Ten-Year Outcome of Laparoscopic and Conventional Nissen Fundoplication

Broeders, Joris A.; Jong, Hilda G. Rijnhart-de; Draaisma, Werner A.; Bredenoord, Albert J.; Smout, A. J. P. M.; Gooszen, Hein G.

doi:10.1097/sla.0b013e3181bcdaa7

Cited by 151 publications

(48 citation statements)

References 35 publications

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“…20, 22, 23 At 10 years, Broeders et al reported resolution or improvement of symptoms in 92.4% of patients. 24 Kelly et al also reported improvement in symptoms at 10 years using a visual analog scale. 27 The other 4 studies report satisfaction/cure rates from 84.9–100%.…”

Section: Resultsmentioning

confidence: 97%

“…20–23 PPI use at 1–3 years ranged from 5.5–16.7% and rose to 15–26.6% at 10 years. 19, 21, 22, 24, 25, 27 Three prospective cohort studies compared the effectiveness of LF between PPI responsive and non-responsive populations [Table 2]. 28–30 All studies found symptom improvement in PPINR, though when compared to responders, symptom control was slightly lower.…”

Section: Resultsmentioning

confidence: 99%

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Review of antireflux procedures for proton pump inhibitor nonresponsive gastroesophageal reflux disease

Hillman

Yadlapati

Whitsett

et al. 2017

Diseases of the Esophagus

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Introduction Up to 40% of patients with gastroesophageal reflux disease (GERD) report persistent symptoms despite proton pump inhibitor (PPI) therapy. This review outlines the evidence for surgical and endoscopic therapies for the treatment of PPI non-responsive GERD. Material and Methods A literature search for GERD therapies from 2005–2015 in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews identified unique 2928 citations. Of those, 45 unique articles specific to surgical and endoscopic therapies for PPI non-responsive GERD were reviewed. Results Laparoscopic fundoplication (n=19) provides symptomatic and physiologic relief out to 10 years, though efficacy wanes with time. Magnetic sphincter augmentation (n=6) and transoral incisionless fundoplication (n=9) improve symptoms in PPI non-responders, and may offer fewer side effects than fundoplication, though long-term follow-up is lacking. Radiofrequency energy delivery (n=8) has insufficient evidence for routine use in treating PPI non-responsive GERD. Electrical stimulator implantation (n=1) and endoscopic mucosal surgery (n=2) are emerging therapies for the treatment of GERD. Discussion Laparoscopic fundoplication remains the most proven therapeutic approach. Newer anti-reflux procedures such as magnetic sphincter augmentation and transoral incisionless fundoplication offer alternatives with varying degrees of success, durability, and side effect profiles that may better suit individual patients. Larger head-to-head comparison trials are needed to better characterize the difference in symptom response and side effect profiles.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Review of antireflux procedures for proton pump inhibitor nonresponsive gastroesophageal reflux disease

Hillman

Yadlapati

Whitsett

et al. 2017

Diseases of the Esophagus

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“…GERD is a chronic disease and indications for surgery are an area of controversy, mainly because data concerning long-term efficacy are scanty [3]. Recently, 10-year follow-up studies showed high efficacy of laparoscopic antireflux surgery in terms of symptoms [22] and also acid reflux control [23] in patients with typical reflux symptoms responsive to PPI therapy. Currently, however, PPI-resistant heartburn/ regurgitation represent the most demanding clinical problem in GERD: it is the most common presentation of reflux syndromes in third referral gastrointestinal practices [2], and according to the American Gastroenterological Association, it should be considered the main indication for antireflux surgery [4].…”

Section: Discussionmentioning

confidence: 99%

Conventional versus robot-assisted laparoscopic Nissen fundoplication: a comparison of postoperative acid reflux parameters

Frazzoni¹,

Conigliaro

Colli

et al. 2011

Surg Endosc

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Robot-assisted LNF provided a significant gain in postoperative acid reflux parameters compared with the conventional technique. In a challenging clinical setting, such as PPI-refractoriness, in which the efficacy of endoscopic or pharmacological treatment modalities is only moderate, even a small therapeutic gain can be clinically relevant. In centers where robot-assisted LNF is available, it should be preferred to conventional LNF in PPI-refractory GERD.

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“…In fact, several studies reported that after surgery there are subjects who will get worse or exacerbate dyspepsia-like symptoms (epigastric fullness, bloating, abdominal pain, flatulence), with worsening in GERD symptom control in up to 50% at long term follow-up[36,37]. …”

Section: Clinical Factors: Symptomsmentioning

confidence: 99%

Pre-operative clinical and instrumental factors as antireflux surgery outcome predictors

Tolone

Gualtieri

Savarino

et al. 2016

WJGS

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Gastroesophageal reflux disease (GERD) is nowadays a highly prevalent, chronic condition, with 10% to 30% of Western populations affected by weekly symptoms. Many patients with mild reflux symptoms are treated adequately with lifestyle modifications, dietary changes, and low-dose proton pump inhibitors (PPIs). For those with refractory GERD poorly controlled with daily PPIs, numerous treatment options exist. Fundoplication is currently the most commonly performed antireflux operation for management of GERD. Outcomes described in current literature following laparoscopic fundoplication indicate that it is highly effective for treatment of GERD; early clinical studies demonstrate relief of symptoms in approximately 85%-90% of patients. However it is still unclear which factors, clinical or instrumental, are able to predict a good outcome after surgery. Virtually all demographic, esophagogastric junction anatomic conditions, as well as instrumental (such as presence of esophagitis at endoscopy, or motility patterns determined by esophageal high resolution manometry or reflux patterns determined by means of pH/impedance-pH monitoring) and clinical features (such as typical or atypical symptoms presence) of patients undergoing laparoscopic fundoplication for GERD can be factors associated with symptomatic relief. With this in mind, we sought to review studies that identified the factors that predict outcome after laparoscopic total fundoplication.

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Ten-Year Outcome of Laparoscopic and Conventional Nissen Fundoplication

Cited by 151 publications

References 35 publications

Review of antireflux procedures for proton pump inhibitor nonresponsive gastroesophageal reflux disease

Review of antireflux procedures for proton pump inhibitor nonresponsive gastroesophageal reflux disease

Conventional versus robot-assisted laparoscopic Nissen fundoplication: a comparison of postoperative acid reflux parameters

Pre-operative clinical and instrumental factors as antireflux surgery outcome predictors

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