Tendons and Ligaments: Connecting Developmental Biology to Musculoskeletal Disease Pathogenesis

Asahara, Hiroshi; Inui, Masafumi; Lotz, Martin

doi:10.1002/jbmr.3199

Cited by 69 publications

(54 citation statements)

References 90 publications

(226 reference statements)

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“…With advancing age, a progression in collagen maturation in tendons and ligaments leads to an increase in the number of cross- links and a decrease in the collagen turnover rate [1]. As a result, collagen fibers become less compliant, and tendons and ligaments become less elastic [13].…”

Section: Discussionmentioning

confidence: 99%

“…As a result, collagen fibers become less compliant, and tendons and ligaments become less elastic [13]. Additionally, there are noticeable changes in skeletal muscles, including sarcopenia, lower force production, reduced flexibility, and increased collagen content [1]. The combined or synergistic effects of these changes in muscle and connective tissue are thought to contribute to the age-related increases in orthopaedic injuries [9,11].…”

Section: Discussionmentioning

confidence: 99%

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Role of Cross-training in Orthopaedic Injuries and Healthcare Burden in Masters Swimmers

2018

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We determined whether the incidence of injuries would increase with advancing age and whether the participation in cross-training would be related to a decreased rate of injuries and healthcare costs in Masters swimmers. A total of 499 swimmers (55±14 years of age) belonging to US Masters Swimming completed a comprehensive questionnaire that included questions regarding their medical history as well as their training history. In average, swimmers had been training for 13±12 years, and 35, 40, and 47% participated in running, cycling, and dryland resistance training, respectively. According to the logistic regression, prevalence of injuries increased significantly but modestly with advancing age (p<0.05). Linear regression analysis showed that for every 1 month increase in the length of injury, healthcare costs increased by 7.4% (p<0.05). Linear regression and logistic regression analyses determined that overall volume of swimming training was not related to age or incidence of injuries, respectively. Multinomial logistic regression analyses using age and sex as predictors demonstrated that the odds of reporting a swim-related injury were significantly lower for individuals who participated in any number of cross-training activities compared with those who do not cross-train (p<0.05). Regular participation in any cross-training modality was inversely related to age (p<0.05). We concluded that the diversification of the overall training program by incorporating cross-training may be an important strategy to reduce sport-specific injuries among Masters athletes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Role of Cross-training in Orthopaedic Injuries and Healthcare Burden in Masters Swimmers

2018

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“…Ligaments connect bone to bone and tendons connect muscle to bone, together uniting all musculoskeletal elements into an all‐in‐one system. They are closely related tissues that are made of tenocytes with similar gene expression profile . However, genetic deletion of certain key transcription factors critical for ligament and tendon development led to completely different phenotypes in these two structures, indicating that they might employ different developmental mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Cruciate ligament, patellar tendon, and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds

Zhang

Kameneva

Annusver

et al. 2020

Developmental Dynamics

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Background: Cruciate ligament (CL) and patellar tendon (PT) are important elements of the knee joint, uniting femur, patella, and tibia into a single functional unit. So far, knowledge on the developmental mechanism of CL, PT, and patella falls far behind other skeletal tissues.Results: Here, employing various lineage tracing strategies we investigate the cellular sources and dynamics that drive CL, PT, and patella formation during mouse embryonic development. We show that Gdf5 and Gli1 are generally expressed in the same cell population that only contributes to CL, but not PT or patella development. In addition, Col2 is expressed in two independent cell populations before and after joint cavitation, where the former contributes to the CL and the dorsal part of the PT and the latter contributes to the patella.Moreover, Prrx1 is always expressed in CL and PT progenitors, but not patella progenitors where it is switched off after joint cavitation. Finally, we reveal that patella development employs different cellular dynamics before and after joint cavitation.Conclusions: Our findings delineate the expression changes of several skeletogenesis-related genes before and after joint cavitation, and provide an indication on the cellular dynamics underlying ligament, tendon, and sesamoid bone formation during embryogenesis. K E Y W O R D S cellular dynamics, cruciate ligament, embryonic development, lineage tracing, patella, patellar tendon

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“…The anterior cruciate ligament (ACL), connecting the femur and tibia, is a key structure of the knee joint [1] . Injury to the ACL is a major clinical problem for athletes due to the limited self-repair capacity of the ACL.…”

Section: Introductionmentioning

confidence: 99%

Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage

Ogata

Mabuchi

Shinoda

et al. 2018

Regenerative Therapy

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IntroductionThe anterior cruciate ligament (ACL) consists of various components, such as collagen, elastin fibres, and fibroblasts. Because ACL has a poor regenerative ability, ACL reconstruction need require the use of autologous tendons. In recent years, tissue-resident stem cells have been studied to promote ACL regeneration as an alternatively method. However, the existence of stem cells in ligaments has not been clearly defined. Here, we prospectively isolated stem cells from ACLs and characterized their properties.MethodsACLs from 11 donors and bone marrows (BM) from 8 donors were obtained with total knee arthroplasty. We used flow cytometry to screen the cell surface markers on ACL cells. Frozen sections were prepared from patient ACL tissues and stained with specific antibodies. Cultured ACL-derived and BM-derived cells at passage 3 were differentiated into adipocytes, osteoblasts and tendon/ligament cells.ResultsACL-derived mesenchymal stem/stromal cells (ACL-MSCs) expressed high levels of CD73 and CD90. Immunohistochemical analyses revealed that ACL-MSCs were located on the inner surface of ACL sinusoids. Furthermore, the expression of cell surface antigens was clearly different between ACL-MSCs and bone marrow (BM)-derived MSCs (BM-MSCs) at the time of isolation, but the two cell populations became indistinguishable after long-term culture. Interestingly, ACL-MSCs are markedly different from BM-MSCs in their differentiation ability and have a high propensity to differentiate into ligament-committed cells.ConclusionsOur findings suggest that ACL-MSCs express CD90 and CD73 markers, and their differentiation capacity is maintained even through culture. The cell population having tissue-specific properties is an important research target for investigating the ligament therapies.

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Tendons and Ligaments: Connecting Developmental Biology to Musculoskeletal Disease Pathogenesis

Cited by 69 publications

References 90 publications

Role of Cross-training in Orthopaedic Injuries and Healthcare Burden in Masters Swimmers

Role of Cross-training in Orthopaedic Injuries and Healthcare Burden in Masters Swimmers

Cruciate ligament, patellar tendon, and patella formation involves differential cellular sources and dynamics as joint cavitation proceeds

Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage

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