Terahertz dynamic imaging of skin drug absorption

Kim, Kyung Won; Kim, Kwang Sung; Kim, Hyeongmun; Lee, Sang-Hun; Park, Jae Hak; Han, Ju Hee; Seok, Seonho; Park, Jisuk; Choi, Yoon Seok; Kim, Young Il; Han, Joon Koo; Son, Joo‐Hiuk

doi:10.1364/oe.20.009476

Cited by 48 publications

(25 citation statements)

References 20 publications

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“…In addition to THz in vivo imaging, this modality has been expanded to many other medical fields. For instance, drug tracing within the skin [80], cartilage damage imaging [81], and skeletal computed tomography [82] have been performed. These trials have attracted intensive attention and support prospective application of this technique in clinical settings.…”

Section: Current Status Of Thz Imaging Studiesmentioning

confidence: 99%

Biomedical Applications of Terahertz Spectroscopy and Imaging

Xiang

Zhao

Yang

et al. 2016

Trends in Biotechnology

719

371

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Section: Current Status Of Thz Imaging Studiesmentioning

confidence: 99%

Biomedical Applications of Terahertz Spectroscopy and Imaging

Xiang

Zhao

Yang

et al. 2016

Trends in Biotechnology

719

371

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“…THz imaging with pulsed radiation has been used for mapping images using the maximum (E max ) and minimum (E min ) of a THz temporal signal (E(t)) or using a refractive index and absorption coefficient of a THz spectral signal E(ω) [29][30][31][32][33]. For example, liver cancer samples embedded in paraffin yielded a 4% difference between the E(ω) signals acquired from normal and cancerous tissues, and cancerous regions were clearly detectable in these samples [22].…”

Section: Results and Analysismentioning

confidence: 99%

Terahertz imaging of metastatic lymph nodes using spectroscopic integration technique

Park

Choi

Cheon

et al. 2017

Biomed. Opt. Express

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Terahertz (THz) imaging was used to differentiate the metastatic states of frozen lymph nodes (LNs) by using spectroscopic integration technique (SIT). The metastatic states were classified into three groups: healthy LNs, completely metastatic LNs, and partially metastatic LNs, which were obtained from three mice without infection and six mice infected with murine melanoma cells for 30 days and 15 days, respectively. Under histological examination, the healthy LNs and completely metastatic LNs were found to have a homogeneous cellular structure but the partially metastatic LNs had interfaces of the melanoma and healthy tissue. THz signals between the experimental groups were not distinguished at room temperature due to high attenuation by water in the tissues. However, a signal gap between the healthy and completely metastatic LNs was detected at freezing temperature. The signal gap could be enhanced by using SIT that is a signal processing method dichotomizing the signal difference between the healthy cells and melanoma cells with their normalized spectral integration. This technique clearly imaged the interfaces in the partially metastatic LNs, which could not be achieved by existing methods using a peak point or spectral value. The image resolution was high enough to recognize a metastatic area of about 0.7 mm size in the partially metastatic LNs. Therefore, this pilot study demonstrated that THz imaging of the frozen specimen using SIT can be used to diagnose the metastatic state of LNs for clinical application.

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“…Suitability of terahertz (THz) imaging for nondestructive testing [1], biomedical research [2] or food and pharmaceutical industry [3] stimulates a search for compact and practically convenient solutions. It can be assumed that development of compact THz diffractive optics components, which enable massive parabolic mirrors to be replaced by much more attractive flat compact optical elements, is a particularly important issue [4,5].…”

Section: Introductionmentioning

confidence: 99%

Compact diffractive optics for THz imaging

Minkevičius¹,

Indrišiūnas²,

Šniaukas³

et al. 2018

physics

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We present a compact diffractive silicon-based multilevel phase Fresnel lens (MPFL) with up to 50 mm in diameter and a numerical aperture up to 0.86 designed and fabricated for compact terahertz (THz) imaging systems. The laser direct writing technology based on a picosecond laser was used to fabricate diffractive optics on silicon with a different number of phase quantization levels P reaching an almost kinoform spherical surface needed for efficient THz beam focusing. Focusing performance was investigated by measuring Gaussian beam intensity distribution in the focal plane and along the optical axis of the lens. The beam waist and the focal depth for each MPFL were evaluated. The influence of the phase quantization number on the focused beam amplitude was estimated, and the power transmission efficiency reaching more than 90% was revealed. The THz imaging of less than 1 mm using a robust 50 mm diameter multilevel THz lens was achieved and demonstrated at 580 GHz frequency.

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Terahertz dynamic imaging of skin drug absorption

Cited by 48 publications

References 20 publications

Biomedical Applications of Terahertz Spectroscopy and Imaging

Biomedical Applications of Terahertz Spectroscopy and Imaging

Terahertz imaging of metastatic lymph nodes using spectroscopic integration technique

Compact diffractive optics for THz imaging

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