Ten-year follow-up in patients with combined heart and kidney transplantation

Trachiotis, Gregory D.; Vega, J. David; Johnston, Thomas; Berg, Alexandria M.; Whelchel, John D.; Smith, Andrew L.; Lutz, Jerre F.; Kanter, Kirk R.

doi:10.1016/j.jtcvs.2003.07.009

Cited by 40 publications

(23 citation statements)

References 18 publications

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“…Although one of the first multi-institutional studies [3] of 82 HKT reported a survival rate 2-year lower than that of isolated heart transplant recipients, according to the UNOS database, this difference was not statistically significant; several more recent studies from single centres with a low number of cases have yielded encouraging results, both in terms of long-term graft function and patient survival [4][5][6][7]. Moreover, in a recent analysis Russo et al [8], referring also to the UNOS database, found that low risk patients with an estimated filtration rate of less than 33 mL/min gained a survival benefit from HKT over heart transplantation alone.…”

Section: Discussionmentioning

confidence: 95%

Combined Heart-kidney Transplantation: A Single Center Experience

Bacchi¹,

Potena²,

Mosconi³

et al. 2011

OJOTS

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Introduction: We report our experience with seven cases of combined heart-kidney transplantation (HKT). Patients and methods: Between January 2003 and December 2009, seven subjects underwent combined HKT, receiving both organs from a single donor. Their age ranged from 30 years to 59 years, six were male. Five patients were dialysis dependent before transplantation and two were in chronic renal failure (serum creatinine levels > 2.6 mg/dL). The heart was transplanted first in all cases. Results: Heart function rapidly re-covered in five of the patients, while two needed temporary inotropic and mechanical support. Diuresis started immediately in four patients. At discharge, all patients had well-functioning grafts (left ventricular ejection fraction 60% ± 6%; serum creatinine 1.4 ± 0.3 mg/dL). After an average follow-up period of 45 ± 24 months no deaths have occurred. Heart allografts are functioning normally in six patients and none of the patients currently require dialysis treatment. The main adverse event noted during follow-up was hypertension in five patients. Four patients were cardiac allograft rejection free and five patients were kidney rejection free. Conclusion: Our results are in line with the data which has been previously reported in the literature and suggest that HKT is a viable therapeutic choice in the treatment of advanced cardiac and renal failure in carefully selected patients.

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Section: Discussionmentioning

confidence: 95%

Combined Heart-kidney Transplantation: A Single Center Experience

Bacchi¹,

Potena²,

Mosconi³

et al. 2011

OJOTS

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“…Compared with isolated heart transplantation, simultaneous heart and kidney transplantation does not adversely affect short-term and long-term survival and results in a lower incidence of treated cardiac allograft rejection [2][3][4][5][6][7][8][9][10][11][12][13]. Recipients of simultaneous heart and kidney transplantations from a single donor have less acute rejection of the heart and the kidney allograft compared with isolated heart or kidney transplant recipients.…”

Section: Discussionmentioning

confidence: 99%

“…Recipients of simultaneous heart and kidney transplantations from a single donor have less acute rejection of the heart and the kidney allograft compared with isolated heart or kidney transplant recipients. Simultaneous rejection of both organs is very uncommon [2][3][4][5][6][7][8][9][10][11][12][13]16]. Cardiac allograft vasculopathy is also decreased significantly when cardiac transplantation is combined with a kidney allograft [17].…”

Section: Discussionmentioning

confidence: 99%

Simultaneous heart and kidney transplantation from a single donor

Hsu

Tsai

Lee

et al. 2008

European Journal of Cardio-Thoracic Surgery

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“…However, patients with severe renal dysfunction are transplanted. In select patients with co-existing end-stage heart and renal failure, simultaneous heart and kidney transplantation proved to have satisfactory results [3][4][5][6][7][8][9][10][11][12][13]. Simultaneous heart and kidney transplantation become an accepted therapeutic option for patients with end-stage heart failure associated with severe renal dysfunction.…”

Section: Introductionmentioning

confidence: 99%