this research aimed to study the effect of pomegranate peel and molasses incorporated in roasted meat balls on the general acceptability of the product and its protective effects on renal failure (RF) induced by excessive dietary arginine in rats. PG peel powder ant PG molasses, and their mix were incorporated into meat balls at levels of 3, 5 and 8%. Proximate chemical composition and sensory properties of meat balls were evaluated. Meat balls with 3% PG peel, 5% PG molasses and 5% PG peel&molasses mix were chosen for biological evaluation. The results revealed that renal Failure induced by excessive L-arginine in rats caused a decrease in body weight gain, feed efficiency ratio, protein efficiency ratio, albumin, globulin, total protein, total antioxidants capacity, SOD, GSH, and CAT. It also increased serum biomarkers of renal function, C-reactive protein, tumor nicrosis factor-α (TNF-a) and TBARs. Coadministration of pomegranate derivatives alleviates oxidative stress and mitigated all renal failure signs. It can be concluded that meat balls contained pomegranate peel (3%), molasses (5%) and their mix (5%) received an acceptable sensory scores and exhibited renoprotective efficacy can be attributed to their antioxidant and anti-inflammatory aspects. MATERIALS AND METHODS Plant materials: Pomegranate Punica granatum peels, pomegranate molasses (provided by Alfa Inter Food Co. Lebanon), beef red meat, onion, salt, black pepper, burgul were obtained from the local market in Cairo city, Egypt. Chemicals: Arginine, casein, vitamins, minerals, cellulose and choline chloride were purchased from El-Nasr Pharm. and Chem. Ind. Comp. Cairo, Egypt. Corn oil and corn starch were obtained from local market. Kits used to determine serum biochemical parameters were purchased from Biodiagnostic Company, Dokki, Giza, Egypt. Methods Meat balls preparation 100g of pomegranate fresh peel (79.22% moisture) were washed with water, cut into small pieces and placed in a hot air oven at 60 0C for 18 h to be dried. The dried materials (66.41% moisture) were crushed by food grinder in to powder form up to completely pass through 0.5 mm size sieve. Powder was transferred polyethylene bags until use (Kushwaha et al. 2013). Bulgur was soaked in double amount of water (20°C±1) for 15 minutes and drained. Fats were removed from the meat to get the lean tissues. Three formulas of meat balls were prepared. Meat balls (MB) consists of meat 86%, bulgur 10% (to reduce loss of water and nutrients during cooking), onion 1%,