Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration

Chen, Huaiyang; Duncan, Ian C.; Bozorgchami, Hormozd; Lo, Su Hao

doi:10.1073/pnas.022518699

Cited by 133 publications

(151 citation statements)

References 33 publications

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“…1A). 16,17 Variants 1 and 2 are 1419-and 1409-amino-acid proteins, respectively. Each comprises a C1 domain of protein kinase C at the N terminus followed by a PTEN (phosphatase and tensin homolog deleted from chromosome 10) homology region and SH2 (src homology 2) and PTB (phosphotyrosine binding) domains at the C terminus.…”

Section: Resultsmentioning

confidence: 99%

“…Tensin2 variant 3 (variant 3) has been shown to promote cell migration 16 and possibly is related to cell invasion, in the present study, we focused on the study of variant 3 in HCC, particularly its role in metastasis of HCC. Clinicopathological analysis of variant 3 expression revealed that overexpression of variant 3 in tumor tissue was associated with a more aggressive tumor phenotype and metastasis-related pathological features.…”

mentioning

confidence: 99%

“…Tensin2 was identified in a search for tensin family members that share extensive sequence homology with tensin1. 16 Tensin2 has been reported to localize at the end of actin stress fibers and to colocalize with vinculin and tensin1 at the focal adhesions in NIH3T3 cells. Tensin2 was also found to interact with the Axl receptor tyrosine kinase.…”

mentioning

confidence: 99%

“…The shortest splice variant of tensin2, variant 3, has been shown to promote cell migration. 16 Another family member, tensin3, is a component of epidermal growth factor-mediated signaling pathway. 18 Cten, a COOH-terminal tensinlike member with restricted expression in prostate and placenta was shown to be down-regulated in prostate cancer.…”

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confidence: 99%

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Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma

Yam

Chan

et al. 2006

Hepatology

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Tensins are a new family of proteins that act as an important link among extracellular matrix, actin cytoskeleton, and signal transduction and have been implicated in human cancers. Tensin2 was initially identified in a search for new tensin family members that share extensive sequence homology with tensin1. Tensin2 was highly expressed in liver tissues. A recent study reported that one of the splicing variants of tensin2, variant 3, promotes cell migration. In the present study, we aimed to elucidate the role of H epatocellular carcinoma (HCC) is one of the major malignancies worldwide and the second most common fatal cancer in Asia and Hong Kong. The molecular mechanisms underlying the development, invasion, and metastasis of HCC are areas of active research. A better understanding of these areas may lead to the development of more effective prognostic markers and potential therapies for HCC. Adhesion proteins including intracellular adhesion molecule 1, 1 E-cadherin, 2 CD44 variants, 3 and extracellular matrix protein, laminin-5 4 have been reported to be biomarkers for an invasive and metastatic phenotype of HCC. Proteinases responsible for the degradation of extracellular matrix, for instance, matrix metalloproteinase, 5 urokinase-type plasminogen activator, 6 uPA receptor, and uPA inhibitor, 7 are also important factors involved in the invasiveness and metastasis of HCC. Angiogenesis regulators critical to HCC metastasis has drawn a lot of attention in recent years. Vascular endothelial growth factor, 8 angiopoietin, 9 basic fibroblast growth factor, 10 platelet-derived endothelial cell growth factor, 11 and thrombospondin 12 have been reported to be angiogenic factors crucial to HCC angiogenesis.Tensin is a new family of focal adhesion proteins that act as an important link among extracellular matrix (ECM), actin cytoskeleton, and signal transduction. 13 Recent studies have revealed that tensin proteins are also implicated in human cancers. Tensin1 is the most wellcharacterized member and best known for its activity in organizing the actin cytoskeleton and mediating signal transduction. 13 Expression of human tensin1 was shown to be down-regulated in prostate and breast cancer cell From the

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma

Yam

Chan

et al. 2006

Hepatology

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“…One protein that we identified, tensin2, is a putative cytoskeletal protein related in structure to tensin (5). Tensin is an interesting protein that is recruited to focal adhesions early during their formation.…”

Section: Taskmentioning

confidence: 99%