Tendon to bone healing and its implications for surgery

Bunker, Daniel Lee John; Illie, V.; Nicklin, S.

doi:10.32098/mltj.03.2014.13

Cited by 44 publications

(28 citation statements)

References 88 publications

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“…Furthermore, tendon-to-bone healing involves a third category, which relies on a combined healing model including both bone and soft tissue. 5 NSAIDs were not shown to affect soft tissue healing but did have a detrimental effect on tendon-to-bone healing in animal models. 6 NSAIDs have a direct effect on the mediators involved in tendon healing.…”

Section: Discussionmentioning

confidence: 86%

Effects of Perioperative Nonsteroidal Anti-inflammatory Drug Administration on Soft Tissue Healing: A Systematic Review of Clinical Outcomes After Sports Medicine Orthopaedic Surgery Procedures

Constantinescu

Campbell

Moatshe

et al. 2019

Orthopaedic Journal of Sports Medicine

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Background: The effects of perioperative nonsteroidal anti-inflammatory drugs (NSAIDs) on soft tissue healing in humans have yet to be established. Purpose: To systematically review the literature addressing the effects of perioperative NSAID administration on soft tissue healing and clinical patient outcomes. Study Design: Systematic review; Level of evidence, 3. Methods: This review study was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. A review of the literature regarding the existing evidence for clinical effects of NSAID use on soft tissue healing was performed through use of the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials, PubMed (1980 to present), and MEDLINE. Inclusion criteria for articles were as follows: outcome studies after soft tissue (ligament, meniscus, tendon, muscle) healing after surgical procedure with perioperative NSAID administration, at least 1 year of follow-up, English language, and human participants. Results: A total of 466 studies were initially retrieved, with 4 studies satisfying all inclusion criteria. Among the surgical procedures reported, 93% of the patients (4144/4451) underwent anterior cruciate ligament (ACL) reconstruction, 3% (120/4451) underwent rotator cuff repair, 3% (155/4451) underwent Bankart shoulder repair, and 1% (32/4451) underwent meniscal repair. The reported surgical failure rate among patients administered NSAIDs was 3.6% (157/4360). The reported surgical failure rate among control participants not given NSAIDs was 3.7% (147/3996). NSAID use showed no statistically significant effect on need for reoperation in meniscal repair ( P = .99), ACL reconstruction ( P = .8), and Bankart repair ( P = .8) compared with no NSAID administration. Celecoxib administration had a significantly higher rate of retear (37%) after rotator cuff repair compared with ibuprofen (7%) ( P = .009). Conclusion: Insufficient data are available to definitively state the effects of perioperative NSAIDs on soft tissue healing. Use of NSAIDs should be considered on a case-by-case basis and may not affect healing rates following either meniscal, ACL, rotator cuff, or Bankart repair. However, celecoxib (a selective COX-2 inhibitor) may inhibit tendon-to-bone healing in rotator cuff repair. Further research through clinical trials is required to fully determine whether NSAIDs have an adverse effect on soft tissue healing.

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Section: Discussionmentioning

confidence: 86%

Effects of Perioperative Nonsteroidal Anti-inflammatory Drug Administration on Soft Tissue Healing: A Systematic Review of Clinical Outcomes After Sports Medicine Orthopaedic Surgery Procedures

Constantinescu

Campbell

Moatshe

et al. 2019

Orthopaedic Journal of Sports Medicine

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“…Because neovascularization rarely occurs from the tuberosity bone into the reattached tendon, the nutrients and healing factors are provided to the repair site in an antegrade fashion via epitendinous blood vessels and diffusion into the synovial fluid through the circulus articuli vasculosis around the joint capsule. 2 These healing factors foster chemotaxis of fibroblasts and the proliferation of a collagen and extracellular matrix around the repair site. 21 Oguma et al showed that this collagen is then anchored to the repair interface via the formation of woven bone.…”

Section: Discussionmentioning

confidence: 99%

“… 13 , 14 An established bone tunnel suture fixation method of the supraspinatus was used. 2 , 14 The surgeon was blinded to group designation at the time of surgery. Daily gavages continued until sacrifice date.…”

Section: Methodsmentioning

confidence: 99%

Caffeine intake does not appear to impair tendon-to-bone healing strength in a rat rotator cuff repair model

Young¹,

Sheppard²,

Phillips³

et al. 2022

JSES International

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“…There have been no studies investigating whether remnant tissue is pathological or physiological tissue that can be preserved. 23,24 The limitations of this study include the modest number of articles due to the narrow inclusion criteria, which may limit generalization to the wider population. The outcome-measurement tools were heterogeneously reported, preventing direct comparison of outcomes and undermining the need for standardized methods.…”

Section: Discussionmentioning

confidence: 99%

“…There have been no studies investigating whether remnant tissue is pathological or physiological tissue that can be preserved. 23 , 24 …”

Section: Discussionmentioning

confidence: 99%

High-Grade Bursal Side Rotator-Cuff Repair: A Surgical Outcome Review

Prasetia¹,

Kholinne²,

Suvarly³

et al. 2021

ORR

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Purpose:We aimed to evaluate surgical outcomes of high-grade bursal rotator cuff-tear repairs. Methods: This systematic review was performed in May 2020 in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using PubMed. Inclusion criteria were English-language studies reporting the results of pain improvement, functional outcome scores, and radiographic examinations after repair of bursal side partial rotator-cuff tears at any time point in patients of any age and with all levels of evidence. Exclusion criteria were articles not in English, in vitro or animal studies, epidemiological studies, and such article types as technical notes or narrative reviews. Results: Of 58 articles, five were included in this study, of which three and two had level III and IV evidence, respectively, four were comparative studies, and one was a case series. Visual analogue scales were used in four of the five studies, all showing improvement in pain assessment from 5.87 preoperatively to 1.02 postoperatively. All five studies showed significant improvement on each functional outcome score at the final follow-up. The retear rate for all studies was 10.97% (27 of 246). Conclusion: High-grade bursal side partial-thickness rotator cuff-tear repair gave satisfactory results in terms of pain scores, range of motion, and functional outcomes. The retear rate was still considerably high (10.9%), necessitating better understanding of the basic science, such as molecular mechanisms during adaptation, to improve the surgical technique.

show abstract

Tendon to bone healing and its implications for surgery

Cited by 44 publications

References 88 publications

Effects of Perioperative Nonsteroidal Anti-inflammatory Drug Administration on Soft Tissue Healing: A Systematic Review of Clinical Outcomes After Sports Medicine Orthopaedic Surgery Procedures

Effects of Perioperative Nonsteroidal Anti-inflammatory Drug Administration on Soft Tissue Healing: A Systematic Review of Clinical Outcomes After Sports Medicine Orthopaedic Surgery Procedures

Caffeine intake does not appear to impair tendon-to-bone healing strength in a rat rotator cuff repair model

High-Grade Bursal Side Rotator-Cuff Repair: A Surgical Outcome Review

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