Ten-Year Historic Cohort of Quality of Life and Sexuality in Patients With Rectal Cancer

Schmidt, Christian; Bestmann, Beate; Küchler, Thomas; Longo, Walter E.; Kremer, Bernd

doi:10.1007/s10350-004-0822-6

Cited by 146 publications

(85 citation statements)

References 40 publications

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“…11 In contrast to men, women who have radical cystectomy or surgery to remove rectal cancer have similar sexual function to healthy controls. 6,12 If pelvic surgery impairs vaginal expansion and lubrication, it seems that women can compensate by using estrogen replacement or water-based lubricants.…”

Section: Sexual Function Gender and Damage From Cancer Treatmentmentioning

confidence: 99%

Sexuality and Fertility after Cancer

Schover¹

2005

Hematology

164

124

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As more people achieve long-term survival after cancer, sexual dysfunction and infertility have increasingly been recognized as negative consequences that impact quality of life. Sexual dysfunction is a frequent long-term side effect of cancer treatment, but damage to different underlying physiological systems is salient in men versus women. Men frequently have erectile dysfunction (ED) related to damage to the autonomic nervous system and/or reduced circulation of blood to the penis. Hormonal impairment of sexual function is less common. Women, in contrast, are able to overcome damage to autonomic nerves if genital tissues remain structurally intact and estrogenized. Female sexual dysfunction is frequently associated with sudden premature ovarian failure or direct effects of radiation fibrosis or scar tissue causing pain with sexual activity. The lack of validated interventions for sexual rehabilitation after cancer is a major problem, as is finding cost-effective ways of providing services. Concerns about fertility are also a major source of distress to people treated for cancer during childhood or young adulthood, yet many young survivors do not recall any discussion about future childbearing potential with their oncology team. Since fertility preservation is becoming more practical for both men and women, producing patient and professional educational materials and developing professional practice guidelines should be high priorities for oncology societies.As long as cancer treatments cannot be exclusively targeted to tumor cells, damage to the reproductive system will remain an important aspect of cancer morbidity. Problems with sexual function and fertility after cancer are not only ubiquitous, they are less likely to resolve with time than most other treatment side effects. Although not every cancer survivor cares about remaining sexually active, longterm sexual dysfunction has been documented in at least 50% of those treated for breast, prostate, colorectal or gynecological cancer.1 Most available information about sexual dysfunction and fertility is from patients treated for solid tumors. Distress about cancer-related infertility is typically highest among those diagnosed in their reproductive years. Although a much smaller percentage of people treated for cancer are affected by infertility than by sexual dysfunction, 1 in 71 men and 1 in 51 women are diagnosed with a malignancy before age 39.2 Although some cancer treatments can cause both sexual dysfunction and infertility, these two types of morbidity are frequently independent. For example, many young men treated with chemotherapy have poor semen quality, but with all but the highdose regimens, their testosterone levels and sexual function remain normal.3 Therefore, sexual function and fertility will be discussed in separate sections. Sexual Function, Gender, and Damage from Cancer TreatmentThe most common sexual problems after cancer treatment include loss of desire for sex in men or women, erectile dysfunction (ED) in men, and pain with sexual act...

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Section: Sexual Function Gender and Damage From Cancer Treatmentmentioning

confidence: 99%

Sexuality and Fertility after Cancer

Schover¹

2005

Hematology

164

124

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“…Health-related quality of life (HRQOL) outcomes may vary based on sex, as differences for rectal cancer survivors have previously been noted. 3 An intestinal stoma, or ostomy, is the surgical exteriorization of the bowel to the anterior abdominal wall. This may include the small (ileostomy) or large (colostomy) bowel.…”

Section: Introductionmentioning

confidence: 99%

Health-Related Quality of Life Among Long-Term Rectal Cancer Survivors With an Ostomy: Manifestations by Sex

Krouse

Herrinton²,

Grant³

et al. 2009

JCO

196

171

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A B S T R A C T PurposeIntestinal stomas can pose significant challenges for long-term (Ն 5 years) rectal cancer (RC) survivors. Specifying common challenges and sociodemographic or clinical differences will further the development of tailored interventions to improve health-related quality of life (HRQOL). Patients and MethodsThis was a matched cross-sectional study of long-term RC survivors conducted in three Kaiser Permanente regions. The mailed questionnaire included the modified City of Hope Quality of Life-Ostomy (mCOH-QOLOstomy) and Medical Outcomes Study 36-Item Short-Form Health Survey, version 2 (SF-36v2). Groups surveyed were permanent ostomates (cases) and those who did not require an ostomy (controls). RC survivors were matched on sex, age, and time since diagnosis. Comparisons between groups used regression analysis with adjustment for age, comorbidity score, history of radiation therapy, income, and work status. Results Response rate was 54% (491 of 909). Cases and controls had similar demographic characteristics.On the basis of the mCOH-QOL-Ostomy, both male and female cases had significantly worse social well-being compared with controls, while only female cases reported significantly worse overall HRQOL and psychological well-being. For younger females (Ͻ age 75 years), ostomy had a greater impact on physical well-being compared with older females. Based on the SF-36v2, statistically significant and meaningful differences between female cases and controls were observed for seven of the eight scales and on the physical and mental component summary scores. ConclusionMen and women report a different profile of challenges, suggesting the need for targeted or sex-specific interventions to improve HRQOL in this population. This may include focus on physical HRQOL for female ostomy survivors younger than age 75.

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“…It was reported 54.5 in a study by Zając et al [18] among patients with stoma due to rectal cancer. Studies showed that the score of QOL is getting better over time [19] . It has been shown that the QOL among disease-free survivors of rectal cancer after two years HRQOL: health-related quality of life; PF: physical functioning; RF: role functioning; CF: cognitive functioning; EF: emotional functioning; SF: social functioning; CT: chemotherapy; RT: radiotherapy; CRT: chemo-radiotherapy was higher than that in the general population [20] .…”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life and its correlates among rectal cancer survivors, Northwest of Iran

Aminisani¹,

Fatemi²,

Sarbakhsh³

et al. 2017

JCMT

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Aim:The objective of this study was to examine the health-related quality of life (HRQOL), and its correlates among rectal cancer survivors. Methods: This cross-sectional study was conducted in the northwest of Iran. Rectal cancer survivors were selected from teaching hospitals. HRQOL was estimated using the European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire C30. Information about sociodemographic, lifestyle and clinical features of disease was obtained by trained interviewers. Results: A total of 96 patients were included in this study with mean age of 57.31 ± 14.15 years, 54% were male and 59% over 55 years of age. Women performed poorer than men in many dimensions of HRQOL (P < 0.05). Total score of symptoms was higher in those who had a higher stage of the disease. Participants with insufficient physical activity had a lower score in physical and role dimensions and a higher score of pain and fatigue (P < 0.05). In multiple regression models, treatment, stage of disease, and physical activity were important predictive factors of HRQOL. Conclusion: Some clinico-epidemiological factors were associated with a reduced score of HRQOL and its dimensions in this study. Overall, better performance in the presence of a modifiable factor; physical activity, is an opportunity for interventional strategies to improve the HRQOL. Key words:Health, quality of life, rectal cancer, treatment, socioeconomic status ABSTRACTArticle history:

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Ten-Year Historic Cohort of Quality of Life and Sexuality in Patients With Rectal Cancer

Cited by 146 publications

References 40 publications

Sexuality and Fertility after Cancer

Sexuality and Fertility after Cancer

Health-Related Quality of Life Among Long-Term Rectal Cancer Survivors With an Ostomy: Manifestations by Sex

Health-related quality of life and its correlates among rectal cancer survivors, Northwest of Iran

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