Teratogen update: Fetal effects after in utero exposure to coumarins Overview of cases, follow‐up findings, and pathogenesis

Treatment and diagnosis of pulmonary embolism in pregnancy

“…Vitamin K embriyopatisi nazal hipoplazi, skolyoz, kısa proksimal uzuvlar ve kısa falankslarla karakterize anomaliye yol açar (37). Vitamin K embriyopatisi gebeliğin 6-9 haftalarında varfarine maruz kalan fetüsün %5 kadarında görülür (30).…”

Antiphospholipid Syndrome in Pregnancy

“…In high risk groups, such as women with mechanical heart valves, warfarin may be used in pregnancy, but only after organogenesis (6th-12th week) because of high risk of fetal malformations (3) . Warfarin treatment is however, also associated with spontaneous abortions, prematurity and CNS abnormalities (70) . As warfarin cross the placenta and subsequently affect fetal coagulation, there is a risk for bleeding complications in the fetus and during birth (71) .In the Cochrane review by Empson et al it was concluded that a combination therapy with heparin and aspirin may reduce pregnancy loss in women with APA by 54% (36) .…”

Supramolecular assembly of 2-aminobenzothiazole and N-[(2-oxo-2H-1-benzopyran-3-yl)carboxyl]phenethylamide donor-acceptor complex. A comparative study

“…25b It should be pointed out that, for all complexes studied herein, the shortest intercentroid distance corresponds to the interaction between the coumarin-lactone ring and the donor-benzenoid ring, furthermore, the mean interplanar distance between these two rings seems to define the magnitude of the CT interaction (3.50(3) Å and 399 nm, 3.5(2) Å and 406 nm, and 3.38(8) Å and 423 nm for the mean interplanar D-A distance and CTλ max of complexes 3, 4 and 5, respectively), in agreement with the results found in non heterocyclic D-A complexes. 15 The structural similarities between the H-bonded ABT-dimer and natural DNA base pairs, could help to explain the teratogen 26 and cytotoxic 27 activities as well as gene mutation protection activity 28 of several coumarin derivatives.…”