Terapia biológica: sobrevida y seguridad en padecimientos reumáticos. Resultados del Registro Nacional Biobadamex 1.0

Ventura‐Ríos, Lucio; Bañuelos-Ramírez, David; Hernández-Quiroz, María del Carmen; Román, Manuel Robles-San; Irazoque-Palazuelos, Fedra; Goycochea-Robles, María Victoria

doi:10.1016/j.reuma.2012.02.010

Cited by 17 publications

(3 citation statements)

References 18 publications

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“…[7][8][9] However, due to the large number of side effects elicited by these pharmaceuticals, patients have increasingly focused their attention on natural remedies. 10 Spirulina, a practically harmless cyanobacterium, has been demonstrated to have marked antioxidant activity in vivo and in vitro. [11][12][13] This is attributed to the synergistic action of its components such as antioxidant pigments, phycobiliproteins, carotenes, vitamins C and E, c-linolenic acid, and phenolic compounds.…”

Section: Introduction Imentioning

confidence: 99%

Antioxidant Effect ofSpirulina (Arthrospira) maximaon Chronic Inflammation Induced by Freund's Complete Adjuvant in Rats

Gutiérrez-Rebolledo¹,

Galár-Martínez²,

García-Rodríguez

et al. 2015

Journal of Medicinal Food

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One of the major mechanisms in the pathogenesis of chronic inflammation is the excessive production of reactive oxygen and reactive nitrogen species, and therefore, oxidative stress. Spirulina (Arthrospira) maxima has marked antioxidant activity in vivo and in vitro, as well as anti-inflammatory activity in certain experimental models, the latter activity being mediated probably by the antioxidant activity of this cyanobacterium. In the present study, chronic inflammation was induced through injection of Freund's complete adjuvant (CFA) in rats treated daily with Spirulina (Arthrospira) maxima for 2 weeks beginning on day 14. Joint diameter, body temperature, and motor capacity were assessed each week. On days 0 and 28, total and differential leukocyte counts and serum oxidative damage were determined, the latter by assessing lipid peroxidation and protein carbonyl content. At the end of the study, oxidative damage to joints was likewise evaluated. Results show that S. maxima favors increased mobility, as well as body temperature regulation, and a number of circulating leukocytes, lymphocytes, and monocytes in specimens with CFA-induced chronic inflammation and also protects against oxidative damage in joint tissue as well as serum. In conclusion, the protection afforded by S. maxima against development of chronic inflammation is due to its antioxidant activity.

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Section: Introduction Imentioning

confidence: 99%

Antioxidant Effect ofSpirulina (Arthrospira) maximaon Chronic Inflammation Induced by Freund's Complete Adjuvant in Rats

Gutiérrez-Rebolledo¹,

Galár-Martínez²,

García-Rodríguez

et al. 2015

Journal of Medicinal Food

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“…49 Real-life studies and Registries have confirmed these data. 50,55 With regard to infections, RCTs and observational studies reported a good safety profile of TNFi. However, even if well tolerated, TNFi are associated with an increased infective risk, including opportunistic infections.…”

Section: Tnf-inhibitorsmentioning

confidence: 99%

<p>An Update for the Clinician on Biologics for the Treatment of Psoriatic Arthritis</p>

Chimenti¹,

D’Antonio²,

Conigliaro³

et al. 2020

BTT

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Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy typically associated with psoriasis (PsO). The pathogenesis is strictly related to the association among the presence of genetic risk alleles and innate and acquired immune response with dramatic consequences on bone remodeling. Clinically, PsA patients may present heterogenicity of articular and periarticular manifestations that may be associated with the presence of comorbidities making treatment decision challenging in patients management. The identification of patient-targeted therapies is still a critical issue. Actually, several biological and synthetic drugs are promising in terms of efficacy and safety profile. National and international treatment recommendations support clinicians in the decision of the best treatment, although they may have limits basically related to updates and different outcomes included in the clinical studies evaluated. The aim of this narrative review is therefore to give guidance for clinicians for PsA patients treatment. For this purpose, we evaluated evidence on biological therapies efficacy used for PsA treatment. Specifically, we reviewed data on biological therapies, Janus kinases (JAK) inhibitors, and drugs with a new mechanism of action that are part of the treatment pipeline. The concept of "switching" and "swapping" is also described, as well as data concerning special populations such as pregnant women and elderly patients.

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“…In fact, the primary treatment involves the use of a combination of non-steroidal anti-inflammatory drugs, glucocorticosteroids, disease-modifying antirheumatic drugs, and biological therapies such as rituximab and infliximab [9]. This therapeutic approach is lengthy and focuses on inhibiting main mediators of the chronic inflammation process to regulate or reduce their degenerative impact on joint tissues [10]. Although these medications are effective, their long-term use in treating chronic inflammation is associated with undesirable side effects.…”

Section: Introductionmentioning

confidence: 99%

Effect of Siphonochilus aethiopicus Methanolic Extract on Oxidative Stress Markers, Biochemical and Hematological Parameters in Experimentally Induced Arthritis Model in Mice

Dadaya,

Vedekoi,

Zacharie

et al. 2024

Asian J. Res. Biochem.

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Background: Siphonochilus aethiopicus belongs to the Zingiberaceae family. In Chinese medicine, Zingiberaceae are acknowledged for their anti-inflammatory and antioxidant properties, which contribute to immune system reinforcement. They are known to promote digestion, alleviate nausea, motion sickness and are involved incombating flu and cold. The current study was conducted to investigate the antioxidant and anti-inflammatory properties of the methanolic extract of Siphonochilus aethiopicus (MESA). Methodology: The in vivo study examined the anti-inflammatory impact of the extract (75, 150, and 300 mg/kg) using a formaldehyde-induced inflammation mouse model. The anti-arthritic effect of the MESA was determined by measuring paw diameter, body weight, biochemical parameters (C-reactive protein and rheumatoid factor) including oxidative stress markers (malondialdehyde, superoxide dismutase, catalase, and nitric oxide), and hematological parameters. Additionally, a histopathological examination was conducted to evaluate the outcome of treatment on tissue integrity. Results: Results obtained show that the MESA significantly decreased paw inflammation (P < 0.05 to P < 0.001) and enhanced hematological and biochemical parameters. Additionally, MESA significantly ameliorated oxidative stress parameters (P < 0.05 to P < 0.001). Conclusion: This finding suggests that Siphonochilus aethiopicus possesses strong antioxidant and anti-arthritic activity, supporting its traditional application as a remedy for rheumatoid arthritis.

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Terapia biológica: sobrevida y seguridad en padecimientos reumáticos. Resultados del Registro Nacional Biobadamex 1.0

Cited by 17 publications

References 18 publications

Antioxidant Effect ofSpirulina (Arthrospira) maximaon Chronic Inflammation Induced by Freund's Complete Adjuvant in Rats

Antioxidant Effect ofSpirulina (Arthrospira) maximaon Chronic Inflammation Induced by Freund's Complete Adjuvant in Rats

<p>An Update for the Clinician on Biologics for the Treatment of Psoriatic Arthritis</p>

Effect of Siphonochilus aethiopicus Methanolic Extract on Oxidative Stress Markers, Biochemical and Hematological Parameters in Experimentally Induced Arthritis Model in Mice

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