Ten-Year Outcomes for Pathologic Node-Positive Patients Treated in RTOG 75-06

Ferumoxtran-10 MR Lymphography for Target Definition and Follow-up in a Patient Undergoing Image-Guided, Dose-Escalated Radiotherapy of Lymph Nodes upon PSA Relapse

“…Conventional dose radiotherapy of manifest metastatic lymph nodes results in a maximum of only 10-30% biochemical relapse-free survival after 10 years [11,12,23]. While the combination of radiotherapy and antihormonal therapy seems to improve results, biochemical relapse-free survival still falls short of 50% at 10 years [11].…”

Lymph node staging in clinically localized prostate cancer

“…In the light of the recent data from the RTOG, 11 the Mayo Clinic 14 and the Swedish trial, 13 there is a strong case for adopting a radical, combined modality approach to treating some men with node positive prostate cancer. This has major implications for the way that we stage the disease, since a false negative rate of 13%, by effectively denying one in eight men a chance of a cure, is no longer acceptable.…”

“…12 ± 14 RTOG 75-06 found a 10 y clinical cancer-free survival of 7% in men with pathologically proven nodal involvement who were treated with pelvic node dissection and radiotherapy, suggesting a curative role in a small proportion of cases for local therapy alone. 11 A retrospective comparison from MD Anderson, of 229 men with pathologically proven nodal disease, of whom 185 were managed by early androgen ablation and 44 by combined androgen ablation and radiotherapy, reported 5 y failure rates of 58% and 10%, respectively, suggesting a bene®t for the use of combined modality therapy over systemic treatment alone. 12 The results of a recently reported Swedish randomized study suggest that, in node positive patients, there may also be a bene®t for combined modality therapy over local treatment alone.…”

Role of Radiation Therapy for the Treatment of Lymph Nodes in Urologic Malignancies

“…[35][36][37][38] RT alone has been used primarily for palliation for men with known lymph node involvement. The natural history of node-positive prostate cancer treated with RT alone is best illustrated by a subset analysis of RTOG 7506.…”

“…The natural history of node-positive prostate cancer treated with RT alone is best illustrated by a subset analysis of RTOG 7506. 38 In a total of 90 men with regional node-positive prostate cancer, the 10-year survival rate was 29%. Only 5 patients were progression free at 10 years.…”