Tendon regeneration: an anatomical and histological study in sheep

Turhan, Ahmet Uğur; Kerimoğlu, Servet; Doğru, Ali; Aydin, Hafız; Yuluğ, Esin

doi:10.1007/s00167-004-0506-8

Cited by 8 publications

(8 citation statements)

References 25 publications

(26 reference statements)

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“…The study revealed that equal tension in the regenerated ST tendons and adjacent G tendons, when performing a voluntarily hamstring contraction, indicated a functional muscle tendon complex with good mechanical properties. The result rate of 72 % of the ST tendon regeneration revealed regenerated tendon tissue with a normal histological appearance, similar to the control tendon, and the knee evaluation form results showed minimal hamstring strength deficit of the harvested tendon, in agreement with previous studies [7,15,16].…”

Section: Discussionsupporting

confidence: 89%

“…Both in vitro and in vivo studies have illustrated "intrinsic" and "extrinsic" healing potential of the injured or surgically reconstructed tendon, although some have shown a regenerative process of the full-length tendon [13][14][15]. One research investigated the arterial supply of the pes anserinus tendons at the tibial attachment, but not the whole length of the tendons [16].…”

Section: Introductionmentioning

confidence: 99%

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Semitendinosus tendon regeneration after anterior cruciate ligament reconstruction: can we use it twice?

Stevanovic

Blagojević

Petković

et al. 2013

International Orthopaedics (SICOT)

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Purpose It has been demonstrated that the semitendinosus tendon can regenerate after being harvested in its whole length and thickness for anterior cruciate ligament (ACL) reconstruction. Ultrasound studies and guided biopsies of the regenerated tendon have shown compatibility and resembling features of the normal tendon. The question is if this neo-tendon is biologically and functionally adequate for re-use? Methods Two randomised groups of 150 volunteers were followed up for two years after harvesting the semitendinosus only (25) or the semitendinosus and gracilis tendons (25) in ACL reconstruction. The patients were followed up with clinical and ultrasound examinations, biopsies and histological tests. Surgical exploration was done in three patients for macroscopic verification. The injected arteries of four lower limbs were dissected and the tendon's arterial supplies were examined. Results Seventy-two percent of the cases showed regeneration of the semitendinosus tendons. The neotendons were inserted mostly below the knee joint (83.3 %) where they had fused with the gracilis tendon, and above the joint (60 %) when the gracilis was harvested as well. The isokinetic strength of the hamstrings and quadriceps was not significantly diminished on the operated side. A macroscopic and histological analysis of the regenerated tendons demonstrates close resemblance to normal anatomy, with focal areas of fibrosis. In one patient the regenerated tendon was used for medial patellofemoral ligament reconstruction. Conclusion The semitendinosus muscle can recover and the tendon has great potential to regenerate after harvesting for ACL reconstruction. Our data suggest that the regenerated tendons could be used for iterative ligament reconstruction.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Semitendinosus tendon regeneration after anterior cruciate ligament reconstruction: can we use it twice?

Stevanovic

Blagojević

Petković

et al. 2013

International Orthopaedics (SICOT)

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“…Furthermore, the studies of Papandrea et al [13] and especially of Rispoli et al [15] confirmed the previous findings. Nevertheless, in a recent study of sheeps, Turhan et al [25] have found that the harvested tendons of musculus extensor digitalis lateralis regenerated in all cases but the regeneration occurred proximally and distally at the same time, thus raising questions about the direction of the regeneration process.…”

Section: Discussionmentioning

confidence: 99%

Hamstring tendons regeneration after ACL reconstruction: an overview

Nikolaou

Efstathopoulos

Wredmark

2006

Knee Surg Sports Traumatol Arthrosc

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Despite the long lasting research the ideal method of reconstructing the ACL has not been found so far. The last year's attention has shifted to the use of the multistrand hamstring tendon grafts. High ultimate tensile load, multiple-bundle replacement that better approximates the anatomy of the normal ACL and low donor site morbidity are the main advantages of this ACL replacement graft. These theoretical advantages have been multiplied when surprisingly studies have shown that semitendinosus and gracilis tendons actually regenerate after harvesting for use as ACL autografts. In this review article we summarize the current knowledge concerning the hamstring regeneration and we focus on issues that have clinical relevance or issues that have not been answered so far.

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“…Besides, the mature collagen fiber has a typical periodic banding pattern (64–70 nm) (Doherty, 2007). Thus, a tendon is recognizable by the organization of its fibers: regularly arranged, wavy appearing collagen bundles and fibrocyte nuclei (Turhan et al, 2004). According to our data, this organization is reached only in juvenile specimens of L. latinasus.…”

Section: Discussionmentioning

confidence: 99%

Sesamoids in Anurans: New Data, Old Issues

Ponssa

Goldberg

Abdala

2010

The Anatomical Record

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Sesamoids are skeletal elements rarely considered in studies of the vertebrate skeleton. In this work, we integrate ontogenetic data of anuran sesamoids in two species (Leptodactylus latinasus and Pleurodema cf. guayapae), the related structures (tendons, muscles, and joints) in L. latinasus, and a survey of sesamoid distribution in 185 anuran taxa. Our main goals are: (1) to contribute to the knowledge of the comparative anatomy of sesamoids in tetrapods; (2) to provide additional developmental evidence to interpret the ontogenetic pattern of sesamoids in anurans, as a key to elucidate that of tetrapods in general; (3) to provide data about tendon development in relation to sesamoid development in anurans for the first time; and (4) to propose a pattern of anuran sesamoid distribution. The homologies of sesamoids across tetrapods are discussed here. Observations were made in cleared and stained skeletal whole-mounts. Fifty-four sesamoids were found in anurans, thirty-seven of which occur in L. latinasus. The traditional point of view of embedded sesamoids always resulting from biomechanical stimuli of a previously existing tendon is not sustained by our data. Many sesamoids arise before the differentiation of a tendinous tissue. Our survey results in a data set where the two big anuran clades, Hyloides (12 families) and Ranoides (14 families), were represented. The matrix has 38% missing entries. Most of the surveyed sesamoids have multiple origins, with only three of them (about 19%) having one origin. Anat Rec, 293:1646Rec, 293: -1668

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Tendon regeneration: an anatomical and histological study in sheep

Cited by 8 publications

References 25 publications

Semitendinosus tendon regeneration after anterior cruciate ligament reconstruction: can we use it twice?

Semitendinosus tendon regeneration after anterior cruciate ligament reconstruction: can we use it twice?

Hamstring tendons regeneration after ACL reconstruction: an overview

Sesamoids in Anurans: New Data, Old Issues

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