Tendencias sociales de la enfermedad de Chagas para las próximas décadas

Dias, João Carlos Pinto

doi:10.1590/s1851-82652012000300010

Cited by 3 publications

(2 citation statements)

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“…A total of 8 million people in 21 countries are infected by the disease with mortality rates of approximately 10,000 per year. This parasitosis is found in particular landscapes inhabited by mammal reservoirs and insect vectors (Hemiptera, Reduviidae, Triatominae), which together make up the wild cycle, the most primitive zoonotic transmission dynamic, in which the parasite travels between more than 200 species of mammals from seven orders and about 140 species of insects in 15 genera ( 1 , 2 ).…”

Section: Introductionmentioning

confidence: 99%

“…In both cases, T. cruzi infects individuals giving rise to the so-called peridomestic and domestic Chagas’ disease cycles. This accidental anthropozoonosis may develop in rural as well as urban areas and is conditioned by both environmental and social elements ( 1 , 5 ). In Venezuela, T. cruzi circulates between 39 species in the Marsupiala, Edentata = Xenartra, Chiroptera, Carnivora, Rodentia, Primates, and Lagomorpha and is transmitted by 22 insect vectors.…”

Section: Introductionmentioning

confidence: 99%

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Chagasâ€™ Disease: An Emergent Urban Zoonosis. The Caracas Valley (Venezuela) as an Epidemiological Model

Urdaneta‐Morales

2014

Front. Public Health

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The unprecedented emergence of important public health and veterinary zoonoses is usually a result of exponential population growth and globalization of human activities. I characterized Chagas’ disease as an emergent zoonosis in the Caracas Valley (Venezuela) due to the following findings: the presence of reservoirs (Didelphis marsupialis, Rattus rattus) and vectors (Panstrongylus geniculatus, Panstrongylus rufotuberculatus) infected with Trypanosoma cruzi in urbanized or marginalized areas; the elevated contact between P. geniculatus and human beings detected by parasitological and molecular examinations of triatomine feces demonstrated the possibility of transmission risks; a study of outbreaks of urban Chagas’ disease reported the first proven case of oral transmission of T. cruzi to human beings; the risk of transmission of glandular metacyclic stages from marsupials by experimental ocular and oral instillation; mice genitalia infected with T. cruzi contaminated blood resulted in the formation of amastigotes very close to the lumen suggesting that there may be a possibility of infection via their release into the urine and thence to the exterior; the ubiquitous histotropism and histopathology of T. cruzi was demonstrated using a mouse model; the presence of experimental T. cruzi pseudocysts in adipose, bone-cartilage, and eye tissue indicated a potential risk for transplants. Socio-sanitary programs that include improvements in housing, vector control, and access to medical treatment, as well as strategies aimed at combating social inequalities, poverty, and underdevelopment should be undertaken in those areas where zoonoses are most prevalent. Disciplines, such as Ecology, Epidemiology, Medical Entomology, Human and Veterinary Medicine, Environmental Studies, Public Health, Social and Political Studies, Immunology, Microbiology, and Pharmacology could all provide important contributions that aim to reduce the occurrence of factors governing the spread of emergent diseases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%