Terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiation in vitro

Zhao, Xianghui; Zhang, Ming; Liu, Yuming; Liu, Haiying; Ren, Keke; Xue, Qingyun; Zhang, Haifeng; Zhi, Na; Wang, Wenting; Wu, Shengxi

doi:10.1016/j.isci.2021.103485

Cited by 16 publications

(22 citation statements)

References 38 publications

(40 reference statements)

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“…The non-invasive procedure for imaging could capacitate for real-time in-vivo cancer detection and diagnosis, regular screening and patient monitoring [13]. This hypothesis is supported by several previously reported investigations whereby safe exposure levels have been achieved on the basal keratinocytes [15], on blood leukocytes [16] as well as mammalian cells of humans.…”

Section: Introductionsupporting

confidence: 55%

Terahertz Imaging and Sensing for Healthcare: Current Status and Future Perspectives

Gezimati

Singh

2023

IEEE Access

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There is a keen interest in the exploration of new generation emitters and detectors due to advancements in innovation of new materials and device processing technologies which have opened up new frontiers in the Terahertz (THz) spectrum. Therefore, it is necessary to review the developments in THz technology for healthcare applications, their impact, implications and prospects for ongoing research and development. This paper provides a broad overview of the current status and prospects of application of THz imaging and sensing for the healthcare domain. We present current knowledge, identify existing challenges for wide scale clinical adoption of THz systems and prospective opinions to facilitate research and development towards optimized and miniaturized THz systems and biosensors that provide real operational convenience through emerging trends. Firstly, we provide an overview of the THz imaging and sensing techniques that exploit properties of THz generation and detection with emphasis on terahertz time domain spectroscopy (THz-TDS) and THz Metamaterials. The mechanisms of tissue image contrast and the application of THz imaging and sensing for biomedical applications in particular, the cancer detection application is reported. Secondly, an outlook toward the advancements in THz technology in the interface of healthcare 4.0 and its enabling technologies is explored for next generation smart and connected healthcare systems. Third, we identify the merits and existing challenges in THz cancer imaging and sensing and suggest prospective opinions to pave way to ongoing and future research. Further, we discuss the recent advances in THz imaging development and the contribution of near-field techniques based on plasmonic, and resonance based metasurfaces, waveguides etc. for breaking the diffraction limit towards development of THz systems that are convenient for point of care. We bring researchers a roadmap for future research scope.

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Section: Introductionsupporting

confidence: 55%

Terahertz Imaging and Sensing for Healthcare: Current Status and Future Perspectives

Gezimati

Singh

2023

IEEE Access

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“…However, only a few studies deal with the effects of THz radiation on the nervous system cells. For instance, Zhao et al, showed that THz radiation inhibited the proliferation of progenitors of mouse oligodendrocytes, but stimulated their differentiation in the mature forms with the following myelination of fibers [ 17 ]. An extensive study by Tan Sheng Zhi et al, showed that different neuron types, in both normal and tumor rodent cell lines, were distinct in their sensitivity to THz radiation [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Sensitivity of Neuroblastoma and Induced Neural Progenitor Cells to High-Intensity THz Radiation

Ситников

Revkova

Ilina

et al. 2023

IJMS

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THz radiation induces a variety of processes in cells and has attracted the attention of researchers in recent decades. Here, data on the effects of high-intensity terahertz (THz) radiation on human directly reprogrammed neural progenitor cells (drNPCs) and on neuroblastoma cells (SK-N-BE (2)) were obtained for the first time. The results demonstrated that the exposure of non-tumor and tumor cells to broadband (0.1–3 THz) THz pulses with the intensity of 21 GW/cm2 and the electric field strength of 2.8 MV/cm for 30 min induced neither a noticeable genotoxic effect nor a statistically significant change in the proliferative activity and cell differentiation. It was also shown that the combined effect of THz radiation and salinomycin, a promising antitumor agent, on neuroblastoma cells did not enhance the genotoxic effect of this antibiotic. However, further studies involving chemotherapy drugs and other exposure parameters are warranted to introduce this new concept into anti-tumor clinical practice and to enhance the efficacy of the existing approaches.

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“…Many studies verified that THz waves with different radiation frequencies, intensities, and time of exposure shed different effects on the functions (e.g., gene expression, synaptic transmission, and immune cytokines release) of the nervous system [30][31][32]. Also, the THz waves could cause structural changes of macromolecules (e.g., proteins, lipid membranes) in living cells [24,33].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Cancer Cell Migration and Glycolysis by Terahertz Wave Modulation via Altered Chromatin Accessibility

Sun

Li²,

Yu³

et al. 2022

Research

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Metastasis and metabolic disorders contribute to most cancer deaths and are potential drug targets in cancer treatment. However, corresponding drugs inevitably induce myeloid suppression and gastrointestinal toxicity. Here, we report a nonpharmaceutical and noninvasive electromagnetic intervention technique that exhibited long-term inhibition of cancer cells. Firstly, we revealed that optical radiation at the specific wavelength of 3.6 μm (i.e., 83 THz) significantly increased binding affinity between DNA and histone via molecular dynamics simulations, providing a theoretical possibility for THz modulation- (THM-) based cancer cell intervention. Subsequent cell functional assays demonstrated that low-power 3.6 μm THz wave could successfully inhibit cancer cell migration by 50% and reduce glycolysis by 60%. Then, mRNA sequencing and assays for transposase-accessible chromatin using sequencing (ATAC-seq) indicated that low-power THM at 3.6 μm suppressed the genes associated with glycolysis and migration by reducing the chromatin accessibility of certain gene loci. Furthermore, THM at 3.6 μm on HCT-116 cancer cells reduced the liver metastasis by 60% in a metastatic xenograft mouse model by splenic injection, successfully validated the inhibition of cancer cell migration by THM in vivo. Together, this work provides a new paradigm for electromagnetic irradiation-induced epigenetic changes and represents a theoretical basis for possible innovative therapeutic applications of THM as the future of cancer treatments.

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Terahertz exposure enhances neuronal synaptic transmission and oligodendrocyte differentiation in vitro

Cited by 16 publications

References 38 publications

Terahertz Imaging and Sensing for Healthcare: Current Status and Future Perspectives

Terahertz Imaging and Sensing for Healthcare: Current Status and Future Perspectives

Sensitivity of Neuroblastoma and Induced Neural Progenitor Cells to High-Intensity THz Radiation

Inhibition of Cancer Cell Migration and Glycolysis by Terahertz Wave Modulation via Altered Chromatin Accessibility

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