Ten year experience with the negatively charged glutaraldehyde-tanned vascular graft in peripheral vascular surgery

Sawyer, Philip N.; Fitzgerald, John F.; Kaplitt, Martin J.; Sanders, Richard J.; Williams, G. M.; Leather, Robert P.; Karmody, Allstair; Hallin, Roger W.; Taylor, Robert J.; Fries, Charles C.

doi:10.1016/0002-9610(87)90272-8

Cited by 25 publications

(15 citation statements)

References 8 publications

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“…Considerable efforts have been made to functionalize synthetic surfaces [4, 5]. Natural biomaterial scaffolds, including well-studied grafts of decellularized blood vessels [6-8], have had limited success. The decellularized bovine [6] and human [7] blood vessels had promising 5 year patency rates, yet aneurysm formation due to in vivo degradation limited their widespread use [7, 8].…”

Section: Introductionmentioning

confidence: 99%

“…Natural biomaterial scaffolds, including well-studied grafts of decellularized blood vessels [6-8], have had limited success. The decellularized bovine [6] and human [7] blood vessels had promising 5 year patency rates, yet aneurysm formation due to in vivo degradation limited their widespread use [7, 8]. Decellularized arteries, from allogenic and xenogenic sources are attractive scaffolds for tissue-engineered vascular grafts due to their mechanical and biological properties [9], yet these natural scaffolds are limited by the lack of precise manufacturing control of the physical and mechanical properties, as well as problems with inflammation and calcification [18].…”

Section: Introductionmentioning

confidence: 99%

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Mechanical property characterization of electrospun recombinant human tropoelastin for vascular graft biomaterials

et al. 2012

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The development of vascular grafts has focused on finding a biomaterial that is non-thrombogenic, minimizes intimal hyperplasia, matches the mechanical properties of native vessels and allows for regeneration of arterial tissue. In this study, the structural and mechanical properties and the vascular cell compatibility of electrospun recombinant human tropoelastin (rTE) were evaluated as a potential vascular graft support matrix. Disuccinimidyl suberate (DSS) was used to cross-link electrospun rTE fibers to produce a polymeric recombinant tropoelastin (prTE) matrix that is stable in aqueous environments. Tubular 1 cm diameter prTE samples were constructed for uniaxial tensile testing and 4 mm small-diameter prTE tubular scaffolds were produced for burst pressure and cell compatibility evaluations from 15 wt% rTE solutions. Uniaxial tensile tests demonstrated an average ultimate tensile strength (UTS) of 0.36±0.05 MPa and elastic moduli of 0.15±0.04 MPa and 0.91±0.16 MPa, which were comparable to extracted native elastin. Burst pressures of 485 ± 25 mmHg were obtained from 4 mm ID scaffolds with 453 ± 74 μm average wall thickness. prTE supported endothelial cell growth with typical endothelial cell cobblestone morphology after 48 hours in culture. Cross-linked electrospun recombinant human tropoelastin has promising properties for utilization as a vascular graft biomaterial with customizable dimensions, a compliant matrix, and vascular cell compatibility.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mechanical property characterization of electrospun recombinant human tropoelastin for vascular graft biomaterials

et al. 2012

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“…However, the incidences of aneurysm and dilation are reportedly 36% and 21%, respectively, after grafting a glutaraldehyde-treated human umbilical cord vein graft [1]. The incidence of aneurysm was assumed to be 100% in human patients receiving peripheral vascular transplantation of such a biological graft [11]. It is necessary to carry out a more prolonged durability examination in the future.…”

Section: Discussionmentioning

confidence: 99%

A Long Term Comparison between Denacol EX-313-Treated Bovine Jugular Vein Graft and Ultrafine Polyester Fiber Graft for Reconstruction of Right Ventricular Outflow Tract in Dogs.

Matsui¹,

Sugiyama

Shibazaki

et al. 2003

The Journal of Veterinary Medical Science

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ABSTRACT. A Denacol EX-313 (Denacol)-treated bovine venous graft and an ultrafine polyester fiber (UFPF) graft were transplanted as patch graft into the right ventricular outflow tract under extracorporeal circulation in six dogs each experimentally. Hemodynamics in right heart and histological findings around the graft were compared between both groups over a period of one year after grafting. Pressure measurements and angiocardiography were performed through a cardiac catheter. Right ventricular pressure, pulmonary artery pessure, and right ventricle to pulmonary artery gradient were within normal limits in both groups at 1, 2, 3, 4, 6, and 12 months or more after grafting. No difference were seen between the values for the Denacol and the UFPF group. Histologically, the medial surface at the site of grafting was covered with vascular endothelial cells at one month after grafting in both groups. The density of the vascular endothelial cells increased with time after grafting, showing no clear difference between the two groups. Subendothelial layers comprised of collagen fibers, elastic fibers, and inflammatory cells decreased with time in both groups, but there was less cell infiltration in the Denacol group than in the UFPF group at all time points after grafting. In addition, the central cut thickness value of the graft tended to be thinner in the Denacol group than in the UFPF group at all observation time points after grafting. In the Denacol group, very slight metaplasia of cartilage was noted in a portion of the graft margin at six months or more after grafting, but no other abnormalities were observed. These results suggest that the Denacol-treated bovine venous graft has better grafting characteristics than the UFPF graft with easier intra-operative handlings and less tissue reactions after grafting. KEY WORDS: canine, Denacol EX-313, patch graft, pulmonic stenosis, ultrafine polyester fiber.

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“…The authors used bovine carotid artery treated with proteolytic enzymeficin -with the following preservation in formaldehyde. Further variations of the artery treatment methods consisted in the substitution of a cross-linking agent for a bifunctional one -dialdehyde starch or glutaraldehyde, the treatment process being made more complex [11][12][13]. Bioprostheses Solcograft and Solcograft-Р based on the ideas by Rosenberg were tested in patients [8,11] including multicenter studies with the number of patients over 100 [12,13].…”

Section: The Evolution Of Bioprostheses Of Infrainguinal Arteriesmentioning

confidence: 99%

Biological Analogs of Infrainguinal Arteries: Evolution and Development Prospects (Review)

Zhuravleva¹,

Zhuravleva²,

Zhulkov³

et al. 2017

Sovrem Tehnol Med

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Currently, the gold standard of plastic material for infrainguinal artery replacement is still autovein, however, not infrequently the necessity for prostheses arises.The review presents the characteristics of xeno-and allogenic prostheses for lower limb arteries, which have been used in vascular surgery worldwide since 1960-ies till the present.There have been analyzed the clinical results with the bioprostheses, their advantages and disadvantages being discussed. We have shown that the approach based on chemically cross-linked human and animal tissues used for bioprostheses is limited in its further development.We have studied the evolution of tissue engineering vascular grafts (TEVG), and carried out a critical review of current state of the issue, and presented further paths of its development.

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Ten year experience with the negatively charged glutaraldehyde-tanned vascular graft in peripheral vascular surgery

Cited by 25 publications

References 8 publications

Mechanical property characterization of electrospun recombinant human tropoelastin for vascular graft biomaterials

Mechanical property characterization of electrospun recombinant human tropoelastin for vascular graft biomaterials

A Long Term Comparison between Denacol EX-313-Treated Bovine Jugular Vein Graft and Ultrafine Polyester Fiber Graft for Reconstruction of Right Ventricular Outflow Tract in Dogs.

Biological Analogs of Infrainguinal Arteries: Evolution and Development Prospects (Review)

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