Tenomodulin regulated the compartments of embryonic and early postnatal mouse masseter muscle

Sato, Iwao; Miwa, Yoko; Hara, Setsuhiro; Fukuyama, Yasuro; Sunohara, Masataka

doi:10.1016/j.aanat.2014.07.001

Cited by 3 publications

(4 citation statements)

References 30 publications

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“…The first northern blot analysis on new-born mouse tissue showed the highest expression of Tnmd in skeletal muscle (Shukunami et al 2001), diaphragm and eye, even though an overall weak signal was visible in almost all other screened tissues (Brandau et al 2001). Following in situ hybridization and western blotting studies revealed that the signal from muscle tissue is mainly due to expression of Tnmd in tendons and ligaments as well as in the muscle sheet epimysium (Brandau et al 2001, Docheva et al 2005, Kimura et al 2008, Komiyama et al 2013, Sato et al 2014). In a temporal expression analysis in mice the presence of the Tnmd transcript was weekly detected already at embryonic day E9.5 in developing limb buds (Brandau et al 2001); however a recent paper has firmly reported very strong Tnmd mRNA expression at day E14.5 corresponding to the differentiation stage of tendon progenitors (Havis et al 2014).…”

Section: Tenomodulinmentioning

confidence: 99%

“…Watahiki et al 2008 discovered a specific expression of Tnmd in mandibular condylar cartilage at 1 week in rats. The masseter muscle is compartmentalized by a laminar structure, which was shown to express by in situ hybridization Tnmd in mouse embryos at E12.5 to E17.5 ((Sato et al 2014)). Furthermore, Oshima et al 2003 revealed Tnmd expression at E15.5 in skin and eye using Northern blotting.…”

Section: Tenomodulinmentioning

confidence: 99%

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TENOgenic MODULating INsider factor: systematic assessment on the functions of tenomodulin gene

Dex

Lin

Shukunami

et al. 2016

Gene

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Tenomodulin (TNMD, Tnmd) is a gene highly expressed in tendon known to be important for tendon maturation with key implications for the residing tendon stem/progenitor cells as well as for the regulation of endothelial cell migration in chordae tendineae cordis in the heart and in experimental tumour models. This review aims at providing an encompassing overview of this gene and its protein. In addition, its known expression pattern as well as putative signalling pathways will be described. A chronological overview of the discovered functions of this gene in tendon and other tissues and cells is provided as well as its use as a tendon and ligament lineage marker is assessed in detail and discussed. Last, information about the possible connections between TNMD genomic mutations and mRNA expression to various diseases is delivered. Taken together this review offers a solid synopsis on the up-to-date information available about TNMD and aids at directing and focusing the future research to fully uncover the roles and implications of this interesting gene.

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Section: Tenomodulinmentioning

confidence: 99%

Section: Tenomodulinmentioning

confidence: 99%

TENOgenic MODULating INsider factor: systematic assessment on the functions of tenomodulin gene

Dex

Lin

Shukunami

et al. 2016

Gene

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“…In addition, one study investigated the effects of thrombospondin2 ( Thbs2 ), an ECM protein that modulates collagen fibrillogenic and angiogenesis 46 on tendon mechanobiology. In connective tissue development, as assessed using Tnmd expression, 47 angiogenesis may potentially be involved in tissue maturation 48,49 . The tail tendon degenerated in TSP2 ‐null mice and provided an impression of increased laxity in the tail 50 .…”

Section: Discussionmentioning

confidence: 99%

“…In connective tissue development, as assessed using Tnmd expression, 47 angiogenesis may potentially be involved in tissue maturation. 48,49 The tail tendon degenerated in TSP2-null mice and provided an impression of increased laxity in the tail. 50 Although Thbs2 may be involved in tendon maturation, there is no study showing a clear relationship between Thbs2 and tendon development.…”

Section: The Expression Of Tendon Developmental-related Factors In Ch...mentioning

confidence: 99%

Exploring the role of mechanical forces on tendon development using in vivo model: A scoping review

Usami,

Iijima,

Kokubun

2023

Developmental Dynamics

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Tendons transmit the muscle contraction forces to bones and drive joint movement throughout life. While extensive research have indicated the essentiality of mechanical forces on tendon development, a comprehensive understanding of the fundamental role of mechanical forces still needs to be impaerted. This scoping review aimed to summarize the current knowledge about the role of mechanical forces during the tendon developmental phase. The electronic database search using PubMed, performed in May 2023, yielded 651 articles, of which 16 met the prespecified inclusion criteria. We summarized and divided the methods to reduce the mechanical force into three groups: loss of muscle, muscle dysfunction, and weight‐bearing regulation. In contrast, there were few studies to analyze the increased mechanical force model. Most studies suggested that mechanical force has some roles in tendon development in the embryo to postnatal phase. However, we identified species variability and methodological heterogeneity to modulate mechanical force. To establish a comprehensive understanding, methodological commonality to modulate the mechanical force is needed in this field. Additionally, summarizing chronological changes in developmental processes across animal species helps to understand the essence of developmental tendon mechanobiology. We expect that the findings summarized in the current review serve as a groundwork for future study in the fields of tendon developmantal biology and mechanobiology.

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Expression of DMP1 in the developing mouse tongue embryo

Murata

Sunohara

Sato

2015

Annals of Anatomy - Anatomischer Anzeiger

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Tenomodulin regulated the compartments of embryonic and early postnatal mouse masseter muscle

Cited by 3 publications

References 30 publications

TENOgenic MODULating INsider factor: systematic assessment on the functions of tenomodulin gene

TENOgenic MODULating INsider factor: systematic assessment on the functions of tenomodulin gene

Exploring the role of mechanical forces on tendon development using in vivo model: A scoping review

Expression of DMP1 in the developing mouse tongue embryo

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