Teratogenesis Induced by Trimethoprim Sulfamethoxazole in Mice

Arshad, M. I.; Asmatullah, Asmatullah; Ara, Chaman; Andleeb, Shagufta; Ahmad, Naveed

doi:10.17582/journal.pjz/2018.50.5.sc2

Cited by 1 publication

(2 citation statements)

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“…Antibiotics rank as one of the most commonly used and consumed pharmaceutical classes, with low levels widely detected in sewage treatment plants effluent, surface water, groundwater, and drinking water [69]. Trimethoprim/sulfamethoxazole has been the choice of antibiotic therapy for the last 30 years due to its effectiveness against both gram-negative and gram-positive bacteria [109]. However, as a result of the sequential blockade of multiple steps involved in microbial folate synthesis, trimethoprim/sulfamethoxazole can inhibit the formation of purines and, ultimately, DNA [68,110].…”

Section: Sulfamethoxazolementioning

confidence: 99%

“…However, as a result of the sequential blockade of multiple steps involved in microbial folate synthesis, trimethoprim/sulfamethoxazole can inhibit the formation of purines and, ultimately, DNA [68,110]. In addition, the compound can also cross the placenta and thus harm neonates due to its folic acid antagonist properties [109]. Low folate levels in seminal plasma are reported to be associated with increased sperm DNA damage [111].…”

Section: Sulfamethoxazolementioning

confidence: 99%

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Contaminants of Emerging Concern (CECs) and Male Reproductive Health: Challenging the Future with a Double-Edged Sword

Marcu

Keyser

Petrik

et al. 2023

Toxics

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Approximately 9% of couples are infertile, with half of these cases relating to male factors. While many cases of male infertility are associated with genetic and lifestyle factors, approximately 30% of cases are still idiopathic. Contaminants of emerging concern (CECs) denote substances identified in the environment for the first time or detected at low concentrations during water quality analysis. Since CEC production and use have increased in recent decades, CECs are now ubiquitous in surface and groundwater. CECs are increasingly observed in human tissues, and parallel reports indicate that semen quality is continuously declining, supporting the notion that CECs may play a role in infertility. This narrative review focuses on several CECs (including pesticides and pharmaceuticals) detected in the nearshore marine environment of False Bay, Cape Town, South Africa, and deliberates their potential effects on male fertility and the offspring of exposed parents, as well as the use of spermatozoa in toxicological studies. Collective findings report that chronic in vivo exposure to pesticides, including atrazine, simazine, and chlorpyrifos, is likely to be detrimental to the reproduction of many organisms, as well as to sperm performance in vitro. Similarly, exposure to pharmaceuticals such as diclofenac and naproxen impairs sperm motility both in vivo and in vitro. These contaminants are also likely to play a key role in health and disease in offspring sired by parents exposed to CECs. On the other side of the double-edged sword, we propose that due to its sensitivity to environmental conditions, spermatozoa could be used as a bioindicator in eco- and repro-toxicology studies.

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Section: Sulfamethoxazolementioning

confidence: 99%