Tepotinib plus osimertinib in patients with EGFR-mutated non-small-cell lung cancer with MET amplification following progression on first-line osimertinib (INSIGHT 2): a multicentre, open-label, phase 2 trial

Wu, Yi-Long; Guarneri, Valentina; Voon, Pei Jye; Lim, Boon Khaw; Yang, Jin-Ji; Wislez, Marie; Huang, Cheng; Liam, Chong Kin; Mazieres, Julien; Tho, Lye Mun; Hayashi, Hidetoshi; Nhung, Nguyen Viet; Chia, Puey Ling; de Marinis, Filippo; Raskin, Jo; Zhou, Qinghua; Finocchiaro, Giovanna; Le, Anh Tuan; Wang, Jialei; Dooms, Christophe; Kato, Terufumi; Nadal, Ernest; Hin, How Soon; Smit, Egbert F; Wermke, Martin; Tan, Daniel; Morise, Masahiro; O'Brate, Aurora; Adrian, Svenja; Pfeiffer, Boris M; Stroh, Christopher; Juraeva, Dilafruz; Strotmann, Rainer; Goteti, Kosalaram; Berghoff, Karin; Ellers-Lenz, Barbara; Karachaliou, Niki; Le, Xiuning; Kim, Tae Min

doi:10.1016/s1470-2045(24)00270-5

The Lancet Oncology

2024

DOI: 10.1016/s1470-2045(24)00270-5

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Tepotinib plus osimertinib in patients with EGFR-mutated non-small-cell lung cancer with MET amplification following progression on first-line osimertinib (INSIGHT 2): a multicentre, open-label, phase 2 trial

Yi-Long Wu,

Valentina Guarneri,

Pei Jye Voon

et al.

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Unveiling the Role of HGF/c-Met Signaling in Non-Small Cell Lung Cancer Tumor Microenvironment

Yao,

Liu,

Feng

et al. 2024

IJMS

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Non-small cell lung cancer (NSCLC) is characterized by several molecular alterations that contribute to its development and progression. These alterations include the epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), human epidermal growth factor receptor 2 (HER2), and mesenchymal–epithelial transition factor (c-MET). Among these, the hepatocyte growth factor (HGF)/c-MET signaling pathway plays a crucial role in NSCLC. In spite of this, the involvement of the HGF/c-MET signaling axis in remodeling the tumor microenvironment (TME) remains relatively unexplored. This review explores the biological functions of the HGF/c-MET signaling pathway in both normal and cancerous cells, examining its multifaceted roles in the NSCLC tumor microenvironment, including tumor cell proliferation, migration and invasion, angiogenesis, and immune evasion. Furthermore, we summarize the current progress and clinical applications of MET-targeted therapies in NSCLC and discuss future research directions, such as the development of novel MET inhibitors and the potential of combination immunotherapy.

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Unveiling the Role of HGF/c-Met Signaling in Non-Small Cell Lung Cancer Tumor Microenvironment

Yao,

Liu,

Feng

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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Tepotinib plus osimertinib in patients with EGFR-mutated non-small-cell lung cancer with MET amplification following progression on first-line osimertinib (INSIGHT 2): a multicentre, open-label, phase 2 trial

Cited by 1 publication

References 27 publications

Unveiling the Role of HGF/c-Met Signaling in Non-Small Cell Lung Cancer Tumor Microenvironment

Unveiling the Role of HGF/c-Met Signaling in Non-Small Cell Lung Cancer Tumor Microenvironment

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