Teratogenic Effect of Cadmium and its Inhibition by Zinc

Ferm, Vergil H.; Carpenter, Stanley J.

doi:10.1038/2161123a0

Cited by 134 publications

(26 citation statements)

References 6 publications

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“…When selenium salts were simultaneously injected, no placental effects could be produced. A teratogenic effect of cadmium has been demonstrated in the hamster (173). This effect was inhibited by zinc.…”

Section: Toxic Effects In Man and Animalsmentioning

confidence: 97%

Environmental Impact of Cadmium: A Review by the Panel on Hazardous Trace Substances

Fleischer¹,

Sarofim²,

Fassett³

et al. 1974

Environmental Health Perspectives

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Section: Toxic Effects In Man and Animalsmentioning

confidence: 97%

Environmental Impact of Cadmium: A Review by the Panel on Hazardous Trace Substances

Fleischer¹,

Sarofim²,

Fassett³

et al. 1974

Environmental Health Perspectives

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“…Cadmium causes embryo/fetal lethality and a wide range of malformations that vary in scope and severity according to species, route, dose, and gestational time of administration (Barr, 1973;Ferm and Carpenter, 1967;Ishizu et al, 1973). Furthermore, sensitivity to cadmium-induced birth defects varies dramatically among inbred strains of mice (Layton and Layton, 1979;Pierro and Haines, 1978;Wolkowski, 1974).…”

Section: Introductionmentioning

confidence: 98%

Identification of a Murine Locus Conveying Susceptibility to Cadmium-Induced Forelimb Malformations

et al. 2000

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“…In the golden hamster during early gestation (8th to 9th day), cadmium causes résorptions and embryonic structural defects, the character of which is dependent on the time of administration (Ferm & Carpenter, 1967;Ferm, 1971; Gale & Ferm, 1973). These authors thought that cadmium was an embryonic "site-specific teratogen" due to its interference with specific enzy¬ matic reactions.…”

Section: Introductionmentioning

confidence: 99%

Possible Mechanisms of Cadmium Fetotoxicity in Golden Hamsters and Mice: Uptake by the Embryo, Placenta and Ovary

Dencker¹

1975

Reproduction

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Summary. Pregnant golden hamsters and mice of different gestational ages were injected intravenously with 109CdCl2. The whole animal or the uterus and embryos were submitted to autoradiography. Cadmium administered on the 8th day accumulated in the primitive gut of the embryos. No cadmium was detected in the embryos after administration on or after the 9th day (hamster) and 11th day (mouse). This finding can be explained by the ability of cadmium to pass from the yolk-sac cavity into the primitive gut (where it is absorbed) before the closure of the vitelline duct but not later. This uptake by the embryo might explain the severe malformations produced by cadmium given on the 8th day as compared with the 9th day in the hamster. Cadmium is also heavily accumulated in the decidua (mainly the antimesometrial part), the yolk sac, the ectoplacental cone, and later in the chorioallantoic placenta\p=m-\possiblydisturbing the maternal-embryonic relationship and fetal nutrition. A high accumulation in the CL and the follicles and in the pituitary may also disturb reproductive function.

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Teratogenic Effect of Cadmium and its Inhibition by Zinc

Cited by 134 publications

References 6 publications

Environmental Impact of Cadmium: A Review by the Panel on Hazardous Trace Substances

Environmental Impact of Cadmium: A Review by the Panel on Hazardous Trace Substances

Identification of a Murine Locus Conveying Susceptibility to Cadmium-Induced Forelimb Malformations

Possible Mechanisms of Cadmium Fetotoxicity in Golden Hamsters and Mice: Uptake by the Embryo, Placenta and Ovary

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