Teohnetium Tc 99m Sestamibi Scan for Localizing Abnormal Parathyroid Glands After Previous Neck Operations

Recurrence of secondary hyperparathyroidism in patients after total parathyroidectomy with autotransplantation: technical and therapeutic aspects

“…Notably, the MIBI-Scintigraphy plays an important role in pre-operative diagnostic procedure, whereas positive localization rate in the forearm with MIBI-Scintigraphy is reported between 69 and 100% [15,18]. In our study, successful localization rate in the forearm with MIBIScintigraphy and iPTH measurement was 75% (9/12).…”

Persistent and Recurrent Hyperparathyroidism After Total Parathyroidectomy With Autotransplantation

“…The large number of mitochondria present in cells of parathyroid adenomas may be responsible for the abundant uptake and slow release of MIBI for these cells. 6 Before reoperation, MIBI scanning has been reported to show a range of successful localization rates: Majors et al 15 reported a 100% preoperative localization rate in 9 patients, Weber et al 16 reported a 88% localization rate in 16 patients, Rodriquez et al 17 reported a 60% localization rate, and Peeler et al 7 reported that 69% were localized before surgery. In this study, 11 of 13 (84.6%) were localized before surgery.…”

Parathyroid re-exploration

“…In the early 1990s there was considerable interest in sestamibi scanning as a preoperative localization test in routine parathyroidectomy, which had a success rate exceeding 90%. This success rate led to parathyroid surgery being considered an easy surgical procedure if the gland was localized with a sestamibi scan [9][10][11][12][13][14][15]. The other localization studies, such as ultrasound, Thallium-Technetium scan, CT, and MRI, did not have such high accuracy, and soon they were rarely used in parathyroid exploration.…”