Tenofovir diphosphate in dried blood spots and HIV-1 resistance in South Africa
Y. Singh,
J. Castillo-Mancilla,
R. Madimabe
et al.
Abstract:Background
Suboptimal antiretroviral (ART) adherence can lead to virologic failure with consequent HIV-1 resistance. Tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) is a powerful biomarker of cumulative adherence, predictive of future viremia. It has been associated with resistance in Persons With HIV (PWH) in South Africa and the US. We explored the relationship of TFV-DP concentrations with antiretroviral drug resistance at the time of treatment failure in SA.
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