Tenellic Acids A−D:  New Bioactive Diphenyl Ether Derivatives from the Aquatic Fungus Dendrospora tenella

Oh, Hyuncheol; Kwon, Tae Oh; Gloer, James B.; Marvanová, Ludmila; Shearer, Carol A.

doi:10.1021/np980496m

Cited by 42 publications

(36 citation statements)

References 16 publications

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“…[10,11], Leathesia nana [12], Phyllanthus atropurpureus [13], Symphyocladia latiuscula [14], and so on. Diphenyl ethers exhibit a wide range of interesting biological activities, such as antimicrobial [1,3,6,8,10], cytotoxic [2,6,9], radical-scavenging [11], enzyme inhibitory [5], actin inhibitory [15], anti-HSV-1 [2], and phytocidal activities [16,17]. In early chemical investigation, we reported the isolation of two diphenyl ethers, 2-isopentenyldiorcinol (9) and diorcinol (10), from a strain of endolichenic fungus Aspergillus sp.…”

Section: Introductionmentioning

confidence: 99%

Diphenyl ethers from Aspergillus sp. and their anti-Aβ42 aggregation activities

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Diphenyl ethers from Aspergillus sp. and their anti-Aβ42 aggregation activities

et al. 2014

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“…A few compounds with antibacterial properties have been obtained from aquatic hyphomycetes and their chemical structures resolved (Harrigan et al 1995, Oh et al 1999. Vining (1990) convincingly argued that production of secondary metabolites by microorganisms may be ecologically significant.…”

Section: Introductionmentioning

confidence: 99%

Interactions between stream fungi and bacteria associated with decomposing leaf litter at different levels of nutrient availability

Gulis¹,

Suberkropp²

2003

Aquat. Microb. Ecol.

140

114

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We examined the potential for interactions between aquatic hyphomycetes and bacteria isolated from leaves decaying in a headwater stream. In agar plate assays, culture filtrates of each of 28 aquatic hyphomycete isolates tested (5 species) inhibited bacterial growth (16 Gram-negative bacterial isolates belonging to 6 colony morphotypes were tested). Inhibition of bacterial growth occurred in 20% of the combinations. To determine whether such interactions could occur on decomposing leaves, Articulospora tetracladia (isolate 24-4) and bacterial isolate B2NPM3-1 (tentatively placed in Comamonadaceae) were grown in axenic and dual cultures on leaf litter in microcosms. Performance of both microorganisms was estimated by measuring leaf mass loss, fungal and bacterial biomass, conidia production, respiration and calculating carbon flow through different microbial compartments in 2 treatments that differed with respect to inorganic nutrient (N and P) concentrations. High fungal antagonistic activity demonstrated in plate assays was not corroborated in microcosms. Cumulative Articulospora tetracladia production decreased 21 to 24% in 2-membered microcosms regardless of nutrient level, whereas the bacterial isolate exhibited a differential response (1.7 times lower cumulative production in the low nutrient and 52% increase in the high nutrient treatment in 2-membered cultures compared with axenic cultures), suggesting that nutrient availability may modify microbial interactions. Fungal performance (yield coefficient and production efficiency) was not affected in 2-membered microcosms, whereas the bacterial yield coefficient was 1.7 to 2.2 times lower when grown with the fungus in comparison to axenic cultures. We observed only antagonistic or competitive interactions and no signs of synergistic relationships causing faster leaf litter decomposition or resulting in enhanced microbial production. Overall, the interactions were relatively mild and did not affect fungal dominance in the transformation of leaf organic matter.

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“…It has been reported before from aquatic fungus Dendrospora tenella. [10] The structure of 3 was identified by comparison of its spectroscopic data with those in the literature. [10] Tenellic acid C was reported to possess activity against Bacillus subtilis and Staphylococcus aureus.…”

Section: Resultsmentioning

confidence: 99%

Structure elucidation of three diphenyl ether derivatives from the mangrove endophytic fungus SBE‐14 from the South China Sea

Liu

Yang

et al. 2009

Magnetic Reson in Chemistry

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Tenellic Acids A−D: New Bioactive Diphenyl Ether Derivatives from the Aquatic Fungus Dendrospora tenella

Abstract: Tenellic acids A-D (1-4) were isolated from cultures of the freshwater fungus Dendrospora tenella. The structures of these new diphenyl ether derivatives were determined primarily by analysis of NMR data. Compounds 1-4 display antimicrobial activity against Gram-positive bacteria.

Cited by 42 publications

References 16 publications

Diphenyl ethers from Aspergillus sp. and their anti-Aβ42 aggregation activities

Diphenyl ethers from Aspergillus sp. and their anti-Aβ42 aggregation activities

Interactions between stream fungi and bacteria associated with decomposing leaf litter at different levels of nutrient availability

Structure elucidation of three diphenyl ether derivatives from the mangrove endophytic fungus SBE‐14 from the South China Sea

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