Tendinopathy

Millar, Neal L.; Silbernagel, Karin G.; Thorborg, Kristian; Kirwan, Paul; Galatz, Leesa M.; Abrams, Geoffrey D.; Murrell, George A. C.; McInnes, Iain B.; Rodeo, Scott A.

doi:10.1038/s41572-020-00234-1

Cited by 379 publications

(360 citation statements)

References 229 publications

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“…Tendinopathy; encompassing multifactorial tendon disorders characterised by pain and functional limitation remains a significant burden in musculoskeletal medicine. 1 Recent findings highlight a key role for immune mediated mechanisms in tendon disease supporting the concept that pivotal immunological and biomechanical factors conventionally associated with inflammatory rheumatic and musculoskeletal diseases (RMDs) are manifest in tendon. 2 Single cell technologies 3 (scRNAseq) are increasingly applied in rheumatology to identify key cellular phenotypes that drive disease pathogenesis.…”

Section: Single Cell and Spatial Transcriptomics In Human Tendon Disease Indicate Dysregulated Immune Homeostasismentioning

confidence: 90%

Single cell and spatial transcriptomics in human tendon disease indicate dysregulated immune homeostasis

et al. 2021

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Section: Single Cell and Spatial Transcriptomics In Human Tendon Disease Indicate Dysregulated Immune Homeostasismentioning

confidence: 90%

Single cell and spatial transcriptomics in human tendon disease indicate dysregulated immune homeostasis

et al. 2021

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“…Exposure to these factors leads to persistent liver inflammation and progressive liver fibrosis that often leads to cirrhosis. Liver cirrhosis generates a pro-tumorigenic microenvironment that promotes the transformation of pre-malignant lesions into highly proliferating neoplastic foci, a mechanism that accounts for up to 90% of HCC cases [ 120 ]. This process is initiated by activating mutations in the telomerase (TERT) gene, considered a gatekeeper of early hepatocarcinogenesis.…”

Section: Lncrnas In the Hallmarks Of Hccmentioning

confidence: 99%

The Landscape of lncRNAs in Hepatocellular Carcinoma: A Translational Perspective

Unfried

Sangro

Prats-Mari

et al. 2021

Cancers

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LncRNAs are emerging as relevant regulators of multiple cellular processes involved in cell physiology as well as in the development and progression of human diseases, most notably, cancer. Hepatocellular carcinoma (HCC) is a prominent cause of cancer-related death worldwide due to the high prevalence of causative factors, usual cirrhotic status of the tumor-harboring livers and the suboptimal benefit of locoregional and systemic therapies. Despite huge progress in the molecular characterization of HCC, no oncogenic loop addiction has been identified and most genetic alterations remain non-druggable, underscoring the importance of advancing research in novel approaches for HCC treatment. In this context, long non-coding RNAs (lncRNAs) appear as potentially useful targets as they often exhibit high tumor- and tissue-specific expression and many studies have reported an outstanding dysregulation of lncRNAs in HCC. However, there is a limited perspective of the potential role that deregulated lncRNAs may play in HCC progression and aggressiveness or the mechanisms and therapeutic implications behind such effects. In this review, we offer a clarifying landscape of current efforts to evaluate lncRNA potential as therapeutic targets in HCC using evidence from preclinical models as well as from recent studies on novel oncogenic pathways that show lncRNA-dependency.

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“…The management of tendinopathy usually involves the use of non-steroidal and steroidal anti-inflammatory medications, physical therapy, exercise therapy, and surgery (Andres and Murrell, 2008 ; Millar et al, 2021 ). Evidence also suggests that active exercise compared to passive treatment and the addition of manual therapy shorten the time to return to sport in athletes with history of groin pain (Serner et al, 2015 ).…”

Section: Background/contextmentioning

confidence: 99%

The Case of Insertional Adductor Tendinopathy of an International-Level 3,000-m Steeplechase Runner

Thomas

Giaccone

Iovane

et al. 2021

Front. Sports Act. Living

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Background: Groin pain is a frequent condition among athletes. One of the causes of groin pain is tendinopathy, a frequently diagnosed medical condition, which can also occur in the adductor muscles. Despite the high prevalence of this medical condition among athletes, it is infrequent to observe tendinopathic groin pain in steeplechase runners. The aim of this case study is to describe the case of an international-level 3,000-m steeplechase runner with groin pain, who was subsequently diagnosed with adductor insertional tendinopathy.Case Presentation: We present the case of an Italian 3,000-m steeplechase and long distance runner, Ala Zoghlami (180 cm, 57 kg), with groin pain, diagnosed as insertional adductor tendinopathy. The runner, after manifesting the painful symptomatology, underwent medical screening (ultrasound and MRI). The radiological investigations highlighted adductor tendinopathy. After refraining from training, the runner underwent medical and physical therapy which, in the first phase, did not improve the painful symptomatology. Further evaluation, after 6 months from the initial training cessation, highlighted a case of malocclusion. Such was treated from a dentistry perspective with the creation of a personalized dental bite.Results: A multidisciplinary approach which included medical and physical therapy, osteopathy, and dentistry, in adjunct with refraining from training, was able to reduce the symptomatology and allowed a correct return to run (after 9 months from the first painful manifestation) of the steeplechase runner. To date, Ala Zoghlami has fully recovered and was able to win the 3,000-m steeplechase race during the 2021 national Italian competition.

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Tendinopathy

Cited by 379 publications

References 229 publications

Single cell and spatial transcriptomics in human tendon disease indicate dysregulated immune homeostasis

Single cell and spatial transcriptomics in human tendon disease indicate dysregulated immune homeostasis

The Landscape of lncRNAs in Hepatocellular Carcinoma: A Translational Perspective

The Case of Insertional Adductor Tendinopathy of an International-Level 3,000-m Steeplechase Runner

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