Ten years’ experience with year-round active surveillance of up to 19 respiratory pathogens in children

Weigl, Josef; Puppe, Wolfram; Meyer, Claudius U.; Berner, Reinhard; Förster, Johannes; Schmitt, H. J.; Zepp, Fred

doi:10.1007/s00431-007-0496-x

Cited by 84 publications

(100 citation statements)

References 35 publications

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“…Viruses also play critical roles in the development of ARI or pneumonia in young children. However, elucidating the roles of viral pathogens may be complex as a wide range of viruses, such as respiratory syncytial virus (RSV), human rhinovirus (HRV), influenza virus (FLU) A and FLU B, parainfluenza virus (PIV) and human metapneumovirus (hMPV), are associated with severe forms of childhood ARI including bronchiolitis and pneumonia [5][6][7][8][9]. A systematic review has estimated that 22% of severe ARI episodes among children are related to RSV infections [10].…”

Section: Introductionmentioning

confidence: 99%

Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections

et al. 2013

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Comprehensive population-based data on the role of respiratory viruses in the development of lower respiratory tract infections (LRTIs) remain unclear. We investigated the incidence and effect of single and multiple infections with respiratory viruses on the risk of LRTIs in Vietnam.Population-based prospective surveillance and a case-control study of hospitalised paediatric patients with acute respiratory infection (ARI) were conducted from April 2007 through to March 2010. Healthy controls were randomly recruited from the same community. Nasopharyngeal samples were collected and tested for 13 respiratory viruses using multiplex PCRs.1992 hospitalised ARI episodes, including 397 (19.9%) with LRTIs, were enrolled. Incidence of hospitalised LRTIs among children aged ,24 months was 2171.9 per 100 000 (95% CI 1947.9-2419.7). The majority of ARI cases (60.9%) were positive for at least one virus. Human rhinovirus (24.2%), respiratory syncytial virus (20.1%) and influenza A virus (12.0%) were the most common and 9.5% had multiple-viral infections. Respiratory syncytial virus and human metapneumovirus infections independently increased the risk of LRTIs. Respiratory syncytial virus further increased the risk, when co-infected with human rhinovirus, human metapneumovirus and parainfluenza virus-3 but not with influenza A virus. The casecontrol analysis revealed that respiratory syncytial virus and influenza A virus increased the risk of ARI hospitalisation but not human rhinovirus.Respiratory syncytial virus is the leading pathogen associated with risk of ARI hospitalisation and LRTIs in Vietnam. @ERSpublications RSV is the leading pathogen associated with risk of ARI hospitalisation and LRTIs in Vietnam

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Section: Introductionmentioning

confidence: 99%

Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections

et al. 2013

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“…Numerous studies have focused on the clinical and epidemiological characteristics of HMPV infection, but few have been population based, and consequently the available information on the incidence and burden of this disease remains scarce. In addition, few studies have been conducted over several years, which is essential to adequately evaluate incidence rates, given that the intensity of HMPV circulation may vary considerably in distinct seasons [8][9][10]. The main aim of this study was to accurately estimate the incidence rates of hospitalization for community-acquired HMPV infection in an unselected and well-defined population of infants and children aged <3 years from an area of northern Spain.…”

Section: Introductionmentioning

confidence: 99%

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

et al. 2008

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SUMMARYNumerous studies have been published on human metapneumovirus (HMPV) infection, but few have been population based. The main aim of this study was to estimate the incidence rate of hospitalization for community-acquired HMPV infection in infants and children aged <3 years. Between July 2004 and June 2007, 796 episodes (742 patients) of community-acquired acute respiratory infection were hospitalized. HMPV was detected in 90 episodes (11 . 3%). Fifty-nine episodes occurred in infants aged <1 year. The mean length of hospital stay was 6 . 2 days (range 2-31 days). Thirteen children required admission to the intensive care unit. Viral co-infections were detected in 46 episodes (51 . 1%). The incidence rate of hospitalization per 1000 inhabitants was 2 . 6 (95 % CI 2 . 1-3 . 2), lower than that for respiratory syncytial virus, but higher than that observed for the influenza and parainfluenza viruses. HMPV is a major respiratory pathogen that leads to a high hospitalization rate.

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“…4 Starting in 1996, we developed a multiplex-RT-PCR to detect nine 5,6 and then 19 different ARI pathogens (work in progress). Over a 10 year period and examining more than 20,000 specimens to date, rhinoviruses are most commonly encountered in children hospitalized for LRTI.…”

Section: Solutionsmentioning

confidence: 99%

“…This is followed by continuous RSV-activity the following (even) year, sometimes even throughout summer, to reach again an early peak in autumn/winter. 4 Likewise, rhythms can be detected for metapneumovirus and other paramyxoviruses, whereas adenovirus, enterovirus and rhinovirus are detected throughout the year. Whatever "test-system" is used, its limitations must be kept in mind and need to be communicated to the treating physicians.…”

Section: Solutionsmentioning

confidence: 99%

O início de uma nova era: teste sistemático para patógenos causadores de infecções agudas das vias aéreas superiores (IVAS) em crianças

Schmitt¹,

Gröndahl²,

Schaaff³

et al. 2007

J. Pediatr. (Rio J.)

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Ten years’ experience with year-round active surveillance of up to 19 respiratory pathogens in children

Cited by 84 publications

References 35 publications

Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections

Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

O início de uma nova era: teste sistemático para patógenos causadores de infecções agudas das vias aéreas superiores (IVAS) em crianças

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