“…Third, tender point count is variable with time within the same subject [39] and it is clearly influenced by psychological variables, such as individual's distress [40]. Fourth, tender point count is not associated with disability or pain intensity [39,41]. Furthermore, tender points are not sites of ongoing inflammation since no differences in concentrations of chemical mediators, for example, ATP, PGE2, glutamate, glucose, pyruvate and urea are observed between tender and nontender points [42].…”