Teratogenic and embryotoxic effects of orally administered cypermethrin in pregnant albino rats

Emeka, Promise Madu

doi:10.5897/jtehs2015.0336

Cited by 16 publications

(6 citation statements)

References 27 publications

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“…The result of the present study showed a decrease in the litter weight of the F1 male generation of the CC group throughout the lactation period, relative to that of the other groups. This result agreed with previous ndings following CP 30 and CY 43 exposure. Perera et al 13 reported an association between CP exposure and low-birthweight among the African-American population, while a similar relationship has been between umbilical cord plasma CP levels and foetal birth weight.…”

Section: Discussionsupporting

confidence: 94%

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Melatonin Ameliorates Developmental Landmarks Induced by Gestational and Lactational Coexposure to Chlorpyriphos and Cypermethrin in F1 Male Rats

Shittu

Ambali

Ayo

et al. 2021

Preprint

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The ameliorative potentials of melatonin (ML) on developmental changes evoked by gestational and lactational co-exposure to chlorpyriphos (CP) and cypermethrin (CY) was investigated in male Wistar rats. Pregnant dams were divided at random into 6 groups of 10 animals each and treated orally by gavage from gestation day 1 to postnatal day 21 with the following regimens: The DW, SO and ML groups were administered distilled water (2 ml/kg), soya oil (2 ml/kg) and melatonin (0.5 mg/kg), respectively; CC group was co-administered CP (1.9 mg/kg) and CY (7.5 mg/kg); MC group was pretreated with ML (0.5 mg/kg) and followed by co-administration of CP and CY while the CM group was administered CP and CY and then treated with ML. We evaluated the developmental parameters on the F1 generation male rats at different postnatal intervals following parturition. Alterations in litter size and weight, number of live/dead pups, anogenital distance, crown-rump length, time of eye and ear openings, and testicular descent induced by gestational and lactational exposure to CP and CY in F1 male rats were mitigated by pre- and post-administration of ML. These curative and prophylactic potentials of ML may be partly attributed to its widely known antioxidant property.

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Section: Discussionsupporting

confidence: 94%

“…Cypermethrin has been found to induce DNA damage 40 , chromosomal aberrations 41 and steroid hormone disruptions 42 . Indeed, Madu 43 demonstrated a decrease in the number of live-born fetuses following CY exposure. Similarly, CP has also been shown to cause genotoxic effects through DNA damage and cell apoptosis 40,44 .…”

Section: Discussionmentioning

confidence: 99%

Melatonin Ameliorates Developmental Landmarks Induced by Gestational and Lactational Coexposure to Chlorpyriphos and Cypermethrin in F1 Male Rats

Shittu

Ambali

Ayo

et al. 2021

Preprint

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“…Teratogenic development of chick embryo upon exposure of the mother to chlorantraniliprole, chlorpyrifos, cypermethrin, endosulfan, malathion and spinosad was also reported [63][64][65][66][67] . Moreover, increased fetal resorption and reduced number of live fetuses, along with skeletal abnormalities, were reported as signs of teratogenicity for fetuses of pregnant rats exposed on gestation day 6 through day 15 to chlorpyrifos 68 , cypermethrin 69,70 , dimethoate 69,71 , endosulfan 72 , emamectin benzoate 73 , fipronil 74 , and organophosphorus insecticides 75 .…”

Section: Discussionmentioning

confidence: 99%

Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses

Basal

Ahmed

Mahmoud

et al. 2020

Sci Rep

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Insecticides and other agrochemicals have become indispensable components of the agricultural system to ensure a notable increase in crop yield and food production. As a natural consequence, chemical residues result in significantly increased contamination of both terrestrial and aquatic ecosystems. The present study evaluated the teratogenic, genotoxic, and oxidative stress effects of residual-level lufenuron exposure on pregnant rats during the organogenesis gestational period of both mother and fetus. The tested dams were divided into three groups; control (untreated), low-dose group (orally administered with 0.4 mg/kg lufenuron) and high-dose group (orally administered with 0.8 mg/kg lufenuron). The dams of the two treatment groups showed teratogenic abnormalities represented by the asymmetrical distribution of fetuses in both uterine horns, accompanied by observed resorption sites and intensive bleeding in the uterine horns, whereas their fetuses suffered from growth retardation, morphologic malformations, and skeletal deformations. Histologic examination of the liver and kidney tissues obtained from mothers and fetuses after lufenuron exposure revealed multiple histopathologic changes. DNA fragmentation and cell cycle perturbation were also detected in the liver cells of lufenuron-treated pregnant dams and their fetuses through comet assay and flow cytometry, respectively. Moreover, lufenuron-induced oxidative stress in the liver of mothers and fetuses was confirmed by the increased malondialdehyde levels and decreased levels of enzymatic antioxidants (glutathione peroxidase and superoxide dismutase). Taken together, it can be concluded that lufenuron has a great potential in exerting teratogenic, genotoxic, and oxidative stresses on pregnant rats and their fetuses upon chronic exposure to residual levels during the organogenesis gestational period. The obtained results in the present study imply that women and their fetuses may have the same risk.

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“…Cy induces macromolecules damage (Hocine et al, 2016). Emeka (2015) reported a lower number of live-born foetuses resulting from Cy vulnerability. Likewise, Ch damages nucleic acid and cell apoptosis (Hocine et al, 2016;Vardavas et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Developmental deficits in male rat pups caused by maternal and dietary administration of chlorpyriphos and cypermethrin: Melatonin’s mitigating effect

et al. 2023

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The ability of melatonin to reduce growth inadequacy induced by parental and nutritional combination administration to chlorpyriphos (Ch) and cypermethrin (Cy) was examined in male albino rats. Oral alimentation was given to gravid dams divided into six groups ( n = 10; age: 12 weeks) from the first day of pregnancy to the 21st postnatal day. Distilled water (DW), Soya oil (SYO), and melatonin (MeL) groups were exposed to 2 mL/kg, 2 mL/kg, and 0.5 mg/kg, respectively; the Ch+Cy group was co-exposed to Ch (1.9 mg/kg of LD50) and Cy (7.5 mg/kg of LD50); the MChCy group was preconditioned with MeL (0.5 mg/kg), followed by co-exposure to Ch and Cy; and the ChCyM group was exposed to Ch and Cy and post treated with MeL. Male offspring rats were tested for ontogeny criteria at various points after accouchement. MeL pre- and post-administration reduced the variation in litter size and weight, number of live/dead pups, anogenital distance , crown-rump length, the timing of eye and ear openings, and testicular descent caused by fetal and nutritional co-administration to Ch+Cy in offspring male albino rats. MeL demonstrated preventive promise as a result of its apparent antioxidative capability.

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Teratogenic and embryotoxic effects of orally administered cypermethrin in pregnant albino rats

Cited by 16 publications

References 27 publications

Melatonin Ameliorates Developmental Landmarks Induced by Gestational and Lactational Coexposure to Chlorpyriphos and Cypermethrin in F1 Male Rats

Melatonin Ameliorates Developmental Landmarks Induced by Gestational and Lactational Coexposure to Chlorpyriphos and Cypermethrin in F1 Male Rats

Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses

Developmental deficits in male rat pups caused by maternal and dietary administration of chlorpyriphos and cypermethrin: Melatonin’s mitigating effect

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