Ten years of experience in lung cancer screening in Gdańsk, Poland: a comparative study of the evaluation and surgical treatment of 14 200 participants of 2 lung cancer screening programmes

Ostrowski, Marcin; Dziedzic, Robert; Jelitto-Górska, Małgorzata; Dziadziuszko, Katarzyna; Szurowska, Edyta; Dziadziuszko, Rafał; Rzyman, Witold

doi:10.1093/icvts/ivz079

Cited by 13 publications

(10 citation statements)

References 24 publications

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“…[28][29][30][31] The rate of early lung cancer cases diagnosed during the first round of screening in our cohort (1.34%, 7 cancers per 523 patients) was similar to that reported by other Polish screening university centers: 1.24% in Gdańsk and 0.7% in Szczecin. 43,44 Clinical studies have shown that emphysema with or without COPD is a significant risk factor of lung cancer, even in nonsmokers (hazard ratio, 1.66; 95% CI, 1.06-2.59). 45,46 The predictive value of COPD in lung cancer (high -risk group according to NCCN v. 2.2019) 14 is high enough to consider lower pack -year thresholds for screening eligibility.…”

Section: Referencesmentioning

confidence: 99%

Emphysema affects the number and appearance of solitary pulmonary nodules identified in chest low-dose computed tomography: a study on high risk lung cancer screenees recruited in Silesian District

Wachuła

Szabłowska-Siwik

Czyżewski

et al. 2019

Polish Archives of Internal Medicine

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INTROduCTION Chest low-dose computed tomography (LDCT) has recently been proved effective in lung cancer screening. ObjECTIvEs We aimed to assess the association between the occurrence of emphysema and solitary pulmonary nodules (SPNs) in first-round screening with LDCT. PATIENTs ANd mEThOds A total of 601 asymptomatic volunteers with a smoking history underwent LDCT; 523 patients were assigned to one of the following groups: E, emphysema without nodules (n = 103); E + N, emphysema with coexisting nodules (n = 96); N, nodules without emphysema (n = 142); and NENN, no nodules and no emphysema (n = 182). The effect of emphysema and demographic factors on the profile of SPNs was assessed. REsuLTs Patients in the E + N group were older than those in the N group (median age, 65 vs 63 years; P = 0.001) and they smoked more (median pack-years, 37.8 vs 32; P = 0.01). Emphysema was detected in 199 of the 523 patients (38%), while nodules, in 238 (45.5%). The number of nodules in the E + N group was 390 (4.1 nodules per patient), and in the N group, 540 (3.8 nodules per patient). Multiple SPNs, of different size and morphology, constituted 93.3% of the nodules in the E + N group. Seven cases of cancer were detected among 238 patients with nodules, and their distribution was similar in the groups with and without emphysema (4.2 per 100 patients in the E + N group and 2.1 per 100 in the N group; P = 0.44). CONCLusIONs Emphysema was more frequently associated with multiple SPNs of different morphology among elderly patients with a higher number of smoking pack-years. EdITORIAL by Chilet-Rosell and Lumbreras, see p. 4

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Section: Referencesmentioning

confidence: 99%

Emphysema affects the number and appearance of solitary pulmonary nodules identified in chest low-dose computed tomography: a study on high risk lung cancer screenees recruited in Silesian District

Wachuła

Szabłowska-Siwik

Czyżewski

et al. 2019

Polish Archives of Internal Medicine

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“…This study assessed the performance of these three risk prediction models in a large lung cancer screening cohort from Gdańsk, Poland. Throughout last ten years over 15,250 individuals have been screened in two lung cancer screening programmes in one screening centre (11,12). This retrospective study was based on full data collected during the latest screening programme conducted in Gdańsk-the MOLTEST BIS programme.…”

Section: Discussionmentioning

confidence: 99%

“…Detailed methodology of the screening management in the MOLTEST BIS programme was the subject of the previous publication (11). Primarily, the MOLTEST BIS programme was a validation study for the early lung cancer biomarkers, which were discovered in our previous lung cancer screening programme (12).…”

Section: Moltest Bis Programmementioning

confidence: 99%

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Performance of various risk prediction models in a large lung cancer screening cohort in Gdańsk, Poland—a comparative study

Ostrowski

Bińczyk

Dziedzic

et al. 2021

Transl Lung Cancer Res

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Background: Optimal selection criteria for the lung cancer screening programme remain a matter of an open debate. We performed a validation study of the three most promising lung cancer risk prediction models in a large lung cancer screening cohort of 6,631 individuals from a single European centre. Methods: A total of 6,631 healthy volunteers (aged 50-79, smoking history ≥30 pack-years) were enrolled in the MOLTEST BIS programme between 2016 and 2018. Each participant underwent a low-dose computed chest tomography scan, and selected participants underwent a further diagnostic work-up. Various lung cancer prediction models were applied to the recruited screenees, i.e., (I) Tammemagi's Prostate, Colorectal, and Ovarian Cancer Screening Trial 2012 (PLCO m2012 ), (II) Liverpool Lung Project (LLP) model, and (III) Bach's lung cancer risk model. Patients (I) with 6-year lung cancer probability ≥1.3% were considered as high risk in PLCO m2012 model, (II) in LLP model with 5-year lung cancer probability ≥5.0%, and (III) in Bach's model with 5-year lung cancer probability ≥2.0%. The particular model cut-off values were employed to the cohort to evaluate each model's performance in the screened population. Results: Lung cancer was diagnosed in 154 (2.3%) participants. Based on the risk estimates by PLCO m2012 , LLP and Bach's models there were 82.4%, 50.3% and 19.8% of the MOLTEST BIS participants, respectively, who fulfilled the above-mentioned threshold criteria of a lung cancer development probability. Of those detected with lung cancer, 97.4%, 74.0% and 44.8% were eligible for screening by PLCO m2012 , LLP and Bach's model criteria, respectively. In Tammemagi's risk prediction model only four cases (2.6%) would have been missed from the group of 154 lung cancer patients primarily detected in the MOLTEST BIS. Conclusions: Lung cancer screening enrollment based on the risk prediction models is superior to NCCN Group 1 selection criteria and offers a clinically significant reduction of screenees with a comparable proportion of detected lung cancer cases. Tammemagi's risk prediction model reduces the proportion of patients eligible for inclusion to a screening programme with a minimal loss of detected lung cancer cases.

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“…Stage I was diagnosed in 64% to 70% of detected cancers. 5 The results of these studies contributed to the awareness of the risk of lung cancer in society and established a knowledge-base on the low-dose CT for early lung cancer detection. The final results of the National Lung Screening Trial 6 and NELSON trial 7 prompted the development of the first Polish large-scale lung cancer early detection program.…”

Section: Lung Cancer Screeningmentioning

confidence: 99%

Lung Cancer in Poland

Adamek

Biernat

Chorostowska‐Wynimko³

et al. 2020

Journal of Thoracic Oncology

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In 2017, over 22,000 Poles have been diagnosed with lung cancer. Incidence rates among men and women are 93 and 38 per 100,000, respectively, based on the European Standard Population (2013). 1 Lung cancer ranks as the most prevalent malignancy overall, with approximately 18% of cancer cases among men and 10% among women. Lung cancer is also the main cause of cancer-related deaths in both sexes (almost 30% among men and 17% among women) and is the cause of almost 6% of all deaths in Poland. Similar to many European countries, tobacco epidemics was on the rise since the beginning of the 20th century and peaked in the early 1990s (Fig. 1). 1,2 Since then, the increasing trend of lung cancer incidence in Polish men reversed. Despite predicted further decrease in incidence rates, the absolute number of lung cancers among men in Poland will continue to rise. This increase results from demographic changes, predominantly the aging of the population.

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Ten years of experience in lung cancer screening in Gdańsk, Poland: a comparative study of the evaluation and surgical treatment of 14 200 participants of 2 lung cancer screening programmes

Cited by 13 publications

References 24 publications

Emphysema affects the number and appearance of solitary pulmonary nodules identified in chest low-dose computed tomography: a study on high risk lung cancer screenees recruited in Silesian District

Emphysema affects the number and appearance of solitary pulmonary nodules identified in chest low-dose computed tomography: a study on high risk lung cancer screenees recruited in Silesian District

Performance of various risk prediction models in a large lung cancer screening cohort in Gdańsk, Poland—a comparative study

Lung Cancer in Poland

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