Tenascin‐C in primary malignant melanoma of the skin

Ilmonen, Suvi; Jahkola, Tiina; Turunen, Juha Pekka; Muhonen, Timo; Asko‐Seljavaara, Sirpa

doi:10.1111/j.1365-2559.2004.01976.x

Cited by 32 publications

(20 citation statements)

References 35 publications

(45 reference statements)

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“…These proteins were either not identified or were identified at very low abundance in the the collagen and non-injected SOC controls. Increases in the abundance of TN-C have been documented in MGP melanomas, and it has been suggested that relatively low levels of TN-C expression may be associated with a lower risk for metastasis19. Like TN-C, fibronectin is another protein implicated in melanoma invasion.…”

Section: Resultsmentioning

confidence: 99%

Proteomic Analysis of Laser Microdissected Melanoma Cells from Skin Organ Cultures

et al. 2010

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Gaining insights into the molecular events that govern the progression from melanoma in situ to advanced melanoma, and understanding how the local microenvironment at the melanoma site influences this progression, are two clinically pivotal aspects that to date are largely unexplored. In an effort to identify key regulators of the crosstalk between melanoma cells and the melanoma-skin microenvironment, primary and metastatic human melanoma cells were seeded into skin organ cultures (SOCs), and grown for two weeks. Melanoma cells were recovered from SOCs by laser microdissection and whole-cell tryptic digests analyzed by nanoflow liquid chromatography-tandem mass spectrometry with an LTQ-Orbitrap. The differential protein abundances were calculated by spectral counting, the results of which provides evidence that cell-matrix and cell-adhesion molecules that are upregulated in the presence of these melanoma cells recapitulate proteomic data obtained from comparative analysis of human biopsies of invasive melanoma and a tissue sample of adjacent, non-involved skin. This concordance demonstrates the value of SOCs for conducting proteomic investigations of the melanoma microenvironment.

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Section: Resultsmentioning

confidence: 99%

Proteomic Analysis of Laser Microdissected Melanoma Cells from Skin Organ Cultures

et al. 2010

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“…In many cancer forms, such as breast [14, 15], lung [16], brain [17], urological [18, 19], malignant melanoma [20], pheochromocytoma [21], cholangiocarcinoma [22] and adipocytic tumors [23], a high tenascin-C expression has been correlated with a poor patient survival [5, 6]. While this correlation applies to some cancers, there are also reports where tenascin-C expression correlates with a lower stage of disease and a better patient outcome [5, 6, 24, 25].…”

Section: Introductionmentioning

confidence: 99%

Tenascin-C Expression and Its Prognostic Significance in Colorectal Cancer

Lundin¹,

Nordling

Lundin³

et al. 2007

Oncology

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Objective: The extracellular matrix glycoprotein tenascin-C has been proposed as a tumor marker with prognostic significance in many cancer forms, but in colorectal cancer, reported results have been controversial. The aim of this study was to evaluate the prognostic value of immunohistochemical tenascin-C expression in a series of 231 patients with colorectal cancer. Methods: Paraffin-embedded formalin-fixed specimens were stained with a tenascin-C-specific monoclonal antibody, and the stromal staining intensity and pattern were analyzed. Results: Tenascin-C immunoreactivity was observed in all 231 specimens, with a pattern of staining that was diffuse and interstitial. The staining was occasional in 39 (17%), moderate in 106 (46%) and strong in 86 specimens (37%). There was no statistically significant association between tenascin-C immunoreactivity and any of the other clinicopathological variables. The cumulative 5-year survival rates of patients with occasional and weak staining were similar (56.8 and 54.9%, respectively), while the patients with strong tenascin-C staining had a lower survival rate (46.1%). This difference in survival was not significant (p = 0.23). The staining pattern and distribution can be viewed from digitized representative microscope slides (virtual slides) at http://www.webmicroscope.net/supplements/tenascin. Conclusions: Our results indicate that immunohistochemical expression of tenascin-C is not of prognostic significance in colorectal cancer.

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“…It is not expressed in most adult normal tissues but transiently reappears after injury and regulates cell behavior by modulating cell adhesion [22]. It is linked to diverse reactive conditions such as inflammation and wound healing [28] as well as pathologic states including vascular disease and metastasis [21]. The growth-promoting properties of tenascin are due to the epidermal growth factor-(EGF-)like repeats contained in the protein [41].…”

Section: Discussionmentioning

confidence: 99%

Früheffekte einer Rhenium-188-Behandlung auf Proliferation, Migration und Matrixsynthese humaner aortaler glatter Muskelzellen in vitro

Kehlbach¹,

Dittmann

Schmid³

et al. 2006

Strahlenther Onkol

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Tenascin‐C in primary malignant melanoma of the skin

Abstract: In primary melanoma of the skin, absence of Tn-C in the stroma of invasion fronts and within tumour cells seems to be related to a more benign disease behaviour with a lower risk of developing metastases.

Cited by 32 publications

References 35 publications

Proteomic Analysis of Laser Microdissected Melanoma Cells from Skin Organ Cultures

Proteomic Analysis of Laser Microdissected Melanoma Cells from Skin Organ Cultures

Tenascin-C Expression and Its Prognostic Significance in Colorectal Cancer

Früheffekte einer Rhenium-188-Behandlung auf Proliferation, Migration und Matrixsynthese humaner aortaler glatter Muskelzellen in vitro

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