Tender solitary lesion in vulvar lichen sclerosus

Saeed, Lina; Lee, Bonnie; Kraus, Christina N.

doi:10.1016/j.jdcr.2022.01.038

Cited by 2 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A few cases of associations of PCV with lichen sclerosus have been reported 14,22,23 . In our study, 15/35 cases of PCV were associated with clinical signs of lichen planus or sclerosus (secondary PCV).…”

Section: Discussionsupporting

confidence: 51%

See 1 more Smart Citation

Plasma Cell Vulvitis: A Classification Into Two Clinical Phenotypes

Wendling,

Plantier,

Moyal-Barracco

2023

J Low Genit Tract Dis

View full text Add to dashboard Cite

Objective The etiology of plasma cell vulvitis (PCV) is debated. The authors aimed to test the hypothesis that PCV could be divided into 2 clinical phenotypes. Methods Patients with a clinico-pathological diagnosis of PCV and with available vulvar photos seen in a vulvar clinic were retrospectively studied. The cases of PCV were divided into 2 groups: non–lichen-associated (primary PCV) and lichen-associated (secondary PCV). The 2 groups were compared in terms of age, menopausal status, location of the PCV, and 12 histologic parameters (Fisher exact test, p < .05). Results Thirty-five patients (20 primary and 15 secondary PCV) were included. The 2 groups did not differ in terms of age (mean, 65; range, 50–85) or menopausal status. Primary PCV was located exclusively on the vestibule for 19/20 patients, whereas secondary PCV was extravestibular for 14 of 15 patients, either exclusively (2) or both extravestibular and vestibular (12). One patient with secondary PCV had solely vestibular involvement. Five histological features were observed significantly more often in case of secondary PCV: epidermal atrophy, parakeratosis, dermal and epidermal neutrophils, and dermal eosinophils. Conclusions Plasma cell vulvitis can be divided clinically into 2 phenotypes. Primary non–lichen-associated PCV is restricted to the vestibule and could be the vulvar counterpart of atrophic vaginitis. Secondary lichen-associated PCV is both extravestibular and vestibular, and its clinical and histological features should be looked for outside the PCV areas. This division of PCV into 2 clinical phenotypes could have therapeutic implications.

show abstract

Section: Discussionsupporting

confidence: 51%

“…21 A few cases of associations of PCV with lichen sclerosus have been reported. 14,22,23 In our study, 15/35 cases of PCV were associated with clinical signs of lichen planus or sclerosus (secondary PCV). The clinical diagnosis of lichen was histologically confirmed by a biopsy taken from the PCV site for only 1 patient (Figure 3).…”

Section: Discussionmentioning

confidence: 49%

Plasma Cell Vulvitis: A Classification Into Two Clinical Phenotypes

Wendling,

Plantier,

Moyal-Barracco

2023

J Low Genit Tract Dis

View full text Add to dashboard Cite

show abstract

“…Another comparative study of vulvar epithelial nonneoplastic lesions treated with dot-matrix CO 2 laser was performed. The findings revealed a remarkable improvement in the itching of the vulva and pain during intercourse without adverse effects ( 8 , 9 ). This may be related to the thermal response of the laser inducing tissue edema and the release of HSP70 and transforming growth factor beta (TGF) ( 10 ), which in turn improves skin circulation and nutrition in the localized nonneoplastic lesions of the vulvar epithelium and repairs damaged tissue from local scratching ( 1 ).…”

Section: Discussionmentioning

confidence: 99%

A retrospective comparative cohort study of ultra-pulse CO2 lattice laser and glucocorticoids in the treatment of vulvar epithelial nonneoplastic lesions

Wei¹,

Li²,

Zhang³

et al. 2023

Ann Transl Med

View full text Add to dashboard Cite

Background: A comparison of topical glucocorticoids with CO 2 fractional laser treatment was conducted to investigate the differences in the efficacy of non-neoplastic vulvar epithelial lesion treatments in different pathological types and to provide a scientific basis for the management of these disorders. This paper was to study the difference of curative effect of different pathological types of non-tumor vulvar epithelial lesions and provide scientific basis for the treatment of these diseases. Methods:From November 2016 to July 2018, 178 cases of vulvar lichen simplex chronicus (LSC) or lichen sclerosus were confirmed with vulvar biopsy at our institute. Finally, 160 patients were enrolled in this trial. The patients were divided into 2 groups: a group treated with topical hormone and a group treated with CO 2 lattice laser therapies. There were 80 cases in each group, including 40 with LSC and 40 with lichen sclerosus. Patients applied 1 gram of progesterone cream and betamethasone cream to the affected area in the morning and evening, respectively, once a day for 3 months. The efficacy was evaluated with the Patient Global Impression of Change (PGI-C) subjective symptom improvement scale and clinical efficacy evaluation scale. The formula was applied to calculate the curative effect index. Results:The PGI-C scores at 1, 3, and 6 months of treatment showed that the laser treatment group had remarkably superior outcomes to the glucocorticoid treatment group. The clinical efficacy score scale at 3and 6-month treatments indicated a significantly greater curative effect in the laser than in the glucocorticoid treatment (P=0.006 and P=0.002 respectively). In the glucocorticoid group, the clinical effects of different pathological subtypes were significantly different following the 1-and 3-month treatments. The efficacy of treatment for LSC was better than that for lichen sclerosus. Following the 3-and 6-month treatments, the clinical effect for LSC was better than that of lichen sclerosus (3 months: 95% vs. 75%; 6 months: and 95% vs. 70%).Conclusions: Ultrapulse CO 2 lattice laser was more effective than was glucocorticoid therapy in the treatment of vulvar epithelial non-tumor-like lesions.

show abstract

Tender solitary lesion in vulvar lichen sclerosus

Cited by 2 publications

References 3 publications

Plasma Cell Vulvitis: A Classification Into Two Clinical Phenotypes

Plasma Cell Vulvitis: A Classification Into Two Clinical Phenotypes

A retrospective comparative cohort study of ultra-pulse CO2 lattice laser and glucocorticoids in the treatment of vulvar epithelial nonneoplastic lesions

Contact Info

Product

Resources

About