Teneurin C-terminal associated peptide (TCAP)-1 modulates dendritic morphology in hippocampal neurons and decreases anxiety-like behaviors in rats

Origin of chordate peptides by horizontal protozoan gene transfer in early metazoans and protists: Evolution of the teneurin C-terminal associated peptides (TCAP)

“…Further in vivo studies strengthened the notion of a functional link between the TCAP-1 and CRF systems. TCAP-1 blocked CRF-mediated c-fos synthesis in the hippocampus and amygdala of the adult rat (Tan et al, 2009) and increased spine density in the CA1 and CA3 neurons of the rodent hippocampus but not in the amygdala (Tan et al, 2011). Moreover, TCAP-1 was shown to completely ablate CRF-induced cocaine-seeking reinstatement in rats (Kupferschmidt et al, 2011).…”

Characterization of the teneurin C-terminal associated peptide (TCAP) in the vase tunicate, Ciona intestinalis: A novel peptide system associated with energy metabolism and reproduction

“…With respect to behavior, TCAP-1 is potent at inhibiting stress-induced behaviors in vertebrates as shown in elevated-plus maze (Al Chawaf et al, 2007b;Tan et al, 2008) open-field (Tan et al, 2008), acoustic startle response (Tan et al, 2008;Wang et al, 2005) and cocaine reinstatement studies (Erb et al, in press;Kupferschmidt et al, 2010). The evidence to date suggests that this mechanism is mediated by changes in synaptic plasticity as shown by changes in axon, neurite and dendritic modifications by TCAP-1 (Al Chawaf et al, 2007a;Chand et al, 2012a,b;Tan et al, , 2011a and is supported by a clear regulation of cytoskeletal elements in vertebrates (Chand et al, 2012a,b;2013a,b) and invertebrates Kenzelmann et al, 2007;Mosca et al, 2012;Zhang et al, 2012). However, other studies suggest that this may be only part of the explanation.…”

“…However, in vertebrates, TCAP-1, is independently transcribed as a separate gene (Chand et al, 2013a,b) and is taken up by surrounding cells to regulate a number of cell-associated functions (Chand et al, 2012a,b;Ng et al, 2012). Moreover, TCAP-1 has been previously shown to be highly cell protective (Trubiani et al, 2007) and inhibits corticotropin-releasing factor (CRF)-mediated stress associated behaviors (Al Chawaf et al, 2007b;Erb et al, in press;Tan et al, 2008Tan et al, , 2011aKupferschmidt et al, 2010;Wang et al, 2005). These studies indicate a fundamental interaction between the CRF and TCAP families of peptides.…”

C-terminal processing of the teneurin proteins: Independent actions of a teneurin C-terminal associated peptide in hippocampal cells

“…However, the release of TCAP-1 may be stimulus dependent. TCAP-1 can block CRF-related stress-induced behaviors (Al Chawaf et al, 2007b;Tan et al, 2008;Wang et al, 2005), addiction behaviors (Kupferschmidt et al, 2011) and regulate corresponding morphological changes (Tan et al, 2011a) in the hippocampus. TCAP-1 may, therefore, be released under stress conditions similar to that of interleukin 1b (Rubartelli et al, 1990) and FGF-1 (Jackson et al, 1992;Shin et al, 1996).…”

“…In vitro, TCAP-1 increases cytoskeletal proteins including β-actin and β-tubulin, modulates neurite outgrowth in cultured hippocampal neurons (Al Chawaf et al, 2007a) and inhibits brain derived neurotrophic factor (BDNF) expression in hypothalamic cells (Ng et al, 2012). In vivo, synthetic TCAP-1 regulates stress-induced behavior (Al Chawaf et al, 2007b;Tan et al, 2008;Wang et al, 2005), increases spine density in the CA1 and CA3 neurons of the rodent hippocampus (Tan et al, 2011a) and blocks CRF-mediated c-fos synthesis in the hippocampus and amygdala of the adult rat (Tan et al, 2009). Furthermore, TCAP-1 ablates cocaine-seeking reinstatement in adult rats (Kupferschmidt et al, 2011).…”