Neutron-irradiated vanadium alloys were evaluated for their susceptibility to irradiation hardening, helium embrittlement, swelling, and residual radioactivity, and the results were compared with those for the austenitic and ferritic stainless steels. The VANSTAR-7 and V-15Cr-5T± alloys showed the greatest hardening between 400 and 600°C while V-3Ti-ISi and V-20Ti had lower values that were comparable to those of ferritic steels. The V-15Cr-5Ti and VANSTAR-7 alloys were susceptible to helium embrittlament caused by the combination of weakened grain boundaries and irradiation-hardened grain matrices. Specimen fractures were entirely intergranular in the most severe instances of embrittlement. The V-3Ti-ISi and V-20Ti alloys were more resistant to helium embrittlement. Except for VANSTAR-7 irradiated to 40 dpa at 520°C, all of the vanadium alloys exhibited low swelling that was similar to the ferritic steels. Swelling was greater in specimens that were preimplanted with helium using the tritium, trick. The vanadium alloys clearly exhibit lower residual radioactivity after irradiation than the ferrous alloys.