Teprotumumab vs Intravenous Methylprednisolone for Thyroid Eye Disease

Campbell, Ashley A.

doi:10.1001/jamaophthalmol.2021.6376

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Teprotumumab is a fully human monoclonal antibody targeting the IGF-IR. It was found to be useful in improving the proptosis, diplopia, and quality of life of TED patients [50,52 ▪▪ ,53,61,62,63 ▪▪ ]. Tocilizumab, which blocks interleukin 6 (IL-6), also demonstrated efficacy in improving the extraocular motility in 83.33%, and diplopia in 53.85% of TED patients [53,54].…”

Section: Thyroid Eye Diseasementioning

confidence: 99%

Nonneurologic causes of binocular diplopia for the neurologist

Mosleh¹,

Peragallo

2022

Current Opinion in Neurology

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Purpose of reviewTo review several etiologies of nonneurologic diplopia that the neurologist should be familiar with. The pathophysiology, clinical presentation, neuroimaging findings, and treatment options are briefly summarized for each condition. Recent findingsCertain etiologies for diplopia can be associated with life-threatening neurologic conditions and should be investigated thoroughly for proper localization and immediate management of the underlying disease. However, nonneurological causes of binocular diplopia are very common and disabling, but are often nonemergent and may not require in-depth investigation or neuroimaging. Some of the etiologies of nonneurologic diplopia mimic cranial nerve palsies, making them confusing to evaluate when the physician is not familiar with these etiologies. Unfamiliarity with these diagnoses can lead to unnecessary neuroimaging, inefficient utilization of medical resources, and undue alarm to the patient. Recent advances in clinical diagnostic tools and neuroimaging have clarified our understanding of the diverse underlying mechanisms of nonneurologic binocular diplopia. SummaryDiplopia can be a difficult symptom for the neurologist to evaluate. A systematic approach to the evaluation of diplopia can help establish the urgency and necessity of an extensive workup. This review will help to familiarize the neurologist with nonneurological causes of binocular diplopia, minimize expensive and unnecessary evaluations, and reassure patients and physicians alike.

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Section: Thyroid Eye Diseasementioning

confidence: 99%