Tendon xanthomas

Rekha, Arcot; Krishna, Deepak

doi:10.1016/j.foot.2010.04.004

Cited by 5 publications

(7 citation statements)

References 7 publications

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“…En cuanto al tratamiento de los xantomas, se basa en la reducción de la concentración de lípidos del suero con fármacos que produzcan la regresión de los xantomas. En el caso de los xantomas tendinosos, pueden tardar años en resolverse y el objetivo de reducir los niveles de lípidos es reducir el riesgo de enfermedad cardiovascular ateroesclerótica y pancreatitis, la excisión quirúrgica está indicada en xantomas tendinosos grandes que restringen el movimiento de las articulaciones o cuando hay duda diagnóstica (15) . En el caso del paciente, debido a que el colesterol estaba dentro de los rangos normales, no requirió tratamiento médico.…”

Section: Discussionunclassified

Xantoma tendinoso normolipémico múltiple en coexistencia con glaucoma terminal bilateral y sindactilia

et al. 2021

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Los xantomas tendinosos están habitualmente asociados con hiperlipidemia, de ahí que son infrecuentes los xantomas tendinosos normolipémicos. La histopatología de este cuadro es característica por la presencia de células espumosas, hendiduras de colesterol y células de Touton. Presentamos el caso de un paciente varón de 22 años portador de xantomas tendinosos normolipémicos, en coexistencia con glaucoma terminal bilateral y sindactilia donde la histología y la inmunohistoquímica fueron de gran utilidad para el diagnóstico definitivo.

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Section: Discussionunclassified

Xantoma tendinoso normolipémico múltiple en coexistencia con glaucoma terminal bilateral y sindactilia

et al. 2021

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“…Singapore, the smallest nation within Western Pacific region with a total population of only 5.9 million people, is uniquely diverse with different ethnics, but has only reported 50 patients with molecularly confirmed LDLR mutations 20) by nextgeneration sequencing method. Thailand and the Philippines have also respectively reported 45 and 20 molecularly confirmed FH patients using PCR and denaturing high-performance liquid chromatography methods to detect LDLR mutations, but their tendons at Achilles tendons, dorsal extensor of hands, elbows or knees 31) . Premature corneal arcus was visually identified by the presence of white opaque ring at the peripheral of cornea 32) in participants with age ＜45 years old, while participants with corneal arcus but age ≧45 years old were asked for the age of onset for the corneal arcus.…”

Section: Definition Of Termsmentioning

confidence: 99%

Familial Hypercholesterolaemia in the Malaysian Community: Prevalence, Under-Detection and Under-Treatment

Chua

Razman

Ramli

et al. 2021

JAT

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Aim: Familial hypercholesterolaemia (FH) is the most common autosomal dominant lipid disorder, leading to severe hypercholesterolaemia. Early detection and treatment with lipid-lowering medications may reduce the risk of premature coronary artery disease in FH patients. However, there is scarcity of data on FH prevalence, detection rate, treatment and control with lipid-lowering therapy in the Malaysian community. Methods: Community participants ( n =5130) were recruited from all states in Malaysia. Blood samples were collected for lipid profiles and glucose analyses. Personal and family medical histories were collected by means of assisted questionnaire. Physical examination for tendon xanthomata and premature corneal arcus were conducted on-site. FH were clinically screened using Dutch Lipid Clinic Network Criteria. Results: Out of 5130 recruited community participants, 55 patients were clinically categorised as potential (Definite and Probable) FH, making the prevalence FH among the community as 1:100. Based on current total population of Malaysia (32 million), the estimated number of FH patients in Malaysia is 320,000, while the detection rates are estimated as 0.5%. Lipid-lowering medications were prescribed to 54.5% and 30.5% of potential and possible FH patients, respectively, but none of them achieved the therapeutic LDL-c target. Conclusion: Clinically diagnosed FH prevalence in Malaysian population is much higher than most of the populations in the world. At community level, FH patients are clinically under-detected, with majority of them not achieving target LDL-c level for high-risk patients. Therefore, public health measures are warranted for early detection and treatment, to enhance opportunities for premature CAD prevention.

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“…In addition to the Achilles tendons, the other tendons where xanthomas usually appear are the tendons of the hand (extensor tendons) and the elbow [ 5 ]. Xanthomas have also been reported in the plantar fascia, fascia and periosteum overlying the lower tibia, the peroneal tendons, the triceps tendon and the patellar tendon [ 6 ]. Mechanical stress and neovascularization are considered as predisposing factor for xanthomas growth [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Mechanical stress and neovascularization are considered as predisposing factor for xanthomas growth [ 7 ]. In addition to tendinous xanthomas, several types of xanthomas can be found such as tuberous and eruptive xanthoma, eyelid xanthelasma and xanthoma planum [ 6 ]. Xanthomas are frequently associated with hyperlipidemia, and high levels of triglycerides and total cholesterol: within families affected by familial hypercholesterolemia and type II hyperlipoproteinemia Achilles tendon xanthomas are frequent, probably because of the low-density lipoprotein storage in the tendon [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Minimally invasive excision and reconstruction of Achilles tendon xanthoma using free autologous semitendinosus tendon transfer: a surgical technique

et al. 2023

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Background Tendon xanthomatosis is often associated with familial hypercholesterolemia, but it can also occur in other medical conditions. The Achilles tendon is the most common site of tendon xanthomas. Reconstruction of large defects after the xanthoma excision, can be challenging. Methods We propose a novel technique for Achilles tendon reconstruction with the use of an ipsilateral autologous semitendinosus tendon graft. The technique consists of six steps. Results This procedure has a low rate of complications and provides results that are at least comparable with those reported with other surgical approaches.

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Tendon xanthomas

Abstract: Tendon xanthomas usually present over the tendo Achilles and are associated with hyperlipidaemias. A brief review of xanthomas is presented.

Cited by 5 publications

References 7 publications

Xantoma tendinoso normolipémico múltiple en coexistencia con glaucoma terminal bilateral y sindactilia

Xantoma tendinoso normolipémico múltiple en coexistencia con glaucoma terminal bilateral y sindactilia

Familial Hypercholesterolaemia in the Malaysian Community: Prevalence, Under-Detection and Under-Treatment

Minimally invasive excision and reconstruction of Achilles tendon xanthoma using free autologous semitendinosus tendon transfer: a surgical technique

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