2017
DOI: 10.3389/fnint.2017.00030
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Tenascins in Retinal and Optic Nerve Neurodegeneration

Abstract: Tenascins represent key constituents of the extracellular matrix (ECM) with major impact on central nervous system (CNS) development. In this regard, several studies indicate that they play a crucial role in axonal growth and guidance, synaptogenesis and boundary formation. These functions are not only important during development, but also for regeneration under several pathological conditions. Additionally, tenascin-C (Tnc) represents a key modulator of the immune system and inflammatory processes. In the pr… Show more

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Cited by 42 publications
(44 citation statements)
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“…Moreover, non-fibril-forming collagens and collagen-like proteins are widely expressed in CNS (Hubert et al, 2009;Humphries et al, 1988;Lein et al, 1991), with some specific forms being expressed by neurons (Fox et al, 2007;Hubert et al, 2009;Sund et al, 2001). The tenascin family of oligomeric glycoproteins, recognised by α7β1, α8β1 and α9β1 integrins, mediate neuron-glia interactions and can exert both inhibitory and stimulatory effects on cell motility (Mercado et al, 2004;Reinhard et al, 2017;Varnum-Finney et al, 1995). Thrombospondins are a family of extracellular matrix proteins, shown to promote neurite outgrowth via α1β1, α3β1 and αvβ1 integrins (DeFreitas et al, 1995;Bamdad et al, 2004;Neugebauer et al, 1991;Charrier et al, 2010).…”
Section: Box 2 Integrin Ligands In the Cnsmentioning
confidence: 99%
“…Moreover, non-fibril-forming collagens and collagen-like proteins are widely expressed in CNS (Hubert et al, 2009;Humphries et al, 1988;Lein et al, 1991), with some specific forms being expressed by neurons (Fox et al, 2007;Hubert et al, 2009;Sund et al, 2001). The tenascin family of oligomeric glycoproteins, recognised by α7β1, α8β1 and α9β1 integrins, mediate neuron-glia interactions and can exert both inhibitory and stimulatory effects on cell motility (Mercado et al, 2004;Reinhard et al, 2017;Varnum-Finney et al, 1995). Thrombospondins are a family of extracellular matrix proteins, shown to promote neurite outgrowth via α1β1, α3β1 and αvβ1 integrins (DeFreitas et al, 1995;Bamdad et al, 2004;Neugebauer et al, 1991;Charrier et al, 2010).…”
Section: Box 2 Integrin Ligands In the Cnsmentioning
confidence: 99%
“…These functions are not only important during development but also for regeneration under several pathological conditions. Tenascin C represents a key modulator in the immune system and inflammatory processes [152]. It is not only involved in barrier formation, but it is also a constituent of the glial scar after injury.…”
Section: Biomechanics Of the Laminar Regionmentioning
confidence: 99%
“…Tenascin‐R (TN‐R) is another subtype of tenascin. Expression of TN‐C can be found in other systems while TN‐R is restricted to the nervous system . TN‐R contains an amino‐terminal region rich in cysteine and have two distinct domains, epidermal growth factor‐like repeats (EGFL), and fibronectin type III (FN6‐8) homologous repeats.…”
Section: Functions Of Matrix Materials In Neural Differentiation Frommentioning
confidence: 99%