Ten years of experience with cavinton

Multidisciplinary Approach on Characterizing a Mechanochemically Activated Composite of Vinpocetine and Crospovidone

“…2 disorders and related symptoms. 4 It is mainly used as oral dosage forms, usually in tablets, containing 5 mg of active ingredient, with a daily dosage regimen that can vary between 5 mg 3/day and 20 mg 3/day. 5 However, existing formulations exhibit poor bioavailability (∼6.7%) [6][7] and poor absorption.…”

Enhanced Oral Bioavailability of Vinpocetine Through Mechanochemical Salt Formation: Physico-Chemical Characterization and In Vivo Studies

“…It has been shown to improve cerebral circulation and metabolism in the management of various types of cerebrovascular circulatory disorders, e.g. cerebral infarction, cerebral hemorrhage residual and cerebral arteries cirrhosis (2), and for the treatment of cognitive disorders and related symptoms (3). However, as a consequence of its low aqueous solubility and wettability, and extensive metabolism during first pass, VIN suffers from poor oral bioavailability (~6.7%) (4,5).…”

Dual catheter technique for the treatment of severe coronary artery perforations

“…It has been shown to improve cerebral circulation and metabolism in the treatment of various types of cerebrovascular circulatory disorders, for example, cerebral infarction, cerebral hemorrhage residual, and cerebral arteries cirrhosis, etc. VIN was introduced in clinical practice in Hungary for the treatment of cognitive disorders and related symptoms 4. It is mainly used as oral dosage forms, usually in tablets, containing 5 mg of active ingredient, with a daily dosage regimen that can vary between 5 mg_3/day and 20 mg_3/day 5.…”