Tendon-Derived Stem Cells for Rotator Cuff Repair

Randelli, Pietro; Cucchi, Davide; Cabitza, Federico; Compagnoni, Roberto; Menon, Alessandra

doi:10.1053/j.oto.2016.06.004

Cited by 4 publications

(4 citation statements)

References 62 publications

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“…Nevertheless, the amount of available material for MSC extraction from shoulder periarticular tissues is limited and requires expansion in a dedicated facility before clinical use, which can be limited by regulatory restrictions concerning the advanced therapy medicinal products and the high costs of good manufacturing practice cell expansion. 14,35 As a result, studies using tendon-derived MSCs remain limited to animal models, 31 while clinical research has shifted focus to other sources of MSCs.…”

Section: History and Evolution Of Rotator Cuff Surgery Including Biol...mentioning

confidence: 99%

Arthroscopic Rotator Cuff Repair Augmentation With Autologous Microfragmented Lipoaspirate Tissue Is Safe and Effectively Improves Short-term Clinical and Functional Results: A Prospective Randomized Controlled Trial With 24-Month Follow-up

et al. 2022

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Background: Autologous microfragmented lipoaspirate tissue has been recently introduced in orthopaedics as an easily available source of nonexpanded adipose-derived mesenchymal stem cells. Autologous microfragmented lipoaspirate tissue is expected to create a suitable microenvironment for tendon repair and regeneration. Rotator cuff tears show a high incidence of rerupture and represent an ideal target for nonexpanded mesenchymal stem cells. Purpose: To evaluate the safety and efficacy of autologous lipoaspirate tissue in arthroscopic rotator cuff repair. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: Consecutive patients referring to the investigation center for surgical treatment of magnetic resonance imaging–confirmed degenerative posterosuperior rotator cuff tears were assessed for eligibility. Those who were included were randomized to receive a single-row arthroscopic rotator cuff repair, followed by intraoperative injection of autologous microfragmented adipose tissue processed with an enzyme-free technology (treatment group) or not (control group). Clinical follow-up was conducted at 3, 6, 12, 18, and 24 months; at 18 months after surgery, magnetic resonance imaging of the operated shoulder was obtained to assess tendon integrity and rerupture rate. Results: An overall 177 patients were screened, and 44 (22 per group) completed the 24-month follow-up. A statistically significant difference in favor of the treatment group in terms of Constant-Murley score emerged at the primary endpoint at 6-month follow-up (mean ± SD; control group, 76.66 ± 10.77 points; treatment group, 82.78 ± 7.00 points; P = .0050). No significant differences in clinical outcome measures were encountered at any of the other follow-up points. No significant differences emerged between the groups in terms of rerupture rate, complication rate, and number of adverse events. Conclusion: This prospective randomized controlled trial demonstrated that the intraoperative injection of autologous microfragmented adipose tissue is safe and effective in improving short-term clinical and functional results after single-row arthroscopic rotator cuff repair. Registration: NCT02783352 (ClinicalTrials.gov identifier).

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Section: History and Evolution Of Rotator Cuff Surgery Including Biol...mentioning

confidence: 99%

Arthroscopic Rotator Cuff Repair Augmentation With Autologous Microfragmented Lipoaspirate Tissue Is Safe and Effectively Improves Short-term Clinical and Functional Results: A Prospective Randomized Controlled Trial With 24-Month Follow-up

et al. 2022

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“…Although in vivo animal studies showed some promising approaches to enhance tendon-to-bone healing. 43…”

Section: Stem Cellsmentioning

confidence: 99%

“…The current literature regarding the isolation, characterization, and therapeutic use of TDSCs in shoulder surgery is limited but encouraging. Although in vivo animal studies showed some promising approaches to enhance tendon-to-bone healing 43 …”

Section: Regenerative Medicinementioning

confidence: 99%

Regenerative Medicine Solutions for Rotator Cuff Injuries in Athletes: Indications and Outcomes

Foti,

Vellucci,

Santoro

2024

Sports Medicine and Arthroscopy Review

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Rotator cuff (RC) injuries include a wide range of pathologic states. Athletes are perhaps the most susceptible to RC injuries ranging from tendinopathy to partial or full-thickness tears, due to functional overload and repetitive movements, causing abstention from sports for long periods. Regenerative medicine keeps giving us multiple choices to fight the disability caused by these pathologies. A literature search was performed, and findings related to the structure-function of rotator cuff units, pathophysiology of injuries, regenerative medicine treatments, and future strategies were outlined. Platelet-rich plasma (PRP) has a greater number of articles and clinical trials, accompanied by stem cells progenitor, prolotherapy, and new approaches such as microfragmented adipose tissue and exosomes. RC injuries in athletes can cause pain, functional impotence, and the risk of recurrence, and can lead them to stop playing sports. Regenerative medicine offers a range of treatments, but some of them need further studies to underline their actual validity.

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“…Finally, mesenchymal stem/stromal cells (MSCs) gained popularity in regenerative medicine for their potential to enhance tissue healing. MSCs are believed to enhance tissue healing through the stimulation of local cells via the paracrine mechanism and anti-inflammatory and/or immunomodulatory activity, thus creating a suitable microenvironment for tissue repair and regeneration [7][8][9][10][11][12][13][14][15]. In recent years, the adipose tissue and its stromal vascular fraction (SVF) have been demonstrated to provide an easily accessible source for these cells and modulatory substances, with promising results in preclinical models [1].…”

Section: Introductionmentioning

confidence: 99%

A Worldwide Analysis of Adipose-Derived Stem Cells and Stromal Vascular Fraction in Orthopedics: Current Evidence and Applications

Ossendorff

Menon

Schildberg

et al. 2023

JCM

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The biological enhancement of tissue regeneration and healing is an appealing perspective in orthopedics. We aimed to conduct a systematic review to describe the global distribution of studies investigating the use of adipose tissue derivates in orthopedics and to provide information on their quality and on the products available. The quality of the included studies was assessed using the modified Coleman Methodology Score (mCMS) and the Cochrane risk-of-bias tool for randomized trials. Eighty-two studies were included, with a total of 3594 patients treated. In total, 70% of the studies investigated the treatment of knee disorders, predominantly osteoarthritis; 26% of all studies dealt with expanded adipose-derived stem/stromal cells (ADSCs), 72% of which had stromal vascular fraction (SVF); 70% described the injection of adipose tissue derivates into the affected site; and 24% described arthroscopies with the addition of adipose tissue derivates. The mean mCMS for all studies was 51.7 ± 21.4 points, with a significantly higher score for the studies dealing with expanded ADSCs compared to those dealing with SVF (p = 0.0027). Our analysis shows high heterogeneity in terms of the types of performed procedures as well as the choice and processing of adipose tissue derivates.

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Tendon-Derived Stem Cells for Rotator Cuff Repair

Cited by 4 publications

References 62 publications

Arthroscopic Rotator Cuff Repair Augmentation With Autologous Microfragmented Lipoaspirate Tissue Is Safe and Effectively Improves Short-term Clinical and Functional Results: A Prospective Randomized Controlled Trial With 24-Month Follow-up

Arthroscopic Rotator Cuff Repair Augmentation With Autologous Microfragmented Lipoaspirate Tissue Is Safe and Effectively Improves Short-term Clinical and Functional Results: A Prospective Randomized Controlled Trial With 24-Month Follow-up

Regenerative Medicine Solutions for Rotator Cuff Injuries in Athletes: Indications and Outcomes

A Worldwide Analysis of Adipose-Derived Stem Cells and Stromal Vascular Fraction in Orthopedics: Current Evidence and Applications

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