Terahertz sensing of highly absorptive water-methanol mixtures with multiple resonances in metamaterials

Chen, Min; Singh, Leena; Xu, Ningning; Singh, Ranjan; Zhang, Weili; Xie, Lijuan

doi:10.1364/oe.25.014089

Cited by 88 publications

(35 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the previous studies, the analyte is usually located in the whole area of the MM and the volume of the analyte is large [5][6][7][8][9][10][11][12][13][14][15][16][20][21][22][23][24][25][26][27]. If we don't consider the required sample volume, the resonance frequency shift per unit refractive index change in our study (72 GHz/RIU for the multichannel design, 223 GHz/RIU for the one big channel design) is comparable to previous studies (such as, 40 GHz/RIU [13], 220 GHz/RIU [20], 305 GHz/RIU [21]). Nevertheless, our proposed MMCMMB design requires much less sample volume, which is highly desirable for the very expensive and highly absorptive liquid samples.…”

Section: Experimental Details and Resultsmentioning

confidence: 99%

“…Moreover, the overlap of the electromagnetic fields and the sensing analytes can be further improved to achieve higher sensitivity [34]. As for the biosensing applications, the sensitivity and selectivity of the proposed design can be further improved by optimizing the structure parameters to match the resonant frequencies of the detected biological macromolecules and specific reaction between the biological target and binding agent immobilized onto the device [21].…”

Section: Experimental Details and Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Terahertz Microfluidic Metamaterial Biosensor for Sensitive Detection of Small-Volume Liquid Samples

Zhang

Chen

et al. 2019

IEEE Trans. THz Sci. Technol.

View full text Add to dashboard Cite

Metamaterial assisted terahertz (THz) label-free bio-sensing has promising applications. However, the sensitive THz detection of highly absorptive liquid samples remains challenging. Here, we present a novel multi-microfluidic-channel metamaterial biosensor (MMCMMB) for highly sensitive THz sensing of small volume liquid samples. The multi-channels are set mostly in the strong electric field enhancement area of the metamaterial, which significantly decreases the liquid amount and enhances interaction between the sensing targets and the THz wave (thus increasing the sensitivity). The sensing results of isopropyl alcohol (IPA)-water mixtures and bovine serum albumin (BSA) solutions based on the bow-tie array metamaterial with multi-channels demonstrate the effectiveness of this proposed design and the great potential in THz bio-sensing. This design has the advantages of being highly sensitive, label-free, cost-effective, easy to operate and only needing a tiny liquid volume. Thus our device provides a robust route for metamaterial assisted THz label-free bio-sensing of liquid-based substances. IndexTerms-Terahertz spectroscopy, biomedical spectroscopy, metamaterial, microfluidic.

show abstract

Section: Experimental Details and Resultsmentioning

confidence: 99%

Section: Experimental Details and Resultsmentioning

confidence: 99%

Terahertz Microfluidic Metamaterial Biosensor for Sensitive Detection of Small-Volume Liquid Samples

Zhang

Chen

et al. 2019

IEEE Trans. THz Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…34 Earlier reports using the THz metamaterial for sensing of sugars, 35 yeast, 36 virus, 37,38 and other biomaterials 39,40 have been carried out under dehydrated conditions. 41 Few studies have demonstrated sensing with THz metamaterial in aqueous environment by confining aqueous solution at the microscale level. 34,[42][43][44][45] However, further reduction of the analyte volume to the nanoscale level would aid in much higher sensitivity of detection as the absorption from water could be greatly reduced.…”

mentioning

confidence: 99%

Nanofluidic terahertz metasensor for sensing in aqueous environment

Shih

Pitchappa

Jin

et al. 2018

Applied Physics Letters

Self Cite

107

View full text Add to dashboard Cite

The terahertz spectral region has received tremendous attention for label free chemical and biological sensing, due to the presence of molecular fingerprints, low energy characteristics, and remote sensing capabilities. However, a major hindrance for the realization of a high performance terahertz bio-chemical sensor comes from the large absorption of terahertz waves by aqueous solution. Here, we overcome this limitation by confining the analyte-aqueous solution in a nanovolumetric fluidic chamber, integrated on metamaterial resonant cavities. The metamaterial resonators confine electromagnetic fields in extremely subwavelength space and hence allow for the enhanced interaction between the nanovolumetric analyte-aqueous solution and terahertz waves, while minimizing the absorption loss. We compare the sensing performance of split ring resonator and Fano resonator systems as metamaterial resonators. As a demonstration of chemical sensing, three alcoholic solutions with different concentrations were measured. Selective adenosine triphosphate (ATP) sensing capability was examined through ATP aptamer functionalization on gold metamaterials, where a decrease in the transmittance value was observed as the ATP concentration increased. The proposed sensing approach has the potential to be an effective tool for molecular analysis through exploiting the advantages offered by low energy terahertz, subwavelength metamaterial resonators and nanofluidic technologies.

show abstract

“…The transmission spectrum was measured along different polarization axes, confirming the polarization‐independent behavior expected for a structure with C 4 symmetry. However, the miniaturization factor reduced to 18.63 due to the slight shift in resonant frequency, nevertheless this is the highest miniaturization factor achieved for polarization‐independent THz metamaterial resonator 45–50,64–73. It is worth mentioning that in this design the Q factor was mainly affected by the density of the unit cells.…”

Section: Experimental Verificationmentioning

confidence: 87%

Dual‐Region Resonant Meander Metamaterial

Manjunath

Liu

Raj

et al. 2020

Advanced Optical Materials

View full text Add to dashboard Cite

Metamaterials are engineered structures designed to interact with electromagnetic radiation, whereby the frequency range in which metamaterials respond depends on their dimensions. In this paper, it is demonstrated that a metamaterial can be functional in more than one frequency region. An advanced metamaterial is demonstrated that can interact with both terahertz (THz) and near‐infrared (NIR) frequencies, concurrently. This work exploits meander line resonators with nanoscale linewidth distributed over microscale areas, and experimentally demonstrates that such a metamaterial can simultaneously interact with NIR and THz waves. The engineered metamaterial acts as a plasmonic grating in the NIR range and simultaneously acts as an array of electric resonators in the THz range. Moreover, the performance of the engineered metamaterial is polarization‐independent in both wavelength regions. Finally, a unique feature of the proposed metamaterial is that it enables resonant frequency tuning in the THz region without affecting the NIR response. All these novel advantages of dual‐band meander metamaterial make it an ideal alternative for cutting‐edge applications such as bi‐functional sensing, imaging, filtering, modulation, and absorption.

show abstract

Terahertz sensing of highly absorptive water-methanol mixtures with multiple resonances in metamaterials

Cited by 88 publications

References 44 publications

Terahertz Microfluidic Metamaterial Biosensor for Sensitive Detection of Small-Volume Liquid Samples

Terahertz Microfluidic Metamaterial Biosensor for Sensitive Detection of Small-Volume Liquid Samples

Nanofluidic terahertz metasensor for sensing in aqueous environment

Dual‐Region Resonant Meander Metamaterial

Contact Info

Product

Resources

About