This study focuses on the synthesis of amodiaquine dihydrochloride dihydrate and evaluates the performance of a new process against existing methods using several key indicators. The target compounds were synthesized successfully through experimental design and data collection, with their quality thoroughly assessed. Results indicate that the new process significantly enhances yield, purity, and crystal structure. Also, by utilizing highly efficient catalysts and finely tuning reaction conditions, the improvements in yield and purity are substantial. The new process not only enhances production efficiency but also significantly reduces waste, aligning well with the principles of green chemistry. Additionally, this paper discusses the potential industrial application of the new process. Despite facing challenges such as equipment costs, scale-up, and market acceptance in its industrialization, the new process's superior performance and promising prospects provide a strong foundation for its future implementation.