a hypothalamic hamartoma with evidence of hemorrhage, and the other to be a mature teratoma. Postoperative MRI confirmed complete excision of both the lesions. The child reported regression of precocious puberty and remained seizure-free until the last follow-up 6 months after surgery. A hypothesis based on a dysontogenetic mechanism is discussed to explain the unusual occurrence of the dual, seemingly unrelated pathologies. Hemorrhage into the hamartoma was an added oddity in this case.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Another rare dysembryonic lesion, the teratoma, represents 0.5% of all intracranial tumors [9]. Common sites of predilection include the pineal, suprasellar and hypothalamic regions.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synchronous Occurrence of a Hemorrhagic Hypothalamic Hamartoma and a Suprasellar Teratoma

Kiran

Ghosal²,

Thakar³

et al. 2011

Pediatr Neurosurg

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show abstract

“…Primary central nervous system (CNS) teratomas are rare, and can manifest as an intracranial and/or spinal lesions (Smoker et al, 1986; Agrawal et al, 2010). Primary CNS teratomas, similar to other germ cell tumors, usually arise in midline structures (Schild et al, 1996; Kumar et al, 2005).…”

Section: Introductionmentioning

confidence: 99%