Teratogenic and Carcinogenic Effects in the Offspring after Single Injection of Ethylnitrosourea to Pregnant Rats

Druckrey, H.; Ivanković, S.; Preußmann, R.

doi:10.1038/2101378a0

Cited by 251 publications

(56 citation statements)

References 4 publications

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“…A system which allows such an approach is the induction of rat brain tumours by ethylnitrosourea (ENU) which, when administered to pregnant rats after the 12th day of gestation, results in nearly all the offspring developing tumours of the nervous system. A large proportion of these (-60%) are macro-and micro-gliomas of the brain (Druckrey, Ivankovic and Preussmann, 1966;Wechsler, et al, 1969).…”

mentioning

confidence: 99%

Fibrinolytic Activity of Cultured Cells Derived During Ethylnitrosourea-induced Carcinogenesis of Rat Brain

Hince¹,

Roscoe²

1978

Br J Cancer

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Summary.-Using a fibrin-agarose-overlay technique, high levels of plasminogendependent fibrinolytic activity have been demonstrated in cell lines derived from an ethylnitrosourea-induced glioma of the rat brain. Cell lines derived from normal adult rat brain showed only low levels of activity. The degree of lysis produced by a cell line was dependent on the average number of cells per colony, and a different pattern of response was observed for tumour and normal cell lines. A good positive correlation existed between the level of fibrinolytic activity, growth in agar and tumourigenicity of a cell line. Fibrinolytic activity was associated with cell lines derived at various times in the latent period, before the appearance of a visible tumour. Many cell lines derived from rat brains at 57-60 (E7), 90-91 (E8) and 111-112 (E6) days after transplacental exposure to ethylnitrosourea showed fibrinolytic activity, and in the latter group the close association with growth in agar and tumourigenicity was also demonstrated. Results from cell lines derived in the E7 and E8 experiments indicated that the possession of fibrinolytic activity preceded the ability of cells to form colonies in agar.

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mentioning

confidence: 99%

Fibrinolytic Activity of Cultured Cells Derived During Ethylnitrosourea-induced Carcinogenesis of Rat Brain

Hince¹,

Roscoe²

1978

Br J Cancer

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“…It is worth mentioning that the colon-specific carcinogen dimethylhyrdrazine (DMH) along with AOM has been useful in developing our current understanding of the molecular mechanisms underlying sporadic colorectal carcinogenesis (Druckrey et al, 1966). To its advantage the carcinogen-induced mouse model develops tumor which show much similarities to the pathophysiology of the human CRC (Kaiser et al, 2007;Uronis et al, 2007).…”

Section: Carcinogen-induced Modelsmentioning

confidence: 99%

Animal Models of Colorectal Cancer in Chemoprevention and Therapeutics Development

Suman¹,

Fornace²,

Datta³

2012

Colorectal Cancer - From Prevention to Patient Care

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“…ENU was then injected intraperitoneally (i.p) to newborn rats (3-5 days old) with an acute dose of 80 mg/kg bodyweight. [12][13][14] Administration of Biological Response Modifiers (BRMs). Specific BRMs.…”

Section: Induction Of Brain Tumor With Ethylnitrosourea (Enu)mentioning

confidence: 99%

Differential regulation of the protein tyrosine kinase activity followingiInterleukin-2 (IL-2), Interferron gamma (IFN?) and SRBC administration in brain tumor induced conditions: SRBC acting as a dual potentiator in regulating the cytokine profile

Bhattacharjee

Sarkar²,

Dutta³

et al. 2004

Cancer Biology & Therapy

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Protein tyrosine kinases (PTKs) act as an important class of signal transducer in cytokine mediated signaling. Defects in phosphorylation of tyrosine residues of intracellular substrates of the immunocytes are a noted phenomenon in glioma induced immune suppression. Administration of BRMs like Interleukin2 (IL-2), Interferon γ (IFN-γ) and SRBC in glioma induced experimental models, improved their survival status by immune potentiation. It was shown that SRBC exerts the maximum anti-tumor immune boosting by augmenting the functional status of the two immunocytes-microglia and lymphocytes when compared with IL-2 and IFN-γ. The present study focuses on the differential modulation of the protein tyrosine kinase activity in lymphocytes and microglia following the administration of the 3 BRMs. Our findings indicate that PTKs actively transduce signals on administration of exogenous IL-2. But exogenous IFN-γ administration fails to elicit the enzyme activity. With SRBC administration, a differential PTK activity modulation was observed in the two immunocytes. SRBC not only shifted the cytokine profile to Th 1 subset of lymphocytes but also simultaneously upregulated the expression of the activation marker IL-2Rα/CD25 thereby resulting in auto-activation of the hosts immunocytes.

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Teratogenic and Carcinogenic Effects in the Offspring after Single Injection of Ethylnitrosourea to Pregnant Rats

Cited by 251 publications

References 4 publications

Fibrinolytic Activity of Cultured Cells Derived During Ethylnitrosourea-induced Carcinogenesis of Rat Brain

Fibrinolytic Activity of Cultured Cells Derived During Ethylnitrosourea-induced Carcinogenesis of Rat Brain

Animal Models of Colorectal Cancer in Chemoprevention and Therapeutics Development

Differential regulation of the protein tyrosine kinase activity followingiInterleukin-2 (IL-2), Interferron gamma (IFN?) and SRBC administration in brain tumor induced conditions: SRBC acting as a dual potentiator in regulating the cytokine profile

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