Ten years' experience with an elemental diet in the management of Crohn's disease.

Whole body protein turnover in childhood Crohn's disease.

“…metry in 10 4 synthesis, as expected for studies carried out in the postabsorptive state. Mean rates of whole body protein synthesis and breakdown decreased markedly in both treatment groups (Table II) but there were no significant changes in protein balance (synthesis-breakdown) before and after treatment.…”

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AbstractIn order to investigate the effects of treatment on protein metabolism in childhood Crohn's disease whole body protein turnover was measured using a primed constant intravenous infusion of L-[1-'3C]leucine and mass spectrometry in 10

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Orocaecal transit time in patients with Crohn disease

“…Twelve of our 16 patients were reinvestigated after therapy with a semi-elemental, chemically defined diet for a period of 6 weeks. This kind of therapy is widely recognised to be effective in inducing remission of active CD [17,20,22,25], although this has been recently questioned [15]. There is an additional benefit in children and adolescents in that linear growth after dietary treatment is substantially better than in those patients given corticosteroids [14].…”

Nutritional modulation of the inflammatory response in inflammatory bowel disease- From the molecular to the integrative to the clinical

“…It is unclear what is the role of nutritional therapy in adults with CD [51][52][53] , although there is some evidence in Japan that enteral nutrition enjoys support as primary therapy [53] . In contrast to the generally agreed role in adults of enteral nutrition being useful to improve the patient's nutritional status as its main benefit, in children with CD enteral nutrition has a much clearer benefit to improve clinical, biochemical and growth parameters [55] , and may as well have a steroid sparing effect [56,57] .…”

“…The question remains as to the best way of analyzing the results when a large percentage of patients receiving diet therapy drop out because of unpalatibility or intolerance. Furthermore, some studies have shown no difference with elemental diets when compared to steroid therapy [48,52] . In children, elemental diets were associated with greater linear growth, while in adults these diets preserve nitrogen balance [55,56] .…”