Ten-year incidence of primary angle closure in elderly Chinese: the Liwan Eye Study

Wang, Lanhua; Huang, Wenyong; Huang, Shengsong; Zhang, Jian; Guo, Xinxing; Friedman, David S.; Foster, Paul J.; He, Miao

doi:10.1136/bjophthalmol-2017-311808

Cited by 47 publications

(30 citation statements)

References 19 publications

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“…The incidence of PAC/AACG in the untreated eyes in our study was 3.75%, which was very similar to that reported in a population based Indian cohort 4.4% per year [22]. In Liwan study, approximately one in five people aged 50 years and older developed some form of angle closure over a 10-year period [36]. However, two of the LPI treated eyes also developed increased IOP without PAS in our study.…”

Section: Discussionsupporting

confidence: 89%

Change in Angle of Eyes with Primary Angle Closure Suspects One Year after Laser Peripheral Iridotomy : a randomised study

Mou

Liang

Fan

et al. 2019

Preprint

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Background: To report the changes in anterior chamber angle and progression rate to PAC(primary angle closure) following laser peripheral iridotomy (LPI) in primary angle closure suspects(PACS). Methods: Prospective, randomized controlled interventional clinical trial conducted at the Handan Eye Hospital, China. 134 bilateral PACS, defined as non-visibility of the posterior trabecular meshwork for ≥ 180 degrees on gonioscopy were randomly assigned to undergo LPI in one eye. Gonioscopy and Goldmann applanation tonometry were performed prior to, on day 7 and 12 months’ post LPI. Results: 80 of 134 patients (59.7%) could be followed up at one year. The mean IOP in treated eyes was 15.9±2.7 mmHg at baseline, 15.4±3.0 mmHg on day 7; 16.5±2.9 mmHg at one month and 15.5±2.9 mmHg at 12 months; the IOP in untreated eyes was similar (p=0.834). One or more quadrants of the angle opened in 93.7% of the LPI treated eyes, but 67.0% (53/79) remained closed in two or more quadrants. The progression rate to PAC in untreated eyes was 3.75% and one developed acute angle closure glaucoma(AACG), the progression rate to PAC(primary angle closure) in treated eyes 2.5% in treated eyes, none had developed PAS or AACG. Conclusion: LPI can open some of the occludable angle in the majority of eyes with PACS, but 67% continue to have non-visibility of the trabecular meshwork for over 180 degrees. IOP remained similar in treated and untreated eyes. Further research is needed to determine the full implications of residual closure as well as the need for follow up and treatment in PACS. The cumulative incidence for PAC/AACG in treated eyes were not significantly different from untreated eyes. Trial registration: Current Controlled Trials Chinese Clinical Trial Registry ChiCTR-TCH-10000820, as well as the date of registration(retrospectively registered).

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Section: Discussionsupporting

confidence: 89%

Change in Angle of Eyes with Primary Angle Closure Suspects One Year after Laser Peripheral Iridotomy : a randomised study

Mou

Liang

Fan

et al. 2019

Preprint

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“…Further studies have been carried out to explore the changes of the angle structure of the anterior chamber after phacoemulsification by AS-OCT [1][2][3][4][5][6][7][8][9][10][11][12] .It has the advantage of allowing faster crosssectional imaging of the anterior chamber than UBM and does not require contact with the globe.…”

Section: Discussionmentioning

confidence: 99%

“…Small ocular dimensions and hyperopia at baseline were associated with the development of angle closure [12] .…”

Section: Introductionmentioning

confidence: 96%

Assessment of anterior chamber configuration changes after phacoemulsification with swept-source optical coherence tomography

Zheng

et al. 2020

Preprint

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Background: To assess the changes of anterior chamber angle in patients with shallow anterior chamber and normal anterior chamber after phacoemulsification and intraocular lens implantation (IOL) using anterior segment swept-source optical coherence tomography (AS-SS-OCT). Methods: This was a prospective case control study; 60 eyes of 60 patients who scheduled for cataract surgery with normal intraocular pressure (IOP). Based on anterior chamber depth (ACD) and gonioscopy findings, the eyes were classified into two groups: shallow anterior chamber group with narrow angle (SAC group, 30 eyes)；and normal anterior chamber group with wide angle (NAC group, 30 eyes). Measurements of ACD, anterior chamber volume (ACV), Iris volume (IV), lens vault (LV) , angle opening distance (AOD), angle recess area (ARA), trabecular iris space area (TISA), and trabecular iris angle (TIA) were conducted in each group before and 3 months after surgery. Differences between the two groups were compared. Results: There was no significant difference in age, axial length (AL), corneal curvature, corneal diameter, IOP and IV between the SAC group and the NAC group before operation, except for the LV (p = 0.000). All angle parameters including ACD, ACV, AOD, ARA, TISA and TIA in both groups at 3 months post-surgery were significantly different from the preoperative values (p<0.01). In addition, there were significant differences in all angle parameters between two groups before and after operation (All P< 0.05). Besides, the TISA750 in superior quadrant, ACD and ACV were significantly smaller in the group of SAC than those in the group of NAC 3 months after operation (P = 0.041, 0.001 and 0.002, respectively). Conclusions: Cataract surgery can deepen anterior chamber and increase the width of anterior chamber angle in Chinese subjects, but the ACD and ACV in patients with shallow anterior chamber and narrow angle have not reached the normal level, presumably because the iris root of SAC group inserted more anteriorly than that of NAC group. Phacoemulsification may not completely eliminate the risk of glaucoma in NAC group of people after surgery.

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“…Further studies have been carried out to explore the changes of the angle structure of the anterior chamber after phacoemulsification by AS-OCT [1][2][3][4][5][6][7][8][9][10][11][12] .It has the advantage of allowing rapidder crosssectional imaging of the anterior chamber than UBM and does not require contact with the globe.…”

Section: Discussionmentioning

confidence: 99%

Assessment of anterior chamber configuration changes after phacoemulsification with swept-source optical coherence tomography

Zheng

et al. 2019

Preprint

View full text Add to dashboard Cite

Background To assess the changes of anterior chamber angle in patients with shallow anterior chamber and normal anterior chamber after phacoemulsification and intraocular lens implantation (IOL) using anterior segment swept-source optical coherence tomography (AS-SS-OCT). Methods This was a prospective case control study; 60 eyes of 60 patients who underwent cataract surgery. Based on anterior chamber depth (ACD) and gonioscopy findings, the eyes were classified into two groups, shallow anterior chamber group (30 eyes) and normal anterior chamber group (30 eyes). AS-SS-OCT was used to measure ACD and angle parameters angle opening distance (AOD), angle recess area (ARA), trabecular iris space area(TISA), and trabecular iris angle (TIA). Serial changes in each group were measured before and 3 months after phacoemulsification and IOL, and the differences between the two groups were compared. Results All angle parameters including ACD, AOD, ARA, TISA, and TIA in both groups at 3 months after cataract surgery were significantly different from the preoperative values (p<0.01). In addition, we found significant differences of all angle parameters between groups of shallow anterior chamber (SAC) and normal anterior chamber (NAC) (All P< 0.05). Besides, the TISA750 in superior quadrant and anterior chamber volume (ACV) were significantly smaller in the group of SAC than those in the group of NAC (P = 0.041 and 0.002, respectively). Conclusions The parameters of anterior chamber increased significantly in both two groups but not increase to the same extent 3 months after phacoemulsification. Iris thickening may also be one of the narrow angle factors,not just age-related lens thickening.

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Ten-year incidence of primary angle closure in elderly Chinese: the Liwan Eye Study

Abstract: Purpose: To determine the 10-year incidence of all forms of primary angle closure in phakic eyes and its risk factors in an urban Chinese population aged 50 years and older. Methods

Cited by 47 publications

References 19 publications

Change in Angle of Eyes with Primary Angle Closure Suspects One Year after Laser Peripheral Iridotomy : a randomised study

Change in Angle of Eyes with Primary Angle Closure Suspects One Year after Laser Peripheral Iridotomy : a randomised study

Assessment of anterior chamber configuration changes after phacoemulsification with swept-source optical coherence tomography

Assessment of anterior chamber configuration changes after phacoemulsification with swept-source optical coherence tomography

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