Terahertz technology in diagnosis of glioma molecular markers

Abstract

Gliomas are invasive brain tumors with high rates of recurrence and mortality. It has been shown that specific markers for glioma’s differential diagnostics are enantiomers of 2-hydroxyglutarate (L-2HG and D-2HG) in brain tissues and blood. These isomers have unique absorption peaks originating from vibrational and rotational transitions in their molecules. In particular, the peaks centered at 1.337 THz and 1.695 THz correspond to L-2HG and D-2HG isomers, respectively. The goal of this work is to develop highly efficient frequency-selective sensors for L-2HG and D-2HG isomers using the effect of nanoantenna-assisted plasmonic enhancement of THz absorption. Such an approach provides a noticeable increase in detection sensitivity versus direct non-resonant methods. In this paper, we present the numerical results of the design optimization for L-2HG and D-2HG sensors based on Si/SiO2-wafer-backed arrays of golden nanoantennas of linear geometry. The optimal structural parameters of the arrays found through integral averaging of the square of the surface electric field over an array unit cell are recommended for further nanolithographic fabrication of this kind of THz sensor.

Design and fabrication of a potential biodetector based in gold nanoantennas array

“…Hence, the optical properties of plasmonic devices based on nanoantenna arrays were studied using infrared spectroscopy (FTIR) with Bruker Vertex 70 equipment, analyzing the absorbance as a function of frequency (THz), which allows us to de ne the resonance frequency of the device. Figure 3 shows that the resonance frequency (v res ) for the nanoantenna named spaceship presents one peak 33 THz [15].…”

Modeling of brain tumors using in vitro, in vivo, and microfluidic models: A review of the current developments

“…Moreover, it is worth noting that H3K27 M mutations were linked to unfavorable prognoses in certain pediatric gliomas. In addition, the presence of Telomerase Reverse Transcriptase (TERT) promoter mutations and Platelet-Derived Growth Factor Receptor Alpha (PDGFRA) markers offer valuable additional information regarding the behavior of gliomas and their potential for effective treatment strategies [ 15 ]. Utilizing these markers facilitates the customization of therapeutic approaches for individual patients, thereby enhancing the overall management and provision of care for individuals afflicted with glioma.…”

Study on terahertz absorption characteristics of bovine serum albumin aqueous solution via microfluidic technology

“… – 5 The traditional THz time-domain spectroscopy (THz-TDS) system represents a typical representative of THz technology. Kuznetsov et al 6 . detected molecular markers of glioma through THz technology.…”

“…[1][2][3][4][5] The traditional THz time-domain spectroscopy (THz-TDS) system represents a typical representative of THz technology. Kuznetsov et al 6 detected molecular markers of glioma through THz technology. Former investigations have shown that the specific marker for the differential diagnosis of glioma is 2-hydroxyglutaric acid (L-2HG and D-2HG) enantiomers in brain tissue and blood.…”