Terahertz Microscope Based on Solid Immersion Effect for Imaging of Biological Tissues

Chernomyrdin, Nikita V.; Kucheryavenko, Anna S.; Rimskaya, Elena N.; Dolganova, Irina N.; Zhelnov, Vladislav A.; Каралкин, П. А.; Gryadunova, A. A.; Reshetov, Igor V.; Lavrukhin, D. V.; Пономарев, Д. С.; Karasik, Valeriy E.; Zaytsev, Kirill I.

doi:10.1134/s0030400x19050059

Cited by 19 publications

(6 citation statements)

References 54 publications

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“…On the one hand, these two components serve as separate mechanical elements, one of which (the hypohemisphere) is rigidly fixed, while the other (the window) serves as a sample holder being mounted onto an xy motorized translation stage; on the other hand, they form a unitary optical element-a HRFZ-Si hemisphere. The described THz solid immersion lens was applied to the reflection-mode imaging of different biological objects, among them a leaf, cell-spheroids, connective fibrous tissues of the breast ex vivo (see figure 5) [109], and muscle tissues of the tongue ex vivo (see figures 20(b) and (c)) [394]. The observed images reveal the sub-wavelength structural elements of tissues, promising new applications of the THz solid immersion microscopy in biology and medicine.…”

Section: Terahertz-wave Delivery To Difficult-to-access Tissue and In...mentioning

confidence: 99%

The progress and perspectives of terahertz technology for diagnosis of neoplasms: a review

Zaytsev

Dolganova

Chernomyrdin

et al. 2019

J. Opt.

161

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Over the past few decades, significant attention has been paid to the biomedical applications of terahertz (THz) technology. Nowadays, THz spectroscopy and imaging have allowed numerous demanding problems in the biological, medical, food, plant and pharmaceutical sciences to be solved. Among the biomedical applications, the label-free diagnosis of malignant and benign neoplasms represents one of the most attractive branches of THz technology. Despite this attractiveness, THz diagnosis methods are still far from being ready for use in medical practice. In this review, we consider modern research results in the THz diagnosis of malignant and benign neoplasms, along with the topical research and engineering problems which restrain the translation of THz technology to clinics. We start by analyzing the common models of THz-wave-tissue interactions and the effects of tissue exposure to THz waves. Then, we discuss the existing modalities of THz spectroscopic and imaging systems, which have either already been applied in medical imaging, or hold strong potential. We summarize the earlier-reported and original results of the THz measurements of neoplasms with different nosology and localization. We pay attention to the origin of contrast between healthy and pathological tissues in the THz spectra and images, and discuss the prospects of THz technology in

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Section: Terahertz-wave Delivery To Difficult-to-access Tissue and In...mentioning

confidence: 99%

The progress and perspectives of terahertz technology for diagnosis of neoplasms: a review

Zaytsev

Dolganova

Chernomyrdin

et al. 2019

J. Opt.

161

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“…1). Namely, structural heterogeneities of intact and pathologically-altered tissues lead to the mesoscale spatial fluctuations of the THz optical properties of tissues, which gives rise to the Mie scattering of the THz waves 189,190 . These scattering effects can either hamper the THz diagnosis or provide additional useful information for the tissue quantification 41,116 .…”

Section: Prospects and Challenging Problemsmentioning

confidence: 99%

“…Development of a correct physical model to describe the THz-wave transport in tissues with such scatterers remains an important problem of THz biophotonics. For this aim the Mie scatter-ing theory and the radiation transfer theory can be adapted 189,190 .…”

Section: Prospects and Challenging Problemsmentioning

confidence: 99%

Terahertz technology in intraoperative neurodiagnostics: A review

Chernomyrdin¹,

Musina²,

Никитин³

et al. 2023

OEA

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Terahertz (THz) technology offers novel opportunities in biology and medicine, thanks to the unique features of THzwave interactions with tissues and cells. Among them, we particularly notice strong sensitivity of THz waves to the tissue water, as a medium for biochemical reactions and a main endogenous marker for THz spectroscopy and imaging. Tissues of the brain have an exceptionally high content of water. This factor, along with the features of the structural organization and biochemistry of neuronal and glial tissues, makes the brain an exciting subject to study in the THz range. In this paper, progress and prospects of THz technology in neurodiagnostics is overviewed, including diagnosis of neurodegenerative disease, myelin deficit, tumors of the central nervous system (with an emphasis on brain gliomas), and traumatic brain injuries. Fundamental and applied challenges in study of the THz-wave -brain tissue interactions and development of the THz biomedical tools and systems for neurodiagnostics are discussed.

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“…As examples of such heterogenous tissues, one can consider results of THz microscopy of individual fat cells embedded into fibrous connective mammary gland ex vivo, as well as muscle fibers of the tongue ex vivo from Ref. [32]. For such structural inhomogeneities of tissues, one can expect Mie scattering of THz waves [33], in contrast to the Rayleigh scattering regime considered in the effective medium theory [34].…”

Section: Terahertz Biophotonicsmentioning

confidence: 99%

Prospects of terahertz technology in diagnosis of human brain tumors – A review

Musina

Никитин

Chernomyrdin

et al. 2020

J-BPE

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Terahertz (THz) waves feature high sensitivity to the content and state of water in biological tissues. Therefore, during the past decades, THz technology has attracted significant attention in biophotonics, including diagnosis of malignant and benign neoplasms with different nosologies and localizations. The pathophysiological features of malignant tumors of the central nervous system determine appearance of several morphological phenomena, such as increased vascularity, edema, necrosis. These phenomena cause water content increase in the studied tissues and, thus, open new ways for the THz technology applications in the intraoperative neurodiagnosis, including delineation of tumor margins. This research area is rather novel and, despite the small amount of accumulated research material, is undoubtedly extremely promising for creation of new diagnostic approaches. In this review, available results in the considered exciting branch of THz technology are summarized, and potential projections of this topic into the future are constructed.

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Terahertz Microscope Based on Solid Immersion Effect for Imaging of Biological Tissues

Cited by 19 publications

References 54 publications

The progress and perspectives of terahertz technology for diagnosis of neoplasms: a review

The progress and perspectives of terahertz technology for diagnosis of neoplasms: a review

Terahertz technology in intraoperative neurodiagnostics: A review

Prospects of terahertz technology in diagnosis of human brain tumors – A review

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