“…Overuse of cancer screening tests, including mammography and Pap smear, in populations where evidence is lacking may contribute to the increasing cost of medical care and convey additional risks to individuals. 15,37 This study points to a need for longerterm follow-up on the population impact of the USPSTF recommendations on mammography rates, as well as breast cancer-associated morbidity and mortality. As research continues to reveal overuse of cancer screening in the U.S., we will need further research on how providers interpret and use recommendations on cancer screening, how patient-provider communication around mammography decisions might be improved, and where individualized recommendations for higher risk groups may be indicated.…”
“…Overuse of cancer screening tests, including mammography and Pap smear, in populations where evidence is lacking may contribute to the increasing cost of medical care and convey additional risks to individuals. 15,37 This study points to a need for longerterm follow-up on the population impact of the USPSTF recommendations on mammography rates, as well as breast cancer-associated morbidity and mortality. As research continues to reveal overuse of cancer screening in the U.S., we will need further research on how providers interpret and use recommendations on cancer screening, how patient-provider communication around mammography decisions might be improved, and where individualized recommendations for higher risk groups may be indicated.…”
“…Increased mammographic density contributes to a 22% false-negative rate and a high false-positive rate (56.2% cumulative risk after 10 examinations) in women less than 50 years of age (31,32). A recent study found that routine initial mammography was not clinically advantageous for women less than 35 years of age (33).…”
Rationale and Objectives. Near-infrared (NIR) diffuse optical spectroscopy and imaging may enhance existing technologies for breast cancer screening, diagnosis, and treatment. NIR techniques are based on sensitive, quantitative measurements of functional contrast between healthy and diseased tissue. In this study, the authors quantified the origins of this contrast in healthy breasts.
Materials and Methods.A seven-wavelength frequency-domain photon migration probe was used to perform noninvasive NIR measurements in the breasts of 28 healthy women, both pre-and postmenopausal, aged 18 -64 years. A diffusive model of light transport quantified oxygenated and deoxygenated hemoglobin, water, and lipid by their absorption signatures. Changes in the measured light-scattering spectra were quantified by means of a "scatter power" parameter.Results. Substantial quantitative differences were observed in both absorption and scattering spectra of breast as a function of subject age. These physiologic changes were consistent with long-term hormone-dependent transformations that occur in breast. Instrument response was not adversely affected by subject age or menopausal status.
Conclusion.These measurements provide new insight into endogenous optical absorption and scattering contrast mechanisms and have important implications for the development of optical mammography. NIR spectroscopy yields quantitative functional information that cannot be obtained with other noninvasive radiologic techniques.
We compared the long-term impact of 1-and 2-year screening mammography intervals using prognostic, screening, and outcome information for women aged 50 -74 years obtained from the Screening Mammography Program of British Columbia in two time periods, prior to 1997 (policy of annual mammography) and after 1997 (biennial mammography). Survival was estimated for both periods using a prognostic model and the expected rate of interval and screen-detected cancers. The likelihood of a screen-detected cancer with annual screening was 2.32 per thousand screens and with biennial screening was 3.32 per thousand screens. The prognostic profile of screen-detected cancers was better than that of interval cancers. Among both screen-detected and interval cancers, the prognostic profiles with annual and biennial screening were similar. The estimated breast cancer-specific survival rates for women undergoing annual and biennial screening mammography were 95.2 and 94.6% at 5 years, and 90.4 and 89.2% at 10 years, respectively. Annual compared to biennial mammography was associated with a 1.2% increase in the estimated 10-year breast cancer-specific survival for women aged 50 -74 years, diagnosed with invasive breast cancer after screening programme attendance.
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