Teneligliptin protects against hypoxia/reoxygenation-induced endothelial cell injury

Zhang, Zhen; Jin, Xiang; Yang, Chun‐Feng; Li, Yumei

doi:10.1016/j.biopha.2018.10.016

Cited by 14 publications

(5 citation statements)

References 26 publications

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“…It is also shown to prevent atherosclerosis through the suppression of monocyte chemoattractant protein-1 expression, and pro-inflammatory cytokine production. In addition, TEN is also known to enhance glutathione antioxidant production within the cells [ 16 ]. Indeed, TEN is reported to possess more ·OH scavenging ability compared to the naturally occurring antioxidant glutathione and to possess direct ·OH scavenging ability [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Teneligliptin Exerts Antinociceptive Effects in Rat Model of Partial Sciatic Nerve Transection Induced Neuropathic Pain

et al. 2021

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Neuropathic pain (NP), is a chronic pain resulting from nerve injury, with limited treatment options. Teneligliptin (TEN) is a dipeptidyl peptidase-4 inhibitor (DPP-4i) approved to treat type 2 diabetes. DPP-4is prevent the degradation of the incretin hormone glucagon-like peptide 1 (GLP-1) and prolong its circulation. Apart from glycemic control, GLP-1 is known to have antinociceptive and anti-inflammatory effects. Herein, we investigated the antinociceptive properties of TEN on acute pain, and partial sciatic nerve transection (PSNT)-induced NP in Wistar rats. Seven days post PSNT, allodynia and hyperalgesia were confirmed as NP, and intrathecal (i.t) catheters were implanted and connected to an osmotic pump for the vehicle (1 μL/h) or TEN (5 μg/1 μL/h) or TEN (5 μg) + GLP-1R antagonist Exendin-3 (9–39) amide (EXE) 0.1 μg/1 μL/h infusion. The tail-flick response, mechanical allodynia, and thermal hyperalgesia were measured for 7 more days. On day 14, the dorsal horn was harvested and used for Western blotting and immunofluorescence assays. The results showed that TEN had mild antinociceptive effects against acute pain but remarkable analgesic effects against NP. Furthermore, co-infusion of GLP-1R antagonist EXE with TEN partially reversed allodynia but not tail-flick latency. Immunofluorescence examination of the spinal cord revealed that TEN decreased the immunoreactivity of glial fibrillary acidic protein (GFAP). Taken together, our findings suggest that TEN is efficient in attenuation of PSNT-induced NP. Hence, the pleiotropic effects of TEN open a new avenue for NP management.

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Section: Introductionmentioning

confidence: 99%

Teneligliptin Exerts Antinociceptive Effects in Rat Model of Partial Sciatic Nerve Transection Induced Neuropathic Pain

et al. 2021

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“…In disease conditions, LDH activity is elevated and contributes towards the progression of DR from stage 1 to stage 4 [58]. Experimentally, an inhibitor of LDH release, i.e., teneligliptin, protected the retinal endothelial cell from injury against the hypoxia/reoxygenation events [59]. In the present study, the results revealed that AST has the potential to reduce the LDH level and raise the catalase level in retinal tissue against the STZ toxicity on mice retina and delay the progression of DR.…”

Section: Discussionmentioning

confidence: 99%

Astaxanthin Ameliorates Diabetic Retinopathy in Swiss Albino Mice via Inhibitory Processes of Neuron-Specific Enolase Activity

Subramanian

Thirunavukkarasu²,

Muthuraman³

2022

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Retinopathy is one of the most common complications of diabetes mellitus. Diabetic retinopathy (DR) occurs due to microvascular damage in retinal tissues provoked by high blood sugar levels. The available drugs for DR are limited. Astaxanthin (AST) has anti-hypertensive, anti-obesity, and anti-diabetic properties. However, the therapeutic effect of AST on DR remains elusive. The present study is designed to investigate the effects of AST on DR via inhibition of neuron-specific enolase (NSE) activity. DR was induced by the administration of streptozotocin (STZ, 35 mg/kg: intraperitoneal; and 20 μL of STZ: intravitreal) in mice. AST (10 and 20 mg/kg) was administered orally (p.o.) for 21 days. The DR associated visual changes were assessed at different time intervals via optokinetic motor response (OMR) and penta-maze (PM) tests. Blood glucose level as well as retinal catalase, lactate dehydrogenase (LDH), & neuron-specific enolase (NSE) were estimated. The reference drug i.e., dexamethasone (DEX, 10 mg/kg; p.o.) was administered for 21 days. The administration of AST showed significant ameliorative potential in DR. Hence, AST can be used as a natural medicine for the management of DR due to its potential antioxidant, anti-diabetic, and NSE inhibitory properties.

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“…A recent study found that teneligliptin could rescue endothelial cell viability in rat cardiac microvascular endothelial cells exposed to hypoxia/reoxygenation injury. 26 While there is considerable evidence that DPP-4 inhibition can improve endothelial cell viability and function after ischemia/reperfusion, the role of teneligliptin in protecting brain endothelial cells from OGD/R-induced injury is not clear. 27 Our experiments demonstrate that teneligliptin significantly rescued this OGD/R-induced decreased cell viability in a dose-dependent manner, and remarkably, the higher dose almost completely restored cell viability.…”

Section: Discussionmentioning

confidence: 99%

Teneligliptin protects against ischemia/reperfusion-induced endothelial permeabilityin vivoandin vitro

et al. 2020

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Teneligliptin protects against hypoxia/reoxygenation-induced endothelial cell injury

Cited by 14 publications

References 26 publications

Teneligliptin Exerts Antinociceptive Effects in Rat Model of Partial Sciatic Nerve Transection Induced Neuropathic Pain

Teneligliptin Exerts Antinociceptive Effects in Rat Model of Partial Sciatic Nerve Transection Induced Neuropathic Pain

Astaxanthin Ameliorates Diabetic Retinopathy in Swiss Albino Mice via Inhibitory Processes of Neuron-Specific Enolase Activity

Teneligliptin protects against ischemia/reperfusion-induced endothelial permeabilityin vivoandin vitro

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